53 results about "Chlorophyll derivatives" patented technology

The invention discloses a method for extracting chlorophyll and preparing sodium ferrous chlorophyll from silkworm excrement, belonging to the field of traditional Chinese medicine. In the method, high-purity sodium ferrous chlorophyll and chlorophyll derivatives are prepared from the silkworm excrement by using an ultramicro smash and extraction technology under the conditions of medium-concentration ethanol and temperature control according to the process steps of extraction, saponification, purification, ferrugination and alkalization, thereby improving the production efficiency. The effect of the method is obviously superior to that of the prior art.

The invention belongs to the technical field of production of sodium copper chlorophyllin and in particular relates to a method for producing sodium copper chlorophyllin through supercritical purification. The method for producing sodium copper chlorophyllin through supercritical purification comprises the following steps: (1) saponifying; (2) washing; (3) copperizing; and (4) purifying, namely purifying copperized chlorophyll by adopting supercritical carbon dioxide; and (5) obtaining the finished product. According to the method, the copperized chlorophyll is purified by adopting a supercritical technology, the particularity of a molecular structure of chlorophyll derivatives is overcome, and the yield of the copperized chlorophyll is greatly improved, so that the process of producing the sodium copper chlorophyllin is efficient and friendly to the environment.

The invention belongs to the field of new auxiliary materials and new dosage forms of medicine preparations and relates to a chemotherapeutic drug-photosensitizer co-assembled nanoparticles and construction thereof. A chemotherapeutic drug is an anthracycline chemotherapeutic drug selected from mitoxantrone, doxorubicin or epirubicin; a photosensitizer is a porphyrin photosensitizer selected fromchlorine e6, hematoporphyrin monomethyl ether or a chlorophyll derivative, wherein the molar ratio of the chemotherapeutic drug to the photosensitizer is 3:1-1:3. A certain quantity of the chemotherapeutic drug and the photosensitizer or a mixture of the chemotherapeutic drug, the photosensitizer and PEG is dissolved in a proper quantity of organic solvent, and the solution is slowly dropwise added to water while stirring to form uniform nanoparticles spontaneously. The preparation process is simple, enlarged production is easy, particle size is small and uniform, and the nanoparticles can beenriched at tumor parts through a reinforced permeation retention effect; the nanoparticles have ultrahigh drug loading capacity and can reduce related toxicity of auxiliary materials; and surface modification is easy, and the circulation time of the nanoparticles in blood can be prolonged by PEG modification.

The invention discloses a preparation method of a natural chlorophyll iron calcium salt and further obtains the natural chlorophyll iron calcium salt (also known as iron chlorophyllin calcium). In the method, the chlorophyll iron calcium salt is prepared from a chlorophyll iron sodium salt and a calcium slat used as raw materials through one-step direct substitution, wherein the chlorophyll iron sodium salt and the calcium slat are respectively dissolved in water according to the weight ratio; the pH value of reaction solution is 8-9; water solution of the Ca salt is slowly added into solution of the chlorophyll iron sodium salt, magnetic stirring is performed at the speed of about 1000r / min, and the reaction is performed fully at room temperature; and aging, separation and drying at the temperature of 50 DEG C-80 DEG C are further performed, thereby obtaining the black (dark brown) chlorophyll iron calcium salt. By adopting the method, the easily available raw material, namely the natural chlorophyll iron sodium salt is used for preparing a chlorophyll derivative, namely the chlorophyll iron (II) calcium salt, thereby realizing the simultaneous supplementation of iron and calcium for a human body and having no toxicity or side effects. The preparation method is simple and the yield is high. The chlorophyll iron calcium salt can be used as a medicament or a food additive and has very broad application prospects in the aspects of foods, medicines and the like.

A composition and kit for hair dyeing comprising a first liquid containing an alkaline ingredient and an oxidation dye and a second liquid containing an oxidant wherein the improvement being the addition of a chlorophyll derivative, such as sodium iron chlorophyllin, into the first liquid.

The invention relates to the technical field of photoelectric materials, in particular to a biologic solar cell having a three-layer chlorophyll structure and a preparation method thereof. The biologic solar cell having the three-layer chlorophyll structure comprises a transparent conductive glass cathode, an electron transport layer, a dye-sensitized mesoporous semiconductor layer, a light simulation system I layer, a light simulation system II layer and a metal anode in order from bottom to top. The light simulation system I layer and the light simulation system II layer are phyllins films with different energy levels, and the energy level of the light simulation system I layer is higher than the energy level of the light simulation system II layer; and the dye-sensitized mesoporous semiconductor layer is anti-form 3<2>-carboxyl-pyropheophorbide acid-a and anti-form 8<2>-carboxyl-pyropheophorbide acid-a co-sensitized mesoporous titanium dioxide. The biologic solar cell having the three-layer chlorophyll structure has the highest photoelectric conversion efficiency up to 4.1% to achieve more than three-times photoelectric conversion efficiency compared to a dual-layer battery. Thepreparation method is simple in preparation process and low in production cost.

