Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dabigatran-containing solid dispersion and preparation method as well as application thereof

A technology of solid dispersion and dabigatran etexilate, applied in the field of medicine, can solve problems such as difficulty in ensuring the exertion of drug efficacy, and achieve the effects of improving drug bioavailability, accelerating dissolution rate, and improving water solubility

Inactive Publication Date: 2015-05-27
QINGDAO HUANGHAI PHARM CO LTD
View PDF5 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is difficult to guarantee the efficacy of the common dispersion preparation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dabigatran-containing solid dispersion and preparation method as well as application thereof
  • Dabigatran-containing solid dispersion and preparation method as well as application thereof
  • Dabigatran-containing solid dispersion and preparation method as well as application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Mix and grind 3g of dabigatran etexilate and 20g of povidone K30 for 10min, add the resulting mixture into 100mL of anhydrous methanol and stir for 15min, transfer the obtained solution to a rotary evaporator for rotary evaporation, and wait until it is concentrated to 10mL Take it out and place it in an oven to dry for 4 hours, and the obtained solid is crushed and passed through an 80-mesh sieve to obtain a solid dispersion containing dabigatran etexilate benzenesulfonate.

Embodiment 2

[0036] 5g dabigatran etexilate mesylate, 10g povidone K30, and 10g povidone K90 were dissolved in absolute ethanol, and then the solution was spray-dried by spray drying equipment to obtain a composite solid dispersion, and further After drying for 1 hour, the residual solvent was removed, and the obtained solid was passed through an 80-mesh sieve to obtain a solid dispersion containing dabigatran etexilate mesylate.

Embodiment 3

[0038] Measure 200mL of anhydrous methanol, add 3ml of Tween 80, 30g of polyethylene glycol 2000, fully shake and dissolve, then add 5g of dabigatran etexilate, stir for about 20min, pour the obtained solution into a rotary evaporator, and concentrate to 15ml When it is taken out, it is dried in an oven, and the obtained solid is pulverized and passed through an 80-mesh sieve to obtain a solid dispersion of dabigatran etexilate butanedisulfonate.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicines and specifically discloses a dabigatran-containing solid dispersion and a preparation method as well as application thereof. The solid dispersion comprises a dabigatran-containing active substance and a carrier material, wherein the hydrophilic high-molecular polymer accounts for 20%-98% of mass of the solid dispersion and the carrier material is a hydrophilic high-molecular polymer. The preparation of the solid dispersion is low in cost and excellent in technical reproducibility.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a solid dispersion containing dabigatran etexilate and its preparation and application. Background technique [0002] Atrial fibrillation (AF) is the most common arrhythmia disease clinically. The investigation shows that the prevalence of atrial fibrillation in my country is as high as 0.77%, and the prevalence shows a trend of increasing significantly with age. With the increasingly prominent problem of population aging in my country, the prevalence of atrial fibrillation will continue to increase. Cardiogenic stroke (mainly ischemic stroke) is the most serious complication of atrial fibrillation, with a high rate of death and disability. Therefore, stroke prevention is very important for patients with atrial fibrillation. The basis of stroke prevention is anticoagulant therapy. Warfarin is the oral anticoagulant drug with the most abundant clinical evidence and the most comm...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4439A61K47/34A61K47/32A61P7/02A61K47/10
Inventor 牟琳琳闫敏李普成刘晓华胡杰
Owner QINGDAO HUANGHAI PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com