73 results about "Flow perfusion" patented technology

According to one embodiment, a blood flow perfusion analyzing apparatus includes tissue and arterial TCC calculation units, first and second making units, a deconvolution unit and a blood flow information calculation unit. The tissue TCC calculation unit obtains tissue TCCs. The arterial TCC calculation unit calculates an arterial TCC. The first making, unit makes first sets, starting from a first time in which elements corresponding to the tissue are arrayed one-dimensionally, based on the tissue TCCs. The second making unit makes a second set, starting from a second time after the first time, in which elements corresponding to the artery are arrayed two-dimensionally, based on the arterial TCC. The deconvolution unit calculates transfer functions of the tissue based on the first and second sets. The blood flow information calculation unit calculates information on a blood flow perfusion based on the transfer functions.

A non-invasive hand-held treatment imaging probe for treatment of acute blood flow disturbances and states of low blood perfusion. The treatment imaging probe is operable to emit high intensity therapeutic mechanical acoustic waves while under ultrasonic imaging guidance. The probe has a substantially rigid application surface, sized to enable seating within a rib space of a patient (i.e. for cardiac applications), comprising the combination of an engagement face of an ultrasonic imaging transducer and an application end of a high powered therapeutic actuator operable in about the 1-500 kHz (and preferably 1-150 kHz) range. Treatment imaging probe can be used as an adjunct to thrombolytic therapy in the treatment of acute thrombotic vascular obstructions, such as in acute myocardial infarction, or alternatively to enhance localized delivery of angiogenic agents or other useful medications to targeted vascular regions.

A blood perfusion separation detecting and imaging method for a bone surface capillary comprises the following steps: programming transmitting and receiving beams meeting the bone surface multimode leakage Lamb wave condition, constructing bone surface multimode leakage Lamb wave microbubble mother wavelets, then achieving mode separation detection of incidence, reflection and multi-mode leakage Lamb wave aliasing RF (Radio Frequency) echo signals by adopting the bone surface multimode leakage Lamb wave microbubble wavelet method, and finally achieving radiography imaging and blood perfusion parameter imaging of the transformation capillary for the bone surface multimode leakage Lamb wave microbubble wavelets. The blood perfusion separation detecting and imaging method can effectively improve the resolution and the radiography tissue ratio and suppress aliasing interference of the bone surface multimode leakage Lamb waves to radiography imaging of the bone surface tissue capillary, thereby achieving great significance on early diagnosis and evaluation of malignant bone tumors.

The invention discloses a fluorescence navigation system based on photometric feedback and an intraoperative fluorescence navigation adjustment method thereof. A beam splitter is additionally arrangedon an imaging light path, a photoelectric detector detects the intensity of excitation light which enters the imaging light path and is reflected by tissue, a distance is obtained through operation and fed back to the system, and exposure parameters of a camera can be adjusted in real time, so that the system truly reflects the fluorescence change condition in the blood perfusion process under the condition of adapting to fluorescence imaging at different imaging distances.

The invention relates to a human microcirculation blood perfusion detecting instrument and method. The detecting instrument comprises a laser module, a light probe, a detecting module, a signal processing module and a user interface module. The laser module emits laser signals of preset wavelength to the light probe. The light probe transmits the laser signals emitted by the laser module to human tissue and transmits light signals reflected by the human tissue to the detecting module. The detecting module converts the light signals transmitted by the light probe into corresponding electric signals and transmits the electric signals to the signal processing module. The signal processing module extracts Doppler shift signals from the electric signals and calculates blood perfusion according to the Doppler shift signals. The user interface module displays the blood perfusion visually. The detecting instrument can help doctors or related medical staff find the situation in time and take effective treatment measures when microcirculation disturbance happens to a patient, and therefore health of the patient is ensured.

