48 results about "Taste Bud Cells" patented technology

The present invention relates to high-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers. Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans. The inventive electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function. Compounds that enhance or block TRPML3 channel activity should thereby modulate salty taste. In addition, these compounds may be used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels. This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The TRPML3 gene also modulates one or more of sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion. The inventors have identified TRPML3 as encoding a salty taste receptor in primates and humans (and likely other mammals) based on gene expression assays which have determined that TRPML3 is expressed specifically in taste bud cells and not in lingual epithelial cells, similar assays that have determined that TRPML3 is specifically expressed or enriched in the top half of taste bud cells in a subset of taste cells which do not express TRPM5 or PKD2L1, prior reports that document the expression of TRPML3 in other sensory organs such as the ear (therefore further substantiating the role of TRPML3 as a 'professional' sensory gene).

The invention discloses a formula and a preparation method of electronic cigarette tobacco tar. The formula comprises essence and a tobacco tar base, wherein the tobacco tar base comprises a solvent and a greasiness reducing combination agent, wherein the solvent comprises glycerol, propylene glycol and water, the greasiness reducing combination agent comprises nicotine, organic acid and tobacco polyphenol, the weight percentage of nicotine in the tobacco tar base is 2-5%, the molar ratio of organic acid to nicotine is (1-3):1, and the weight percentage of tobacco polyphenol in the electronic cigarette tobacco tar is 0.0001-1%. According to the electronic cigarette tobacco tar disclosed by the invention, the greasiness reducing combination agent is added into the solvent, and comprises tobacco polyphenol, so that the tobacco polyphenol and derivative products thereof entering the oral cavity of a consumer can generate a relatively strong effect with taste buds when the consumer smokes, the perception of the consumer on the sweet greasy feeling is reduced, and the sweet greasy feeling of the tobacco-flavored atomized electronic cigarette is improved.

A brush head device of a multifunctional oral care tool, especially a pair of transmission rods, which are respectively connected to a pair of brush heads. Rotate in opposite directions, and a recoil plate is set behind the pair of brush heads. The end of the transmission rod is lower than the end of the brush head. The top of the recoil plate is lower than the top of the brush head. It overcomes the problem of deep cleaning of the tongue coating and the problem that the traditional device is not only bulky and not easy to carry. It overcomes the problem that traditional toothbrushes and tongue brushes have single functions and cannot completely remove the dirt in the entire oral cavity. It overcomes the problems that traditional toothbrushes are easy to hide and breed bacteria, and are easy to cause damage to gums, teeth, taste buds, and tongue papilla.

The present invention relates to a multifunctional pet food and a preparation method thereof. The multifunctional pet food can provide eight nutrient substances required by brain development, improvesmental activity of dogs, and has effects of benefiting brain and helping memory. By supplementing elements with stress reaction resistance and oxidation resistance, the multifunctional pet food effectively reduces damages of stress reaction on pets, plays effects of calming nerves and relieving tension emotions, can promote rapid proliferation of taste bud cells of tongue mucosa, regulates appetite, inhibits certain harmful bacteria in intestinal tracts, improves secretion functions of a digestive system and activity of enzymes in histiocytes, and finally plays effects in regulating intestines and stomach to help digestion. In conclusion, under synergistic effects of the raw materials, the multifunctional pet food has multiple effects of delaying memory decline, enhancing learning ability, relieving and relaxing stress reaction resistance, refreshing breath, improving intestinal health, protecting joints, helping sports, promoting development of puppies, etc.

According to the lacosamide oral solution and the preparation method thereof, sodium carboxymethyl cellulose, povidone and polyethylene glycol are used as taste-masking combined matrixes, the viscosity of the oral solution is increased, the contact time of a medicine and a taste bud is shortened, the strong bitter taste of the lacosamide oral solution can be effectively masked under the condition that a sweetening agent is not added, and the taste of the lacosamide oral solution is improved. The attention of a patient on bitter taste is transferred through the cooling effect of menthol, the medication compliance of the patient is improved, the stability of an oral solution is improved, and the validity period of the medicine is prolonged. In the lacosamide oral solution provided by the invention, the variety of auxiliary materials is less, the preparation method is simple, and the lacosamide oral solution has a good taste masking effect and stability.

The invention discloses salty edible salt and a preparation method thereof. The salty edible salt comprises the following components: refined salt; fruit organic acid, wherein the mass of the fruit organic acid is 0.1%-5% of the mass of the refined salt, and the pH value of the fruit organic acid is 2-4; a yeast extract, wherein the mass of the yeast extract is 0.01%-0.1% of the mass of the refined salt; and an anti-caking agent. According to the invention, the salinity of the refined salt is improved directly through a pure natural, green and healthy formula, no potassium salt is introduced,and the perception of human taste buds on the salty taste is enhanced, so that people eat less salt without influencing the happiness of enjoying delicious foods, and the salt can be really reduced without reducing the salinity.

The invention provides a novel splice-variant of the ClC-4 protein, termed ClC-4A. ClC-4A is expressed in taste bud cells and is involved in sour taste perception. The invention provides ClC-4A polynucleotides and ClC-4A polypeptides, vectors, host cells and ClC-4A specific antibodies as well as designing high potency taste stimuli, determining taste preferences in animals, developing breed-specific foods, and modifying the taste of foods and medications.

