33 results about "Ethyl nicotinate" patented technology

The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.

Disclosed is a method for the conversion of a compound of formula 3 to a compoundof formula 4, wherein R is an acetyl group or an alcohol-protecting group. The process involves reacting 3 with a triflating agent in the presence of a nicotinate (3-pyridinecarboxylate) of a C1-C4 alcohol, preferably methyl nicotinate (methyl 3-pyridinecarboxylate) or ethyl nicotinate (ethyl 3-pyridinecarboxylate), to give 4. The method can be conveniently used in a process for the preparation of Abiraterone or Abiraterone acetate.

The invention provides an iridium (III) complex. A 2-phenylethyl isonicotinate derivative is used as the main ligand, and 3,6-di-tert-butyl -9-(4-(4,5)-dimethyl-2-(pyrid-2-yl)-1H-imidazol-1-yl) butyl)-9H-carbazole is used as the auxiliary ligand. The iridium (III) complex has good light stability, large Stokes shift, high luminous efficiency and aggregation-induced emission property, and can be applied to the field of cell imaging.

The invention relates to a method for synthesizing an important intermediate 2-chloro-3-amino-4-methylpyridine for an anti-AIDS medicament Nevirapine, and belongs to the technical field of organic synthesis. The method comprises the following process steps that: ethyl cyanoacetate and acetone are dehydrated and condensed to generate a condensation compound I under the action of a catalyst; dimethyl formamide, dimethyl sulfate and sodium methoxide solution react to generate N,N-dimethylformamiade dimethyl acetal (N,N-dimethyl formamide A), and then the N,N-dimethylformamiade dimethyl acetal reacts with the condensation compound I to generate conjugated enamine, namely a condensation compound II; the condensation compound II is cyclized by hydrochloric acid and ethanol to form a cyclic compound 2-chloro-4-methyl-ethyl nicotinate; the 2-chloro-4-methyl-ethyl nicotinate is ammonolyzed by ammonia gas to form 2-chloro-4-methyl-niacinamide; and the 2-chloro-4-methyl-niacinamide is subjected to Hofmann degradation reaction to form the 2-chloro-3-amino-4-methylpyridine. Compared with the prior synthesizing method, the method of the invention has the remarkable characteristic of reducing thereaction steps, and is suitable for large-scale industrialized production; the molar total yield of the five-step reaction is improved to 27 percent from the prior 24 percent; and the purity of the product reaches over 99 percent.

The invention provides a method for preparing tazarotene without the participation of cuprous iodide. First, a palladium catalyst and triphenylphosphine are added to a specific organic solvent, stirred, replaced by nitrogen, and then added 4,4-dimethyl Benzothiopyran-6-yl-acetylene, ethyl 6-chloronicotinate and acid-binding agent are reacted. The method is environmentally friendly, the catalyst is easy to recycle, no waste water containing heavy metals is produced, and the reaction time is shorter and the reaction temperature is lower than the prior art. The product obtained by the method has high yield, high purity and stable quality.

The invention relates to the field of medicine and chemical industry. Aims at solving problems of high trifluoromethylation reagent toxicity, or high cost, complicated reaction, and low conversion rate existing in synthesizing reactions of trifluoromethylation similar compounds, the invention provides a synthesizing method of 2-trifluoromethyl-3-fluoropyridin. The method comprises the steps that: (2) with 2-trifluoromethyl ethyl nicotinate as a raw material, 2-trifluoromethyl-3-aminopyridine is produced through a reaction; and (2) the product obtained in the step (1) is subjected to a reaction with fluoboric acid, such that 2-trifluoromethyl-3-fluoropyridin is obtained. According to the invention, the raw materials have low cost, and are easy to obtain. Also, post treatment is simple. The method is suitable for laboratory small-scale preparation, and is suitable for large-scale industrialized production.

The invention provides a method for synthesizing 4-bromo-6-chloronicotinic aldehyde, which relates to the field of medicinal chemistry. The synthetic route is to react 4,6-dichloronicotinic acid ethyl ester and 4-methoxybenzylamine to obtain 6-chloro-nicotinic acid 4‑((4‑methoxybenzyl) amino) nicotinic acid ethyl ester, 6‑chloro‑4‑((4‑methoxybenzyl) amino) nicotinic acid ethyl ester and trifluoroacetic acid react to give 4‑amino ‑6‑chloronicotinic acid ethyl ester, 4‑amino‑6‑chloronicotinic acid ethyl ester and tert-butyl nitrite react with benzyltriethylammonium bromide to give 4‑bromo‑6‑chloronicotinic acid ethyl ester, 4 ‑Bromo‑6‑chloronicotinic acid ethyl ester reacts with diisobutylaluminum hydride under certain conditions to obtain 4‑bromo‑6‑chloronicotinol, and 4‑bromo‑6‑chloronicotinol is further catalyzed by manganese dioxide The following reaction is carried out to obtain the target product 4-bromo-6-chloronicotinic aldehyde; the synthetic method disclosed by the invention has mild reaction conditions, reduces production costs, and is suitable for large-scale industrial production.