The invention discloses a bedside pulmonary ventilation-blood perfusion impedance tomography method based on saline radiography, an image monitoring device based on the method, an image monitoring system based on the method and a pulmonary embolism diagnosis system based on the method. By means of the method, the quality of blood perfusion imaging is improved, and dead space ventilation%, intrapulmonary shunt% and regional ventilation-blood match% are calculated according to blood perfusion imaging, so that the practicability is higher. Pulmonary embolism can be diagnosed by means of the method, the sensitivity is 90.9%, the specificity is 98.6%, and the method has very high clinical application value.

The invention relates to an anti-bedsore air cushion bed, and belongs to the field of medical instruments. The air cushion bed comprises two layers of detachable inflatable mattresses, a tissue bloodflow and pressure synchronous acquisition module, a data transmission module, a controller module, a power supply module and an alarm module. The two layers of detachable inflatable mattresses comprise turning-over layers and multi-independent air bag layers, the turning-over layers achieve the left-right turning-over function of a patient, each multi-independent air bag layer is formed by arranging a plurality of air bag units, and the mattress is divided into three areas including a head area, a back and hip area and a leg area. A tissue blood flow and pressure synchronous acquisition moduleis arranged in each multi-independent air bag layer air bag unit to synchronously acquire the tissue blood flow perfusion condition of the local part of the human body and the surface pressure of thecorresponding part, so that the real-time pressure and skin microcirculation detection of the part of the bedridden patient can be realized, and a blood flow perfusion amount and body surface pressure curve is established; and a safety pressure threshold value is determined, a pressure and time safety area is determined, and airbag pressure adjustment is performed according to a detection resultfeedback formula. The turning-over air cushion and the nursing bed are combined for use, bedsores are prevented for a patient, and meanwhile nursing personnel can push the patient to walk conveniently.

The invention provides an intelligent ECMO treatment device based on a rolling type blood pump and a control method of a system.The intelligent ECMO treatment device comprises a vein cannula, the rolling type blood pump, a membrane lung and an arterial cannula, the vein cannula is connected to an inlet of the rolling type blood pump through a first connecting pipe, and the rolling type blood pump is connected to an outlet of the artery cannula through a second connecting pipe; a venous pressure sensor is arranged on the first connecting pipe; an outlet of the rolling type blood pump is connected to an inlet of the membrane lung through an arteriovenous bridge tube, an artery overpressure sensor is arranged on the arteriovenous bridge tube, the membrane lung is further connected with an air and oxygen mixer and a temperature changing device, an outlet of the membrane lung is connected to the arterial cannula through a second connecting tube, and the arterial cannula is connected with the air and oxygen mixer through a second connecting tube. The venous pressure sensor and the artery overpressure sensor are respectively connected with the rolling type blood pump through the central processing unit. According to the invention, the perfusion pressure can be intelligently and accurately controlled, and finally constant-flow perfusion is achieved.

The invention discloses a perfusion and dilation balloon system. The perfusion and dilation balloon system comprises a perfusion and dilation balloon and a delivery conduit, wherein a perfusion chamber for pouring blood flow is arranged on the perfusion and dilation balloon; a closed balloon pressure chamber is formed by the infusion chamber and the perfusion and dilation balloon; a balloon wire guiding chamber is arranged in the balloon pressure chamber; a conduit pressure chamber communicated with the balloon pressure chamber is arranged in the delivery conduit; a conduit wire guiding chamber communicated with the balloon wire guiding chamber is arranged in the conduit pressure chamber. According to the perfusion and dilation balloon system disclosed by the invention, the balloon pressure chamber is filled with liquid with a certain pressure to dilate the perfusion and dilation balloon, thus forming a hollow cylindrical pipeline body; the hollow perfusion chamber guarantees the perfusion of the blood blow while blood vessel walls are supported and dilated by a balloon wall of the perfusion and dilation balloon; when serious lesion of blood vessel openings, aortic dissecting aneurysm and main blood vessel opening occur, effective blood flow perfusion channels can be effectively provided for important blood vessel opening parts and corresponding visceral organs, thereby guaranteeing further intervention and surgical treatment.

