The invention provides a safe synthesis method of 1,3,5-triamino-2,4,6-trinitrobenzene, wherein the safe synthesis method comprises the steps: based on the isomerism characteristics of 1,3,5-cyclohexyltriketone
imine and 1,3,5-triaminobenzene, taking 1,3,5-cyclohexyltriketone as a reaction
raw material, and preparing N,N',N''-triacetyl-1,3,5-triaminobenzene through a trioximation reaction, an N-O
bond cleavage-isomerism reaction and an N-
acylation reaction; and taking N,N',N''-triacetyl-1,3,5-triaminobenzene as a
raw material, and preparing
TATB through a multi-stage one-pot tri-
nitration reaction. The method has the significant characteristic of the multi-stage one-pot tri-
nitration reaction, so that the
amination step of an explosive multi-nitro-compound is avoided so as to substantially improve the safety, the used reactants or the used catalyst is the common product in the
chemical industry, the use of a non-degradable
organic solvent is avoided, the green and safe synthesis is achieved; and meanwhile, on the basis of the characteristics of a one-pot method, the operation process is simplified, operations such as separation, purification and collection of an
intermediate product are avoided, and large-scale preparation of 1,3,5-triamino-2,4,6-trinitrobenzene is facilitated.