The invention relates to a disinfection device, particularly relates to a scalpel disinfection device for medical treatment, and aims at solving the technical problem of providing a scalpel disinfection device with complete disinfection for medical treatment. To solve the technical problem, the device comprises a left support, a basal plate, a wastewater tank, a right support, a water outlet pipe, a first slide block, a filter screen, a first slide rail, a washing groove, a gear, a second motor, a second slide block and the like, wherein a first motor and the first slide block are arranged on the right side of the left support; the first motor is arranged above the first slide rail, and the first slide block is arranged on the first slide rail; the washing groove is formed in the top end of the first slide block, and a filter screen is arranged in the washing groove; and the water outlet pipe is arranged on the rear side of the bottom of the washing groove. The scalpel disinfection device has the effects of complete disinfection, high disinfection speed, resource conservation and time and labor saving, and enables disinfectant to sufficiently contact the scalpel when the first motor is started to rotate and a disinfection tank is driven to rotate.