The invention discloses a method for extracting exosome from amniotic mesenchymal stem cells and application of the exosome. The exosome is obtained through the steps of amnion separation, washing, epithelial cell removal, shearing, digestion, centrifugation, second-layer suspension taking, resuspension, inoculated culture, subsequent extraction preparation and the like. When the exosome is applied to a medicine for promoting angiogenesis and osteogenesis, vascular endothelial cell aggregation and angiogenesis can be achieved, a microcirculation is reconstructed, blood perfusion is increased,lost of other functions is not caused, and the application prospect is promising. According to the method, the cell extraction process is optimized, the amniotic stem cell extraction efficiency is higher, the purity is higher, and on the premise that more cells are obtained, it can be guaranteed that more exosomes are obtained.

The invention provides a perfusion balloon catheter with a one-way valve. The perfusion balloon catheter comprises a balloon body part; the balloon body part comprises an inner cavity tube and a plurality of balloons arranged around the outer surface of the inner cavity tube; far-end balloon tube legs of the multiple balloons are in contact with the tube wall of the inner cavity tube; and the one-way valve is arranged between the inner cavity tube and the balloon part of the balloon. Compared with the prior art, the balloon body part of the perfusion balloon catheter is formed by bundling the multiple balloons, and a hollow quasi-cylindrical shape is formed after expansion; meanwhile, the one-way valve is arranged in the cavity and used for simulating valve leaflets in a heart valve and conducting one-way blood perfusion, after the balloons are opened, the one-way valve is started, opening and closing operation is not needed, the structure is stable, and the valve leaflet function can be achieved repeatedly; and in addition, through the design of the bundling balloon, the expected function can be met, and meanwhile, the difficulty of the balloon forming process is lowered.

The invention relates to a stem cell combined growth factor injection for promoting angiogenesis in ischemic tissue, a preparation method and a use method thereof. The body’s protective response to peripheral tissue ischemia is relatively complex. Although a single growth factor intervention is effective, it cannot complete this process; although stem and progenitor cell transplantation can improve the vascular density and blood perfusion of ischemic tissue, the main source of cells is bone marrow. There are serious limitations in the acquisition of umbilical cord blood, umbilical cord blood, etc., and the in vivo viability of cells is extremely limited, which seriously affects its therapeutic effect. The invention utilizes human basic fibroblast growth factor to intervene in adipose mesenchymal stromal cells, and cooperates with vascular endothelial cell growth factor to promote angiogenesis in ischemic tissue. The present invention overcomes the benefit limitation of single factor or cell therapy, ensures sufficient stem cell acquisition, and improves the survival ability and angiogenesis effect of transplanted cells, thereby further improving blood perfusion of ischemic lower limbs and improving limb survival Rate.

The invention discloses an aortic intracavitary double-horizontal-sacculus blockage pressurized infusion system. The system comprises a main catheter, an aortic arch sacculus, an aortic arch sacculus injecting catheter, an aortic distal sacculus and an aortic distal sacculus injecting catheter, wherein a main catheter infusion outlet is formed in the top end of the main catheter, and the tail end, introduced to the outside of the body, of the main catheter is a first tail end injecting hole; the aortic arch sacculus is connected to the part below the top end of the main catheter; the aortic arch sacculus injecting catheter attaches to the main catheter; the top end of the aortic arch sacculus injecting catheter communicates with the aortic arch sacculus; the bottom end, introduced to the outside of the body, of the aortic arch sacculus injecting catheter is a second tail end injecting hole; the aortic distal sacculus is connected to the middle section part of the main catheter; the aortic distal sacculus injecting catheter attaches to the main catheter; the top end of the aortic distal sacculus injecting catheter communicates with the aortic distal sacculus; and the bottom end, introduced to the outside of the body, of the aortic distal sacculus injecting catheter is a third tail end injecting hole. For the aortic intracavitary double-horizontal-sacculus blockage pressurized infusion system, the rescuing resuscitating success rate for patients suffering from hemorrhagic sudden cardiac arrest can be improved by improving the effective continuous blood perfusion for the important organs including the heart, the brain, the kidney and the like.

