The present invention relates to an edible fungus composition for prevention and treatment of diseases, which can effectively solve the problem of prevention and treatment of diseases and maintenance of physical body. The edible fungus composition is produced by including in weight percentage, 8-10% of fungus, 9-11% of straw mushroom, 7-9% of mushroom, 9-11% of champignon, 11-13% of gold needle mushroom, 10-12% tremella, 12-14% of Ganoderma lucidum, 7-9% of pleurotus ostreatus, 8-10% of Hericium, 2-3% of spice, 2-3% of flavoring and 4-6% of water, wherein, the total amount is 100%. The technical program of the invention includes: firstly cutting the fungus, straw mushrooms, mushrooms, champignons, gold needle mushroom, tremella, Ganoderma lucidum, Pleurotus ostreatus and Hericium into strips or blocks; and then adding spices, flavorings and water, placing in a high-pressure cooker, cooking at a high-temperature 120-150 DEG C for 5-10 minutes, cooling, canning or bottling, or bagging to obtain the edible fungus composition. The invention has reasonable formula, convenient consumption, delicious taste, and integration of medical and edible application, and the edible fungus composition is nutrient-rich and a major innovation in the fungus applications.