The present invention relates to a process for treating an oil comprising a chlorophyll derivative. In particular, the present disclosure relates to an improved process for removing impurities, including chlorophyll derivatives and / or trace metals, from an oil using an adsorbent comprising a silica treated with an alkali earth metal oxide, such as magnesium oxide. The process comprises contacting the oil with the adsorbent, wherein the pH of the silica is about 7 or greater, including from about 7 to about 10. The process may further comprise contacting the oil with a polypeptide having decolorase activity or a composition comprising the polypeptide, prior to contact with the adsorbent.

The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and / or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO<−>, COS<−>, SO3<−>, PO3<2−>, COOH, COSH, SO3H, and / or PO3H2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.

The invention provides a novel nanometer titania / chlorophyll derivative dye and a preparation method thereof. The preparation method comprises the following steps: cleaning and drying leaf stems of fresh plant; processing the leaf stems with a cupric sulfate solution to obtain a chlorophyll-stable plant raw material; then preparing the pre-treated plant raw material into plant powder; adding the plant powder into ethanol water; performing light-proof sealing and stirring; conducting ultrasonic oscillation; filtering and taking the filtrate; concentrating the filtrate to obtain a chlorophyll extracting solution; adding a sodium hydroxide and ethanol solution into the chlorophyll extracting solution to saponify chlorophyll; adding a sulfate solution; adding water for dilution; filtering to obtain a solid chlorophyll derivative; finally, dissolving the solid chlorophyll derivative into ethanol water; performing quick stirring; adding a nanometer titania solution dropwise; performing intensive stirring to obtain the nanometer titania / chlorophyll derivative dye. The prepared dye is high in absorbency, good in stability, high in water solubility and excellent in color fastness, and a fabric dyed by the dye is bright and long-lasting in color and high in wash resistance and light fastness.

The invention relates to pyropheophorbide-a methyl ether compounds, and a preparation method and application thereof. The compounds have the structure (I) in the specification. The invention relates to the fields of photodynamic therapy and photosensitive drugs (also called photosensitizers or photodynamic drugs), particularly a chlorophyll derivative photosensitizer and a preparation method thereof, and application of the chlorophyll derivative photosensitizer in the field of medicine. The photodynamic drug provided by the invention has the advantages of stable chemical properties, high solubility in water, and very high photodynamic activity, and can be used as a drug for the photodynamic diagnosis and treatment of tumors, retinal macular degeneration, actinic keratosis, nevus flammeus, condylomata acuminata and other diseases.

The present invention belongs to the field of a medicine and relates to the use of a chlorophyll derivative for improving muscle microcirculation disorder, in particular the use of the chlorophyll derivative for preparation of a medicine for treatment and / or prevention of muscle microcirculation disorder. The chlorophyll derivative of the present invention, such as a chlorophyll extract and a silkworm extract, has the good effect on improving muscle microcirculation disorder. The chlorophyll derivative can also comprehensively prevent and improve the muscle microcirculatory disorder by actingin a plurality of links. Moreover, the toxic and side effects of the chlorophyll derivative are improved, the chlorophyll derivative is suitable for a wide range of people and is safe, and can be applied to treat children, the elderly, pregnant women and lactating women. In addition, a preparation method of the chlorophyll derivative and the method for preparing the medicine are relatively simple,and the cost is effectively controlled.

The present invention belongs to the field of a medicine and relates to the use of a chlorophyll derivative for improving microcirculation disorder, in particular the use of the chlorophyll derivativefor preparation of a medicine for treatment and / or prevention of microcirculation disorder. The chlorophyll derivative of the present invention, such as a chlorophyll extract and a silkworm extract,has the good effect on improving microcirculation disorder. The chlorophyll derivative can also comprehensively prevent and improve the microcirculatory disorder by acting in a plurality of links. Moreover, the toxic and side effects of the chlorophyll derivative are improved, the chlorophyll derivative is suitable for a wide range of people and is safe, and can be applied to treat children, the elderly, pregnant women and lactating women. In addition, a preparation method of the chlorophyll derivative and the method for preparing the medicine are relatively simple, and the cost is effectivelycontrolled.

In one aspect, provided herein is a process for refining a plant oil, comprising a step of contacting the oil with an enzyme which is capable of hydrolysing chlorophyll or a chlorophyll derivative, wherein the enzyme is contacted with the oil in the presence of at least 0.1% by weight phospholipid.

The invention relates to the technical field of virus control, in particular to an antiviral composition as well as a preparation method and application thereof. The antiviral composition is prepared from the following raw materials: ravensara leaf essential oil or eucalyptus essential oil, oregano essential oil, tea tree essential oil, a chlorophyll derivative and glycerol monolaurate. The antiviral composition achieves the effects of capturing, inhibiting and killing viruses in different aspects and levels through combination of pharmaceutical effects and physical effects, and has broad-spectrum, efficient and multi-aspect antiviral effects. Moreover, featured by small dosage, strong effect, lasting action time and safety in use, the antiviral composition can greatly reduce the probability that an organism is infected with respiratory viruses.

