33 results about "Vitamin products" patented technology

The invention provides a feed additive for improving the quality of the fur of a furry animal. The additive is obtained by mixing a semi-finished vitamin product, a semi-finished trace element product, dihydropyridine, methionine, cystine and corn gluten meal according to a weight ratio of 1:1:0.3-1:0.2-0.9:0.1-0.6:2, wherein the semi-finished vitamin product is prepared by uniformly mixing the following components: 5-22 parts of vitamin A, 3-8 parts of vitamin D, 10-25 parts of vitamin E, 3-8 parts of vitamin B1, 8-15 parts of biotin, 1-3 parts of vitamin B6, and 120-160 parts of the corn gluten meal, and the semi-finished trace element product is prepared by uniformly mixing the following components: 10-20 parts of methionine chelated zinc, 2-5 parts of methionine chelated copper, and 70-90 parts of zeolite powder. The additive of the invention allows the quality of the fur of the furry animals (martens, foxes and raccoon dogs) to be substantially improved, the hair density to be increased, the hair length to be improved, the hide toughness to be increased and the culture benefit to be improved.

The invention belongs to the field of healthcare products and particularly relates to compound vitamin tablets and a preparation method thereof. Each compound vitamin tablet provided by the invention comprises a tablet core and a film coating layer, wherein the tablet core is mainly prepared from vitamin A acetate, sodium ascorbate, DL-alpha-tocopheryl acetate, nicotinamide, calcium pantothenate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, D-biotin, zinc oxide, sodium selenite, pre-gelatinized starch, maltodextrin, microcrystalline cellulose and silicon dioxide; and the film coating layer is mainly prepared from hydroxypropyl methyl cellulose, polyethylene glycol 4000, polyvinylpyrrolidone, titanium dioxide, castor oil and water. The compound vitamin tablets provided by the invention have the advantages of high safety and abundant nutrition and can provide the vitamins and minerals necessary for pregnant women so as to enhance immunity; meanwhile, the compound vitamin tablets can effectively reduce the abortion rate of pregnant women and oaf incidence; and therefore, the compound vitamin tablets are a perfect compound vitamin product for pregnant women.

The invention relates to a simple and convenient preparation method of a key intermediate (2-methyl-4-amino-5-amino methyl pyrimidine) for the vitamin B1. According to the method, lewis acid is used for catalyzing addition condensation reaction of acetamidine and 3-formyl amino ethyl cyanide and then catalyzing reaction of the condensation product and triethyl orthoformate to introduce a formyl chiral auxiliary, an imdo group and the formyl chiral auxiliary are subjected to ring formation to form 2- methyl-4-formyl amino-5- amino methyl pyrimidine, and finally basic hydrolysis is performed, so that 2-methyl-4-amino-5-amino methyl pyrimidine is obtained. The reaction procedures are carried out sequentially by adopting the one-pot method, the products in each step require no separation and purification, and the operation is simple and convenient. According to the method, highly toxic o-chloroaniline and other phenylamine compounds are not used, so that residue of o-chloroaniline compounds in the vitamin B1 product can be completely avoided. Meanwhile, the production wastewater is less and the yield is high.

An ELISA (enzyme linked immunosorbent assay) kit of folic acid belongs to the technical field of enzyme linked immunosorbent assay. The reagent components in the kit comprise: an enzyme label plate coated with a folic acid coating antigen (the antigen is prepared by coupling folic acid and ovalbumin); a folic acid polyclonal antibody; a goat anti-rabbit antibody marked by enzyme-labelled bi-antibody which is horseradish peroxidase; a folic acid standard solution; a concentrated phosphate buffer; a concentrated cleaning solution; a substrate colour developing solution A; a substrate colour developing solution B and a stop solution. The ELISA kit provided by the invention performs ELISA by using a polyclonal antibody, wherein IC50=15.5ng / ml. The lowest detecting limit in milk products is 11.9ng / ml; the coefficients of variation between batches and in batches are 11.8%; and the recovery is 89.1-110.3%. The ELISA kit provided by the invention has the characteristics of simple structure, fast operations, accurate detection result and high sensitivity; and the kit can be used for fast detecting folic acids contained in foods, feeds and vitamin products.

The invention relates to a process for removing trace quantity of multicomponent aromatic hydrocarbons from natural vitamin E by using natural vitamin E as the solute, inert organic solvent as the solvent, charging 5-6% of removing agent at the presence of nitrogen protection, controlling the temperature to be 60 deg. C, mixing through external circulation, filtering, condensing, then refining through molecular distillation.

