The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating PICC (Peripherally Inserted Central Catheter) phlebothrombosis and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention is prepared from the following raw materials in weight ratio: ligusticum wallichii, the root of red-rooted salvia, leech, pangolin, fructus amomi, centipede, caulis Spatholobi, lycopodium clavatum, poria cocos, oldenlandia diffusa, oriental wormwood, frankincense, astragalus membranaceus, dandelion, liquorice, honeysuckle, safflower carthamus, peach kernel, Chinese angelica, the fruit of Chinese wolfberry, pericarpium citri reticulatae, lumbricus, medicated leaven, golden cypress, radix paeoniae alba and semen coicis. The traditional Chinese medicine composition disclosed by the invention is the pure traditional Chinese medicine preparation, has the advantages of low cost, obvious curative effect, steady pharmacological effect, no toxic and side effect and adverse reaction and non-recurrent after healing, and is simple to prepare and has wide market application prospect.