33 results about "Ethyl nicotinate" patented technology

The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.

The invention provides an iridium (III) complex. A 2-phenylethyl isonicotinate derivative is used as the main ligand, and 3,6-di-tert-butyl -9-(4-(4,5)-dimethyl-2-(pyrid-2-yl)-1H-imidazol-1-yl) butyl)-9H-carbazole is used as the auxiliary ligand. The iridium (III) complex has good light stability, large Stokes shift, high luminous efficiency and aggregation-induced emission property, and can be applied to the field of cell imaging.

The invention relates to a method for synthesizing an important intermediate 2-chloro-3-amino-4-methylpyridine for an anti-AIDS medicament Nevirapine, and belongs to the technical field of organic synthesis. The method comprises the following process steps that: ethyl cyanoacetate and acetone are dehydrated and condensed to generate a condensation compound I under the action of a catalyst; dimethyl formamide, dimethyl sulfate and sodium methoxide solution react to generate N,N-dimethylformamiade dimethyl acetal (N,N-dimethyl formamide A), and then the N,N-dimethylformamiade dimethyl acetal reacts with the condensation compound I to generate conjugated enamine, namely a condensation compound II; the condensation compound II is cyclized by hydrochloric acid and ethanol to form a cyclic compound 2-chloro-4-methyl-ethyl nicotinate; the 2-chloro-4-methyl-ethyl nicotinate is ammonolyzed by ammonia gas to form 2-chloro-4-methyl-niacinamide; and the 2-chloro-4-methyl-niacinamide is subjected to Hofmann degradation reaction to form the 2-chloro-3-amino-4-methylpyridine. Compared with the prior synthesizing method, the method of the invention has the remarkable characteristic of reducing thereaction steps, and is suitable for large-scale industrialized production; the molar total yield of the five-step reaction is improved to 27 percent from the prior 24 percent; and the purity of the product reaches over 99 percent.

The invention provides a method for synthesizing 4-bromo-6-chloronicotinic aldehyde, which relates to the field of medicinal chemistry. The synthetic route is to react 4,6-dichloronicotinic acid ethyl ester and 4-methoxybenzylamine to obtain 6-chloro-nicotinic acid 4‑((4‑methoxybenzyl) amino) nicotinic acid ethyl ester, 6‑chloro‑4‑((4‑methoxybenzyl) amino) nicotinic acid ethyl ester and trifluoroacetic acid react to give 4‑amino ‑6‑chloronicotinic acid ethyl ester, 4‑amino‑6‑chloronicotinic acid ethyl ester and tert-butyl nitrite react with benzyltriethylammonium bromide to give 4‑bromo‑6‑chloronicotinic acid ethyl ester, 4 ‑Bromo‑6‑chloronicotinic acid ethyl ester reacts with diisobutylaluminum hydride under certain conditions to obtain 4‑bromo‑6‑chloronicotinol, and 4‑bromo‑6‑chloronicotinol is further catalyzed by manganese dioxide The following reaction is carried out to obtain the target product 4-bromo-6-chloronicotinic aldehyde; the synthetic method disclosed by the invention has mild reaction conditions, reduces production costs, and is suitable for large-scale industrial production.