The invention discloses a process for coating a multi-vitamin for a cow rumen. The process comprises the following specific steps of (1) weighing raw materials and mixing to obtain a first mixed raw material, adding carboxymethyl cellulose to the first mixed raw material for granulation to obtain a core material; and (2) adding a coating material to the core material and sampling the coating material through a peristaltic pump at a speed of 8-11 ml / min under the conditions that the atomization pressure is 1.2-1.8MPa, the air-induced frequency is 50HZ, the compressed air temperature is 52-60 DEG C, the air inlet temperature is 36-46 DEG C and the air outlet temperature is 22-25 DEG C to obtain a finished product. A compound polymer material sensitive to a pH value is a coating wall material, a bottom-spray fluidized bed coating process of coating after granulation is adopted and relatively ideal physical coating protection can be carried out on the multi-vitamin of a ruminant; and the ratio of the coating material and the core material is 6-8%, so that the rumen protection rate of a prepared multi-vitamin-coated product is greater than 70%, the release rate of a true stomach (abomasums) is greater than 60% and the economical benefit of a feeder can be improved.

The invention discloses a feed additive for improving the quality of poultry eggs. The additive is a mixture of carrot nutrition powder, semi-finished vitamin product, a yeast culture and amino acid. Every kilograms of additive contains 20 to 30 parts by weight of carrot nutrition powder, 10 to 20 parts by weight of semi-finished vitamin product, 15 to 25 parts by weight of composite amino acid and 30 to 40 parts by weight of yeast culture. A production method for the feed additive comprises the following steps of preparing the carrot nutrition powder, the semi-finished vitamin product and the composite amino acid, and uniformly and proportionally mixing the carrot nutrition powder, the semi-finished vitamin product, the composite amino acid and the yeast culture to obtain a final product. The product is applied to the egg producing period of a laying chicken or a laying duck. The production method is simple, the equipment investment cost is low. If the laying chicken or the laying duck is fed according to a method provided by the invention, the stabilization of the intestinal micro-ecological environment of the laying egg can be promoted, the absorption, utilization and deposition of nutrient substances can be promoted, the egg productivity and body resistance of the laying chicken and the laying duck can be improved, and the quality of the eggs can be improved.

The invention discloses a preparation technology for a natural vitamin E. The preparation technology comprises esterification, water washing, cold crystallization, solid-liquid separation, molecular distillation, column chromatography adsorption, and secondary molecular distillation and the like; according to the preparation technology for the natural vitamin E, the molecular distillation technology and the column chromatography technology are combined, so that the higher-purity natural vitamin E is prepared; the adsorption resin is a filling agent and used for purifying the natural vitamin E through column chromatography, the total content of the natural Vitamin E product prepared is 90% above, and the total yield is 80% above. Because the molecular distillation is performed for two times, by-products can be removed to the greatest extent, the natural vitamin E with good quality, more transparent color, qualified optical rotation, and high quality can be prepared; the process route has the characteristics that the steps are less, the yield is high, and the operation condition is mild; meanwhile, the process can be reduced greatly, the high-purity natural vitamin E can be obtained, the yield is higher, and the cost is reduced.

The invention relates to a method for separating and purifying vitamin K2 in fermentation liquor by using palm oil extract, which comprises the following steps: separating the fermentation liquor to obtain wet thalli, conducting freeze-drying to obtain dry thalli, mixing the dry thalli with palm oil extract for 2-4h, and conducting centrifuging to take supernate; packing pretreated macroporous resin into a column, putting the supernate into the separation column filled with the macroporous resin, removing miscellaneous oil substances by using a first eluent, and eluting the vitamin K2 from the macroporous resin by using a first desorption agent to obtain an eluate; concentrating the obtained eluate to obtain a concentrated solution; putting the concentrated solution into a separation column containing reverse phase silica gel, removing impurities by using a second eluent, conducting eluting by using a second desorption agent to obtain a high-purity vitamin K2 product, and conducting freezing and crystallizing to obtain vitamin K2 crystals. The palm oil extract used in the invention exists in the nature, is relatively simple to obtain and does not generate organic waste liquid, so that the pollution to the environment is greatly reduced.

