The invention discloses white grape wine and a preparation method thereof. The white grape wine is prepared from the following raw materials: fresh grape, saccharose, towel gourd, Chinese yam, Youngia japonica, loosestrife, pollen pini, Eucalyptus globulus Labill., common tetragonia herb, Lithocarpus pachylepis A. Camus, naringin, an eurycoma longifolia extract, Anqi grape wine yeast, kojic acid, pectinase, lipase, protease, lysozyme, skim milk and chitosan. A product is complete in nutrition, simple to prepare, short in period, reduced in cost, low in alcoholic strength, sour and sweet in mouthfeel and high in healthcare function; the taste and nutrition of the grape are kept by low temperature fermentation; the fruit, the vegetables and the traditional Chinese medicines are added by primary and secondary fermentation, the taste and nutrition are increased, the wine body stability is enhanced, an extraction process is simplified, an extraction ratio is increased, the cost is lowered, the healthcare function is improved, the white grape wine can obviously relieve rheumatism symptom, can prevent and resist cancer, is skincare, anti-aging, and capable of promoting the gastrointestinal function, enhancing immunity and preventing cardiovascular and cerebrovascular diseases, and after being subjected to comprehensive clarification treatment, a wine body is clarified and good in stability.