68 results about "Gonadal hormones" patented technology

A complex is provided for the treatment of neurogenic conditions having the formula:where R1 isM is a metal ion Ca(II), Mg(II), Cu(II) or Ni(II); n is an integer 1 or 2; R is BBB peptide, transferrin, membrane transporter peptide, TAT peptide, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptidegluconate, L-lactate, L-leucine, L-tryptophan, and L-glutamate; and R is coupled to M through a carboxylate moiety. Magnesium(II) represents the preferred metal ion as magnesium is known to have neuroprotective effects. The metal ion is in part chelated by a non-steroidal anti-inflammatory drug that does not inhibit platelet activity and includes salicylate and ibuprofenate. The complex also includes a ligand operative in transport across the blood brain barrier. A process for making an inventive complex includes the stoichiometric addition of ligands containing carboxylate groups to a solution of the metal ion. In instances where the metal ion is magnesium(II), a stoichiometric ratio of 1:1:1 is found between the non-steroidal anti-inflammatory ligand:magnesium(II):transporter ligand.

A compound of the formulawhere R1 is H, C1–C4 alkyl and OH; R2 in is H, C1–C4 alkyl and OH; R3 is H and C1–C4 alkyl; R4 is H and C1–C4 alkyl; n is an integer between 0 and 2 inclusive; R5 is a nullity, NHR7C(O)—, C6H4—, C6H4—O—; R7 is C2–C6 alkyl; and R6 is a moiety capable of crossing the blood brain barrier and is as a free compound serotonin, dopamine, blood brain barrier (BBB) peptide, membrane translocating peptide, TAT peptides, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptidegluconate, transferrin, glucosylamine, amino saccharin, saccharin ester, lactylamine, leucine, tryptophan, amino glutamate and amino cholines.

The invention discloses a fusion protein capable of inducing and activating cancer targeting T-cells as well as a preparation method and application of the fusion protein. The fusion protein contains peptide acting with cancer cells as well as costimulatory molecules B7.1, wherein the peptide acting with the cancer cells is selected from a transforming growth factor-alpha, an epidermal growth factor, a vascular endothelial growth factor, gonadotropinreleasing hormone or gastrin-releasing peptide. The fusion protein has a targeting function; the fusion protein can act with VEGFR, EGFR, GnRH-R, or GRP-R respectively on one hand and interact with corresponding receptors CD28 and CTLA-4 expressed on the T-cells, therefore the targeting of the T-cells is positioned at the periphery of the cancer cells greatly expressing VEGFR, EGFR, GnRH-R, or GRP-R. Proven by experiments, the fusion protein can restrain the growth of tumors and cause cancer cells to apoptosis.

The invention relates to a decapeptide derivative with LHRH receptor antagonism activity and actions of restricting a pituitarium to secrete gonadotrophins and restricting a gonad to secrete steroid hormones, a preparation method thereof, a medicine composition containing the decapeptide derivative and the application of the medicine composition on treating prostatic cancer, endometrial cancer, interrelated sex hormone dependence diseases relative to reproduction, contraception, and the like.

The present invention relates to agonists and antagonists of gonadotropin-releasing hormone-2 (GnRH-2), which regulates the activity of GnRH-2 by specifically binding to GnRH-2 receptors, and uses thereof. The pharmaceutical compositions comprising the GnRH-2 agonists and antagonists according to the present invention are useful for the treatment of reproductive physiology diseases and steroid-related cancer cells because they specifically bind to the GnRH-2 receptors, and they are also usefully applicable to the raising industry of non-mammalian animals, i.e., birds and fish.

The present invention relates to agents and methods for the modulation of gonadotropin hormones and their receptors, including methods of treating gonadotropin disorders and conditions and screening and development of therapies. Specifically, the present invention relates to modulation of gonadotropin hormones through the inhibition of activity of exoloop 1, exoloop 2 and exoloop 3 of gonadotropin receptors.

The invention relates to a method for analyzing the content of ginsenoside in a ten-ingredient Xiangdeer capsule, and belongs to the technical field of traditional Chinese medicine formulae. The ten-ingredient Xiangdeer capsule gives full play to the value of each traditional Chinese medicine, and has the effects of soothing liver-qi stagnation, softening hardness to dissipate stagnation and the like. The pharmacodynamic material basis of the ginseng is ginsenoside, and the ginsenoside has an adjusting effect on the neuroendocrine function of the pituitary-gonad axis; the ginsenoside can excite pituitary to secrete gonadotropin, promote biosynthesis of DNA and protein synthesis related zymoprotein, increase gonad activity, and balance positive and negative feedback functions of neuroendocrine through a bidirectional regulation effect on pituitary-gonad axis so as to achieve the purpose of reducing estradiol which is abnormally increased. Mammary gland cell proliferation controlled by ovarian hormones is inhibited. According to the method, the internal components of the traditional Chinese medicine are selected as internal standards by adopting a quantitative analysis of multi-components by single marker, and the content of the components to be detected is calculated by measuring the relative correction factor RCF between the traditional Chinese medicine and other components to be detected, so that the use amount of reference substances is reduced, and the cost is saved.

The invention relates to a method for detecting early pregnancy of sheep. The method comprises the following steps of: collecting sheep blood or urine from the seventh day to the fourteenth day aftermating of ewes; inserting sheep chorionic gonadotropin HCG detection test paper into serum or urine for 5-10 seconds, and after 15-18 minutes, indicating that a detection result is invalid if a test paper quality control line C does not develop color and a detection line T develops color; indicating that an HCG level of ewes is low if the quality control line C develops color and the detection line T does not develop color; comparing developed colors with an HCG colorimetric card if the quality control line C and the detection line T both develop colors; indicating that the ewes are not pregnant if HCG is smaller than 10 mIU / ml; indicating that the ewes are possibly pregnant and need to be continuously detected twice if the HCG is greater than or equal to 10 mIU / ml, and indicating that theewes are pregnant and have living embryos if the HCG of twice detection rises and the HCG detected later is 1-2 times of the HCG detected last time; and indicating that ewes are pregnant but encounter embryo damage if the HCG of twice detection is kept unchanged or decreased, and taking miscarriage prevention measures or stopping pregnancy.

The present invention relates to decapeptide derivatives with LHRH receptor antagonistic activity, the function of inhibiting pituitary gland secretion of gonadotropin and gonadal secretion of steroid hormones, their preparation method, their pharmaceutical composition and their role in the treatment of prostate cancer and Use for sex hormone dependence-related diseases related to reproduction.