The invention provides a stabilization coating technology for a composite biological vitamin, particularly a stabilization coating technique for enteric feed biological vitamins. The technique includes preparing a fermentation liquid, performing separation and concentration to obtain fermented milk, and performing biological multi-dimensional granulation, drying, coating and other steps to obtaina composite biological vitamin product. The technique effectively combines lactic acid bacteria, yeast and vitamins into one product, and greatly improves stress resistance of probiotics and vitamins,greatly improves storage stability of probiotics and vitamins, and achieves better tolerance against damage caused by a plurality of harmful factors such as trace metal ions, choline chloride, antibiotics, etc. in feed. A situation that tolerance to high temperature of feed granulation processes is absent is improved, and more importantly, the biological multi-dimensional coated product which cansafely pass through gastric juice and is rapidly disintegrated in the intestinal tract of the animal is prepared.

The invention provides a novel biological agent product special for ruminants and belongs to the technical field of feed additives. The novel biological agent product is prepared from, by weight, 60-70 parts of a yeast product and 30-40 parts of a vitamin product; the yeast product is obtained by granulating an active yeast additive carrier and an adhesive, wherein the content of active yeast in the yeast product is 7*108-15*108 cfu / g; the vitamin product is obtained by granulating a multi-vitamin additive carrier and an adhesive. The novel biological agent product special for ruminants can remarkably improve the survival and reproduction ability of the active yeast in the rumen environment, is remarkable in heat stress resisting effect, remarkably improves production performance of ruminants and has the advantages of being safe, ecological, free of residues and drug resistance and the like.

The invention belongs to a nursing device and provides a suction type nursing rod combination and a suction type nursing set, so as to solve the problems that in the case of poor air quality or life and work in a special environment at present, adverse effects are likely to be caused to body health, and harm is caused to the body health when the user smokes the electronic cigarette product for a long time. The nursing rod combination comprises a carrier rod and a hollow outer rod body, wherein the carrier rod is placed in the outer rod body; one end of the outer rod body is provided with a suction nozzle and the other end is provided with an air hole; the suction nozzle and the air hole are communicated with the hollow part of the outer rod body; the carrier rod carries a suction type nursing material; the suction type nursing material is one or a combination of more than one of a traditional Chinese medicine extract, a plant extracting solution, a vitamin product and essential oil. The nursing set further comprises a packaging box or a packaging bag used for containing the suction type nursing rod combination. The number of the outer rod bodies is one or more, the number of the carrier rods is one or more, and the number of the containers is zero, one or more. When the number of the containers is more than one, the types of the suction type nursing materials are different.

The invention discloses a synthesis process of vitamin B5. The process comprises the following steps: adding glyoxylic acid and triethylamine into a reaction kettle; stirring until an obtained solution is yellow, transparent and clear; slowly dropwise adding isobutyraldehyde; extracting by using 1, 2-dichloroethane; removing a water layer for wastewater treatment; distilling to remove 1, 2-dichloroethane, continuously distilling to obtain a DL-pantolactone finished product, then splitting to obtain 99% d-pantolactone, mixing methanol, calcium oxide and alanine for calcium salt reaction, addingthe d-pantolactone for synthesis after the reaction is finished, and then crystallizing, drying and packaging to finally obtain a vitamin B5 product. The method is reasonable in synthesis process, low in cost and small in pollution, generated wastewater is neutralized through liquid caustic soda, an organic phase is neutralized through 10% sodium carbonate, direct emission of wastewater and wastegas is greatly reduced, and environment protection is facilitated.

The invention relates to the technical field of vitamin K2 preparation, in particular to a method for extracting vitamin K2 from fermentation liquor. The method comprises the following steps: (1) inoculating flavobacterium into a culture medium for fermentation, adding a settling accelerator into the fermentation liquor after fermentation, and separating thalli for later use after the thalli in the fermentation liquor are settled; (2) freeze-drying the thalli, crushing the thalli into powder, mixing the powder with acetone, performing extraction, and taking an extract liquor for later use after the extraction is completed. (3) adding clear water into the extract liquor, and separating out precipitate after the precipitate is completely separated out so as to obtain a crude product of a vitamin K2 product. and (4) mixing the vitamin K2 crude product with acetone again for extraction, then adding clear water, and separating out a precipitate after the precipitate is completely separated out so as to obtain a vitamin K2 product. The method provided by the invention not only can effectively extract the vitamin K2 in flavobacterium, but also has the characteristics of convenience in extraction and suitability for industrial application.