The invention discloses a brain perfusion state classification device and method, equipment and a storage medium. The method comprises the following steps: a transceiver module is used for acquiring neck blood flow data from ultrasonic data acquisition equipment; a processor is used for determining brain perfusion data corresponding to the neck blood flow data based on the neck blood flow data and a mapping relation between the neck blood flow data and the brain perfusion data; and based on blood perfusion characteristics of a plurality of brain regions in the brain perfusion data, brain perfusion states of the plurality of brain regions are classified. According to the device, the corresponding brain perfusion data can be predicted through the neck blood flow data, and then the brain perfusion state of each brain area can be more comprehensively and accurately distinguished based on the blood flow perfusion characteristics (such as the brain blood flow) in the brain perfusion data, so that the acquisition mode of the brain perfusion state is greatly simplified, the application scene of brain examination is expanded, the accuracy of cerebral blood flow and brain function evaluation results is improved, and doctors are assisted in completing brain examination.

The invention discloses a portable tissue blood flow perfusion monitor based on abdominal impedance spectral parameters, comprising a master control module, a programmable constant-current source, animpedance electrode array, a wide-band abdominal impedance spectral data acquisition circuit, an AD (analog / digital) converter, a buffer unit, a control panel, a display screen and a battery power supply module; when powered by the battery power supply module, the master control module controls the programmable constant-current source to output an excitation current signal of required frequency point, which is applied to the human abdomen through exciting electrodes in an impedance electrode array; the wide-band abdominal impedance spectral data acquisition circuit transmits analog values of real parts and imaginary parts of impedances corresponding to exciting frequencies to the AD converter to carry out digital-analog conversion; the converted data of real parts and imaginary parts of the impedances are transmitted to the buffer unit; the master control module calculates a tissue blood flow perfusion value through a tissue blood flow perfusion real-time dynamic estimation procedure,and the tissue blood flow perfusion value is displayed through a display. The portable tissue blood flow perfusion monitor based on abdominal impedance spectral parameters is suitable for providing real-time dynamic monitoring for tissue blood flow perfusion of prehospital shocked patients.

The invention relates to a evaluation method for moyamoya disease operation curative effect, which comprises the following steps of: respectively performing three-dimensional ordered subset expectation maximization reconstruction on pre-operation and post-operation SPECT (Single Photon Emission Computed Tomography) images of the same subject by combining 99TCm-bisemi-ethyl ester single photon emission computed tomography and a computed tomography cerebral blood flow perfusion imaging technology, and importing the images into an SPECTProc workflow; firstly, defining and testing a Talairach boundary; after processing is finished, setting a subject reference group, setting voxel data as correlation, and normalizing the voxel data to the maximum value of the whole brain; and comparing the SPECT brain imaging differences before and after the operation of the same subject, and evaluating the operation curative effect of the moyamoya disease. The preoperative and postoperative visual perfusion results and quantitative perfusion ROI results of the same subject can be visually displayed. The analysis may cover the entire cerebral cortex. The analysis method is visual, easy to learn and use, simple and convenient to operate and more objective and real in analysis result. Statistical analysis can be performed on quantitative data and qualitative data at the same time, it is proved through statistical basis to be superior to visual evaluation, and the credibility of a conclusion is guaranteed.

The invention provides an analysis algorithm of macular region choroid membrane blood capillary density. The analysis algorithm of the macular region choroid membrane blood capillary density comprisesthe steps that blood vessel artifacts of a choroid membrane blood capillary layer are removed by using the dissection characteristic of no blood perfusion in a retina outer layer; and the shielding action of a retina RPE is removed by extracting structural information of CC in optical coherence tomography, blood information in a retina deep vascular plexus is used as a threshold value setting basis of the CC, and the problems of retina artifacts, RPE shielding and threshold value setting subjectivization existing in existing CC blood capillary density calculation are solved.