The invention discloses an automatic medicine feeding device for infants, which comprises: a hollow tube, the first end of which is closed, and the first end of the hollow tube is provided with a liquid outlet; the second end of the hollow tube an opening; a piston that closes the second end of the hollow tube and moves along the hollow tube under external force; and a dissolvable shell that wraps around the first end of the hollow tube and The liquid outlet hole at the first end of the hollow tube is closed. The invention prevents the medicinal liquid from directly contacting the taste buds of infants and young children, avoiding the infants’ resistance to the medicine feeder, and because the soluble shell has a delicious taste, the infants will take the initiative to contain it in the mouth, and after the shell is partially melted , the medicine liquid automatically enters the infant's mouth under the action of pressure, and the taste of the medicine is covered by the taste of the soluble shell, making it easy for the infant to accept the medicine, so that the medicine can be taken happily and actively without conflicting psychology, and will not Waste of medicine.

The invention discloses a drinking utensil which is used for solving the problem that children resist to drinking bitter medicines when getting sick. When in use, two straws are placed in the oral cavity of a child, and the outlets of the two straws are at different positions in the oral cavity: one long straw cooperates with one short straw. The short straw outlet is located at a normal sucking position of the middle front portion of the tongue surface, and the long straw outlet crosses over the taste bud area where the tongue surface can taste and reaches the throat or a position below the throat. The inlet ends of the two straws are respectively connected to the two liquid containers. The long straw is connected to an extrudable container, and the container is used for containing a bitter medicine liquid; and the container connected to the short straw is used for containing a sweet drinking liquid. In the using process, children are induced to suck and swallow the sweet drinking liquid through the short straw by utilizing the sweet drinking liquid, meanwhile, the bitter medicine liquid in the medicine liquid container is sucked or squeezed into the medicine liquid container by parents at the swallowing moment, and the bitter medicine liquid is directly guided to the throat or the part below the throat after the long straw crosses over the taste bud area of the tongue surfaceand is swallowed into the stomach together with sweet drinking liquid swallowed to the throat. The taste of people mainly depends on taste bud cells distributed on the tongue surface of the tongue, and the bitter medicine liquid is not in contact with taste bud cells when passing through the oral cavity, so that children only taste the sweet taste of the drinking liquid and cannot taste the bitter taste of the medicine liquid in the swallowing process, the purpose of enabling the children to unconsciously and smoothly finish drinking the bitter medicine is achieved, and the problem faced by vast parents that the children resist to drinking the bitter medicine after illness is solved.

The invention discloses Chinese herbal medicine mouthwash and a preparation method thereof, and belongs to the technical field of mouthwash preparation. The Chinese herbal medicine mouthwash is prepared from raw materials, by weight, 1-5 parts of cortex cinnamomi extract, 5-10 parts of folium mori extract, 4-7 parts of flos caryophylli extract, 3-8 parts of herba pogostemonis extract, 1-5 parts of herba taraxaci extract and 10-20 parts of herba menthae extract. The Chinese herbal medicine mouthwash has a good halitosis removal effect, can effectively improve the flora environment in an oral cavity, does not color the surfaces of teeth and oral mucosa, does not cause the problem of taste bud and taste decline, and has no adverse effect on human health.

The invention provides 3D carved eye-protecting tremella jelly capable of sublimating vision and taste buds, relates to a preparation method, and belongs to the field of food, aiming at the defects that products in the existing market are not novel enough, not outstanding enough in function, single in market and the like. The jelly consists of the following raw materials in parts by weight: 10-25 parts of tremella, 25-40 parts of jelly powder, 5-10 parts of a thickening agent, a small amount of white granulated sugar and lemon juice, 5-15 parts of milk, and 10-25 parts of juice of blueberries, Chinese wolfberry fruits, kiwi fruits and the like. According to the jelly, the eyesight-improving food materials and the tremella liquid are added to replace jelly liquid, a 3D carving technology is adopted, and the jelly is an eye-protecting food with improved color and flavor and an active substance with the effects of effectively relieving visual fatigue, preventing and treating radiation damage and the like, so the effects of beautifying and protecting eyes are achieved, and the jelly has a wide market prospect.

The invention discloses a fixed acid stimulation recovery device for cerebral apoplexy, which comprises a fixed shell, a micro air pump, a Laval nozzle, an acid powder chamber, a scaling nozzle, a conduit, an air storage chamber and a probe; the micro air pump is installed on the side wall of the fixed shell on; the output end of the miniature air pump extends into the inside of the fixed shell; the input end of the Laval nozzle is connected to the output end of the micro air pump; the zoom nozzle is installed inside the fixed shell; the nozzle of the zoom nozzle is connected to the output end of the Laval nozzle Corresponding; the acid powder bin is installed on the upper end of the fixed shell, and acid powder is installed in the acid powder bin; the bottom of the acid powder bin is connected to the inside of the fixed shell; one end of the conduit is connected to the zoom nozzle, and the other end protrudes from the inside of the fixed shell; the gas storage chamber is connected to the conduit The end; the probe is connected to the air storage chamber; the invention uses the Laval nozzle and the zoom nozzle as the carrier, drives the acid powder to the patient's mouth through the airflow, activates the patient's taste buds, further promotes the secretion of saliva, and reconstructs the swallowing reflex.

The invention provides a taste-masking compound based on a porous carrier and a preparation method and application thereof. The taste-masking compound is composed of a readily soluble bitter drug, a porous carrier and a release modifier; the release of the drug from the taste-masking compound can be regulated. , significantly reducing the contact chance of bitter drugs with taste buds in the oral environment, so as to achieve the purpose of taste masking. The present invention provides the formulation composition and preparation method of the above-mentioned taste-masking compound. The taste-masking compound is suitable for the taste-masking of high-dose bitter drugs, and the drug release can be regulated as required, and can be further prepared into suitable dosage forms for children such as granules, dry suspensions, orally disintegrating tablets, dispersible tablets and chewable tablets, etc. It can improve the compliance of children's medication and meet the clinical medication needs of pediatric patients.