The invention relates to production equipment and a preparation method of high-content polyoxin raw
powder. The preparation method comprises the following steps: filtering acidified polyoxin
fermentation liquor through a plate frame, treating the plate frame filtrate through an
ultrafiltration membrane, adding
calcium chloride into the
ultrafiltration membrane to carry out
protein coagulation, carrying out decolorization membrane treatment, and carrying out concentration and
dialysis treatment in a
nanofiltration membrane, and finally, carrying out
activated carbon static adsorption treatmenton the concentrated solution, and carrying out
spray drying to generate high-content polyoxin raw
powder. According to the method, an
ultrafiltration membrane, a decolorization membrane and a
nanofiltration membrane are used for continuously separating the polyoxin filtrate, and finally,
activated carbon is used for refining separation so that the content of the produced polyoxin raw
powder reaches 34.0% or above, the appearance of the raw
medicine is white or off-white, and the breakthrough of the quality of the raw powder can generate beneficial factors on the
production quality stability ofdownstream preparations; meanwhile, the technical
bottleneck of development of high-content dosage forms and compound dosage forms of
pesticide preparations in the next step is solved.