The invention provides an auxiliary pump blood catheter pump, which relates to the technical field of medical apparatus and instruments, and comprises a fixed support assembly, a fluid tube and an axial flow impeller, a blood inlet and a blood outlet are formed in the fluid pipe, the fixed supporting assembly is connected with the pipe wall of the fluid pipe, and the fixed supporting assembly has a reversible unfolding posture and a reversible storage posture; and the product can be implanted into a blood transfusion organ through a catheter, large surgical operations such as thoracotomy are not needed, trauma is small, and recovery is fast. When the device is applied to the aorta connected with the left ventricle, the blood inlet of the fluid tube is communicated with the left ventricle, and the device is used for improving the hemodynamic performance in the heart, increasing the cardiac output or assisting a high-risk cardiac surgery; when applied to the descending aorta, the product can improve the kidney perfusion pressure in the descending aorta and is used for preventing renal failure caused by acute heart failure; when applied to the interiors of superior vena cava, inferior vena cava or pulmonary arteries and the like, the pressure in blood vessels can be increased, and blood perfusion of all blood transfusion organs is improved.

The invention discloses a real-time monitoring method and system for blood perfusion at different depths of the skin. The method mainly comprises the following steps of 1, splitting reflected light ofa to-be-monitored skin area; 2, collecting image information of the reflected light, and calculating a blood volume signal of each pixel point in a to-be-monitored skin area image along with time change; 3, collecting image information of each spectral section of transmission light, and calculating a spectral pulse wave signal under each spectral section in the to-be-monitored skin area image; and 4, performing cross-correlation operation on the pulse wave signal of each spectral section and the corresponding blood volume signal to obtain blood perfusion images of the to-be-monitored skin area at different depths. According to the invention, monitoring of blood perfusion at different depths of skin tissues is realized, and the application range of blood perfusion monitoring based on an imaging method is greatly expanded.

The invention discloses a system for noninvasive monitoring of cerebral blood flow. The system comprises a signal source, a sensor unit, a signal collecting and processing unit and a storage unit. The invention provides a non-contact magnetic induction type bedside long-time real-time cerebral blood flow monitoring system with high sensitivity, cerebral blood flow perfusion abnormity can be found in time, emergency measures are taken for control, and the non-contact magnetic induction type bedside long-time real-time cerebral blood flow monitoring system has important significance on effective treatment and reduction of cerebral function damage and death rate and improvement of the treatment level of cardiovascular patients.

The invention relates to a survival myocardial evaluation method, which is used for evaluating based on gating SPECT myocardial perfusion development myocardial functions in combination with myocardial perfusion, and comprises the following steps: firstly, acquiring an examination image by adopting gating SPECT myocardial perfusion development, and reconstructing to obtain a left ventricular minoraxis image, a left ventricular horizontal major axis image and a left ventricular vertical major axis image; then carrying out semi-quantitative scoring on blood perfusion uptake of the left ventricular myocardial segment, and judging a perfusion reduction segment; quantitatively evaluating to obtain the blood perfusion uptake ratio of each segment of the left ventricular myocardium; analyzing the reconstructed gated SPECT myocardial perfusion imaging, respectively obtaining a ventricular wall movement score and a thickening rate score of each myocardial segment, and finally substituting theparameters into an evaluation model for calculation. Evaluation is carried out based on gated SPECT myocardial perfusion imaging myocardial functions in combination with myocardial perfusion, and themethod is particularly suitable for evaluating survival myocardium of coronary heart disease heart failure patients before blood supply reconstruction and guiding clinical treatment decisions.

The invention discloses a method for evaluating physiotherapy efficacy. The method is characterized by comprising steps of firstly, acquiring speckle images of physiotherapy sites of patients; secondly, acquiring speckle image contrast of the speckle images; thirdly, acquiring blood flow perfusion degrees prior to physiotherapy and time-dependent change curves of blood flow perfusion degrees in physiotherapy procedures according to the speckle image contrast; fourthly, comparing the blood flow perfusion degrees prior to the physiotherapy with the time-dependent change curves of the blood flowperfusion degrees in the physiotherapy procedures. The method has the advantages that the method is implemented by the aid of speckle blood flow perfusion degree imaging technologies, accordingly, theblood flow perfusion degrees of the physiotherapy sites can be quickly and accurately acquired by the aid of the method, and physiotherapy effects can be evaluated by the aid of the method.

