The invention relates to the technical field of medicine preparations, and particularly relates to a pradaxa-containing microemulsion preparation and a preparation method thereof. The pradaxa-containing microemulsion preparation is prepared by combination of a certain proportion of a surfactant, a cosurfactant, an oil phase, a water phase and a moderate amount of a stabilizer, a suspension aid, a sweetener and a preservative, the prepared pradaxa-containing microemulsion preparation is oil-in-water type, the particle size is in the range of 200-400 nm, appearance is clear transparent uniform, and stability is good. The microemulsion preparation, compared with an oral solid preparation, has the advantages of low production cost, simple preparation process and the like, after oral administration, dissolution of pradaxa in the gastrointestinal tract is increased, the bioavailability is improved, and the pradaxa-containing microemulsion preparation has the good market prospect.