The invention discloses a method for removing mineral oil in natural vitamin E, which comprises the following steps: (1) sample loading: take a separating agent, add eluent a, fill it into a chromatographic column, wash it with eluent a Decompress the chromatography column, dissolve and load the sample according to raw material: eluent a (m / v) = 2: 1; (2) Elution: elute with the eluent a described earlier after loading the sample, and then Elute with eluent b; (3) Collection: collect the eluate in sections and concentrate to obtain natural vitamin E products; (4) Regeneration: wash and regenerate the chromatographic column with eluent c; the raw material is natural Vitamin E; the eluent a is a weak polar solvent; the eluent b is a mixed weak polar solvent composed of the eluent a and the eluent c; the eluent c It is a strong polar solvent. The invention well solves the problem of trace residue of mineral oil in natural vitamin E by utilizing the polarity difference between mineral oil and natural vitamin E.

The invention relates to a simple and convenient preparation method of a key intermediate (2-methyl-4-amino-5-amino methyl pyrimidine) for the vitamin B1. According to the method, lewis acid is used for catalyzing addition condensation reaction of acetamidine and 3-formyl amino ethyl cyanide and then catalyzing reaction of the condensation product and triethyl orthoformate to introduce a formyl chiral auxiliary, an imdo group and the formyl chiral auxiliary are subjected to ring formation to form 2- methyl-4-formyl amino-5- amino methyl pyrimidine, and finally basic hydrolysis is performed, so that 2-methyl-4-amino-5-amino methyl pyrimidine is obtained. The reaction procedures are carried out sequentially by adopting the one-pot method, the products in each step require no separation and purification, and the operation is simple and convenient. According to the method, highly toxic o-chloroaniline and other phenylamine compounds are not used, so that residue of o-chloroaniline compounds in the vitamin B1 product can be completely avoided. Meanwhile, the production wastewater is less and the yield is high.

The invention relates to a method for extracting natural vitamin E from by-product residual oil, which comprises the following steps: contacting the by-product residual oil dissolved in an organic solvent with strongly basic anion exchange resin HZ-202, eluting the resin, collecting the eluted fraction, and drying to obtain the natural vitamin E, wherein the byproduct residual oil contains vitamin E succinate and / or vitamin E acetate. By adopting the method disclosed by the invention, not only is the natural vitamin E efficiently recovered, but also the natural vitamin E product with relatively high purity can be obtained, and in addition, the specific rotation of the obtained natural vitamin E product is obviously improved.

The invention discloses a method for extracting vitamins from guavas. The method comprises the following steps of: (1) selecting the guavas, thoroughly cleaning the selected guavas, cutting the cleaned guavas in an extraction protective solvent, and removing seeds; (2) adding the flesh of the cut guavas and the extraction protective solvent in a vacuum pulping machine together, and pulping the guava flesh; (3) adding the pulp generated through pulping to a vacuum mixer to perform vacuum mixing; (4) filtering the materials obtained in the step (3) to obtain a filtrate, leaving the filtrate to stand for layering, and performing separation so as to obtain an organic phase; (5) adding water of which the pH is smaller than 7 to the organic phase obtained in the step (4), and performing vacuum mixing for 2 hours or more so as to obtain a solution; (6) leaving the solution to stand for layering, and performing separation so as to obtain an aqueous phase; and (7) performing vacuum concentration on the aqueous phase until the concentrated aqueous phase is dried, and performing freeze drying so as to obtain crude vitamin products. Through the adoption of the extraction method disclosed by the invention, the vitamins in the guavas can be extracted; the extraction method is simple, and is suitable for large-scale popularization and application; the content of the vitamins in extract is high.

The invention provides a composite vitamin health-care food composed of vitamin E, vitamin D, folic acid, vitamin B12 and health-care food acceptable auxiliary materials, aiming at the health risk ofperimenopausal women. The nutritional supplement accurately supplements vitamin E, vitamin D, folic acid and vitamin B12 so as to improve estrogen disorder, prevent osteoporosis and climacteric depression and protect the cardiovascular system. The nutritional supplement is not only a significant improvement and upgrade of existing compound vitamin products, but also an example for implementing accurate nutrition on physiological characteristics of perimenopausal women, and has process feasibility and good market prospects.

The invention discloses a high-stability vitamin A and a preparation method thereof. The method comprises the following steps: carrying out wittig reaction on a C15 phosphine salt mixture and pentacaraldehyde under the action of alkali liquor to prepare vitamin A acetate crude oil, and recrystallizing to obtain vitamin A crystals. By controlling the contents of the compound I and the compound II in the C15 phosphine salt mixture to be 0.1 wt%-1wt%, the content of VA dimer in the vitamin A acetate crude oil is less than 0.1%, and the chemical stability of a vitamin A product can be remarkably improved. The chromatic value of the obtained VA crystal solution is smaller than 60 HAzen, the average size of the VA crystal is 100-200 microns, and the problems that the VA crystal is yellow in color, easy to agglomerate and large in particle size are effectively solved.