An observation cell arrangement for flow perfusion of a sample to be examined, the arrangement comprising a flow cell (21) having a cavity therein to receive the sample, the flow cell (21) arranged to receive a flow of fluid through the cavity that is directed over the sample from a cavity inlet (22) to a cavity outlet (23), the cavity inlet (22) associated with a fluid supply line, and a first flow supply path (24) connected to the fluid supply line via a valve (39), the first flow supply path (24) adapted to receive pressure from a pressure source comprising a pressure reservoir (29) to drive fluid flow through the cavity at a desired flow rate.

The invention relates to a device, a system and a method for detecting plantar blood oxygen. The device for detecting the plantar blood oxygen comprises a detection body, a blood flow detection module and a main control module, wherein the detection body is used for placing two feet of a target object; the blood flow detection module is arranged on the detection body, and is used for detecting a blood flow PI (Perfusion Index) and a plantar blood oxygen saturation degree SpO2 of the target object; the main control module is arranged in the detection body, and is used for controlling the blood flow detection module to detect the blood flow PI and the plantar blood oxygen saturation degree SpO2. According to the device disclosed by the invention, the plantar blood oxygen saturation degree SpO2 of a patient can be monitored, and a detection result cannot be influenced by exterior factors; the blood flow PI can be detected at the same time, and the monitoring on cardiovascular diseases and the old is valid as well; data processing analysis can be carried out through cloud server linkage, remote health monitoring is realized, and a health report can be generated and provided for the patient for reference.

The invention belongs to the field of screening of effective components of traditional Chinese medicines and preparations of the effective components, and relates to a drug delivery system with tumormicroenvironment adjustment and a targeting function and application thereof in pharmacy, in particular to application in pancreatic tumor treatment. The invention discloses a nano delivery system. Nanoparticles which are constructed from a medical polymer polylactic acid material, have good biocompatibility and biodegradability and have the effects of regulating a tumor microenvironment and increasing blood perfusion are adopted, a section of functional polypeptide CGKRK is covalently bonded to the surface, the CGKRK can target heparan sulfate which is highly-expressed in the tumor microenvironment, and the tumor targeting property is improved; and natural drug monomers are physically entrapped in hydrophobic cores of the nanoparticles through an emulsifying solvent evaporation method, sothat the solubility of the drug is improved, and the in-vivo circulation time of the drug is prolonged. The established drug-loaded nano system can inhibit the excessive activation of CAFs, reduce the proportion of M2 macrophages, effectively improve the tumor microenvironment and increase the accumulation of the drug at the tumor site.

The present invention provides a diagnostic method comprising continuously monitoring and transmitting urine output and urine flow rates of a catheterized patient to means which correlate the same with at least one of renal perfusion, renal function, fluid status, polyuria, oleguria, hypoperfusion, hemorrhage shock and GFR.

The invention relates to an acquisition method and system for blood perfusion of the hypothalamus and the pituitary. The method comprises the following steps: constructing a three-dimensional space model of the hypothalamus and the pituitary; collecting a blood perfusion magnetic resonance image of an individual brain, and acquiring a blood perfusion image of the individual brain, wherein the blood perfusion image comprises a cerebral blood flow parameter, a time parameter and a cerebral blood volume parameter; importing the blood flow perfusion image into the three-dimensional space model; and according to the blood perfusion model of the hypothalamus and the pituitary, acquiring perfusion parameters corresponding to all times, wherein the perfusion parameters comprise cerebral blood flow and a cerebral blood volume. According to the invention, the accuracy of blood perfusion parameter acquisition is improved.