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Traditional Chinese medicine enteric oral liquor using leech extractive as active component, and its preparation method

A technology of enteric-coated preparations and active ingredients, applied in the field of medicine, can solve the problems of low absorption of hirudin, poor efficacy and the like

Inactive Publication Date: 2007-02-14
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Similar to other peptide and protein drugs, hirudin is less absorbed after oral administration and has poor efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation method of enteric-coated tablet of the present invention:

[0022] Tablet prescription:

[0023] Leech 1000g

[0024] Starch 120g

[0025] 5% starch slurry appropriate amount

[0026] Makes 1000 pieces

[0027] Coating Solution Prescription:

[0028] PVAP 10%

[0029] Diethyl phthalate 4%

[0030] Talc 2%

[0031] Add acetone / ethanol (1:1) to 100%

[0032] Preparation:

[0033] 1. Take the leech medicinal material, crush it, soak it in appropriate amount of water, add vitamin C-Na, adjust the pH between 4.8-5.2, reflux extraction at 60°C for 1-1.5 hours, filter, and the filtrate alcohol precipitation twice, 24 hours each time, The first alcohol precipitation concentration is 70%, the second alcohol precipitation concentration is 85%, filter to remove the residue, the filtrate is recovered under reduced pressure until it has no alcohol smell, and the dry powder is obtained by low-temperature vacuum drying or freeze-drying, which is the leech. Ex...

Embodiment 2

[0038] The preparation method of enteric-coated capsule of the present invention:

[0039] prescription:

[0040] Leeches 3000g

[0041] Dextrin 90g

[0042] Starch 30g

[0043] Magnesium Stearate 1.5g

[0044] Enteric-coated capsule shell appropriate amount

[0045] A total of 1000 capsules were made

[0046] Preparation:

[0047] 1. Take the leech medicinal material, crush it, soak it in appropriate amount of water, add vitamin C-Na, adjust the pH between 4.8-5.2, reflux extraction at 60°C for 1-1.5 hours, filter, and the filtrate alcohol precipitation twice, 24 hours each time, The first alcohol precipitation concentration is 70%, the second alcohol precipitation concentration is 85%, filter to remove the residue, the filtrate is recovered under reduced pressure until it has no alcohol smell, and the dry powder is obtained by low-temperature vacuum drying or freeze-drying, which is the leech. Extract the active ingredient.

[0048] 2. After mixing the active extract...

Embodiment 4

[0050] The preparation method of enteric-coated capsule of the present invention:

[0051] Prescription of pellet core:

[0052] Leech 100g

[0053] Microcrystalline Cellulose 180g

[0054] 80% ethanol solution appropriate amount

[0055] A total of 1000 capsules were made

[0056] Coating Solution Prescription:

[0057] HPMCAS 8%

[0058] PvP 3%

[0059] Glycerin 2%

[0060] Brown Iron Oxide 2%

[0061] water to 100%

[0062] Preparation:

[0063] 1. Take the leech medicinal material, crush it, soak it in appropriate amount of water, add vitamin C-Na, adjust the pH between 4.8-5.2, reflux extraction at 60°C for 1-1.5 hours, filter, and the filtrate alcohol precipitation twice, 24 hours each time, The first alcohol precipitation concentration is 70%, the second alcohol precipitation concentration is 85%, filter to remove the residue, the filtrate is recovered under reduced pressure until it has no alcohol smell, and the dry powder is obtained by low-temperature vacuum ...

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PUM

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Abstract

An orally taken enteric Chinese medicine in the form of tablet, capsule, dripping pill, or soft capsule for treating unstable angina pectoris, acute myocardial infarction, cerebral haemorrhage, etc and preventing deep phlebothrombosis is prepared from leech. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention belongs to the field of medicine, and relates to a kind of leech as raw material, which is prepared by extracting active ingredients through a certain process, which can be used for the treatment of unstable angina, acute myocardial infarction, cerebral hemorrhage and other diseases; it can also be used for the prevention of deep vein thrombosis Various enteric-coated pharmaceutical preparations for symptoms such as the formation of angioplasty and vascular reocclusion after angioplasty and their preparation methods. Background technique: [0002] Leeches are highly specialized annelids, first recorded in my country's "Shen Nong's Materia Medica", commonly known as leeches. The Chinese Pharmacopoeia includes 3 kinds of leeches, Japanese medical leeches, and willow leaf leeches. Traditional Chinese medicine believes that it has the effects of breaking blood, expelling blood stasis, dredging menstrual flow, and benefiting water passages. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61K9/20A61K9/48A61P9/10A61P7/02A61K35/62
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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