The invention relates to a method for removing zearalenone from natural vitamin E and a pure vitamin E product obtained by the method. The method for removing zearalenone comprises the steps of pretreatment with iminodiacetic acid type chelating resin, column packing, adsorption, washing, separation and the like. The process of the method for removing zearalenone in the present invention is simple, does not introduce other substances, does not require other separation steps, and does not cause secondary pollution to vitamin E products; compared with adsorbents such as diatomite montmorillonite, the adsorption The efficiency is about 80-90% high, and the material loss is small.

The invention relates to a method for removing natural vitamin E containing glycidyl ester, 3-chloropropanediol and esters thereof and a high-purity vitamin E product obtained by the method. The removal method comprises the steps of activated carbon acid treatment, activated carbon acylating chlorination, activated carbon amination, adsorption, separation and the like. The technical process is simple and easy to implement, no secondary pollution is caused to the natural vitamin E product, and compared with the used natural vitamin E raw material, the glycidyl ester content and the total content of 3-chloropropanediol and 3-chloropropanediol ester of the high-purity vitamin E product obtained through the method are reduced by 85% or above and 88% or above respectively.

The invention relates to a synthetic method of 2-methyl-4-amino-5-formyl aminomethylpyrimidine. The method comprises the following steps: a benzene solvent and a solid acid catalyst are added to a reaction flask and stirred, alpha-sodio formyl-beta-formyl aminopropionitrile is added, heating is performed, an acetamidine hydrochloride solution dissolved in an alcohol solvent is added dropwise, a thermal reaction and filtering are performed, the solid acid catalyst is recovered and treated for recycling, and a filtrate is a 2-methyl-4-amino-5-formyl aminomethylpyrimidine solution. O-chloroaniline as a raw material used in the traditional synthetic process is not used, 2-methyl-4-amino-5-formyl aminomethylpyrimidine is directly synthesized from alpha-sodio formyl-beta-formyl aminopropionitrile and acetamidine hydrochloride under the action of the solid acid catalyst, intermediate processes are omitted, the method is an environment-friendly process because the solid acid catalyst is recyclable, and trace cancerogen residues in a vitamin B1 product are avoided; synthesis yield is high, and the requirement for current green development is met.

The invention relates to a method for removing zearalenone from natural vitamin E and a pure vitamin E product obtained by the method. The method for removing zearalenone comprises the steps of imino diacetic acid type chelate resin pretreatment, column packing, adsorption, leaching, separation and the like. The method for removing zearalenone is simple in process, does not introduce other substances, does not need other separation steps, and does not cause secondary pollution to the vitamin E product; and compared with adsorbents such as diatomite and montmorillonite, the adsorption efficiency of the method is about 80-90% higher, and the material loss is small.

The invention discloses a method for extracting natural vitamin C from capsicum granules. The method comprises the following steps: (1) degreasing: placing a proper amount of capsicum granules in a reaction tank, adding a degreasing solvent, carrying out stirring at a normal temperature, and carrying out filtering separation, so as to obtain degreased residues; (2) extracting: adding a vitamin C extracting solution into the degreased residues, carrying out vacuum stirring at a low temperature, and carrying out filtering separation, so as to collect filter liquor; (3) capsaicin removing: addingvegetable oil in the filter liquor, carrying out vacuum stirring at a normal temperature, and carrying out water-oil separating, so as to collect a vitamin C aqueous solution; and (4) drying: subjecting the vitamin C aqueous solution to vacuum depressurized concentration, and then, carrying out vacuum freeze drying, thereby obtaining the natural vitamin C. According to the method disclosed by theinvention, due to degreasing pretreatment, interference to detection on the vitamin C caused by lipids is avoided, and meanwhile, the rate of extraction can be increased; due to vacuum low-temperature extraction, the loss of the vitamin C is lowered to the maximum; due to capsaicin removing treatment, the purity of the vitamin C product is improved; and the method is simple in operation, easy toimplement and low in cost.

The invention discloses a method and a system for low-residual multi-stage stripping of a vitamin E by-product fatty acid solvent, and the method is as follows: distilling a deodorized distillate fromwhich sterol is removed to respectively obtain a distillate and a residual liquid; performing multi-stage stripping on the distillate, and evaporating a solvent to obtain a vitamin E product. The method has the advantages of extremely low residual capacity, low labor intensity, low environmental pollution, easy control of reaction, and high purity and high recovery rate of the vitamin E.