A data processing system includes first and second processing nodes and response logic coupled by an interconnect fabric. A first coherence participant in the first processing node is configured to issue a memory access request specifying a target memory block, and a second coherence participant in the second processing node is configured to issue a probe request regarding a memory region tracked in a memory coherence directory. The first coherence participant is configured to, responsive to receiving the probe request after the memory access request and before receiving a systemwide coherence response for the memory access request, detect an address collision between the probe request and the memory access request and, responsive thereto, transmit a speculative coherence response. The response logic is configured to, responsive to the speculative coherence response, provide a systemwide coherence response for the probe request that prevents the probe request from succeeding.