The invention discloses a morphology genetic derivative composite material. A chloroplast-like spherical structure with the diameter of 200 -500 nm is formed by a transition metal-nitrogen-carbon matrix and 20-80 wt% of transition metal oxide nanoparticles. The preparation method of the morphology genetic derivative composite material comprises the following steps: (1) crushing plant leaves, then,putting the crushed plant leaves into an extracting solution for grinding, purifying the chloroplast by using a differential centrifugation method after the mixture is filtered with gauze, and then,soaking with a glutaraldehyde phosphate buffer solution to fix a microstructure of the chloroplast; (2) soaking the chloroplast with the structure fixed in an HCl aqueous solution and a methanol solution of transition metal acetate, sequentially, obtaining a transition metal chlorophyll derivative, and freeze-drying the transition metal chlorophyll derivative after being centrifugally cleaned; and(3) calcining the frozen-dried chloroplast under an inert gas atmosphere or a vacuum condition to obtain the morphology genetic derivative composite material. The morphology genetic derivative composite material in the invention has a stable and controllable micro-nano structure and can be applied to fuel cell electrode catalysts.

The invention provides cationic tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one positively charged group and / or at least one basic group that is converted to a positively charged group under physiological conditions, preferably Bchls having an onium group derived from a N-containing aliphatic or heterocyclic radical such as ammonium, guanidinium, imidazolium, pyridinium, and the like or a phosphonium, arsonium, oxonium, sulfonium, selenonium, telluronium, stibonium, or bismuthonium group, or a basic group that is converted to such onium groups under physiological conditions, said groups being bound to one or more of the positions 17<3>, 13<3> and 3<2> of the Bchl molecule by ester or amide bond. The Bchls are useful for photodynamic therapy and diagnosis.

The invention discloses a fenton-like reagent for degrading organic pollutants and application of the fenton-like reagent, applies a water-soluble transition metal chlorophyll derivative (TMCD) to thefenton-like reaction for degrading pollutants and belongs to the field of water pollution treatment. The TMCD can be reacted with various oxidants in an aqueous solution, and the fenton-like reagentcan efficiently degrade various persistent pollutants without the illumination condition and has good degradation effect in a range that a pH value is greater than 3. By using a method provided by theinvention, various refractory pollutants can be rapidly and efficiently degraded, and the effect is obviously superior to the effect of the existing fenton and fenton-like water treatment technologies.

The present invention is directed to a biocompatible and biodegradable natural disperse dye for dyeing polyester fabrics which is dispersed in water and derived from green plants. The disperse dye contains as the active dye compound an acid bewchlorophyllin derivative such as acid form Mg-chlorophyllin or acid form Cu-chlorophyllin. The disperse dye of the present invention can be used for the dyeing of polyester fabrics by traditional methods in concentrations ranging from 0.01% to 20% on weight of fibers (OWF), thus providing a dyed fabric with good color strength and good fastness to light, washing and rubbing, under conditions of dye exhaustion of greater than 90%.

The invention belongs to the technical field of sodium copper chlorophyllin production, and concretely relates to a method for producing sodium copper chlorophyllin through supercritical purification. The method for producing sodium copper chlorophyllin through supercritical purification comprises the following steps: 1, saponifying; 2, washing; 3, carrying out copper formation; 4, purifying obtained copper chlorophyllin by adopting supercritical carbon dioxide; and 5, preparing a finished product. The method adopts a supercritical technology to purify the copper chlorophyllin, so the particularity of the molecular structure of chlorophyll derivatives is overcome, the copper chlorophyllin yield is greatly improved, and the sodium copper chlorophyllin production process is efficient and environmentally-friendly.

An ingestible formulation for a malodor eliminator for animals that works systemically and comprises a formulation of a chlorophyll derivative combined with Spirulina and alfalfa wherein the chlorophyll derivative is at least 90 percent of the formulation is presented. In the preferred embodiment, the chlorophyll derivative is chlorophyllin. The formulation may be a capsule, liquid, tablet, or gelcap when in its usable form with the preferred embodiment being in a capsule formulation. When produced in tablet form, the formulation may also include a tableting agent. The formulation has a dissolution time generally sufficient to allow the formulation to pass an animal's stomach before beginning to breakdown. The formulation is dose dependent and will vary depending on the size of the animal to which it is given.

The invention belongs to the technical field of production of sodium copper chlorophyllin and in particular relates to a method for producing sodium copper chlorophyllin through supercritical purification. The method for producing sodium copper chlorophyllin through supercritical purification comprises the following steps: (1) saponifying; (2) washing; (3) copperizing; and (4) purifying, namely purifying copperized chlorophyll by adopting supercritical carbon dioxide; and (5) obtaining the finished product. According to the method, the copperized chlorophyll is purified by adopting a supercritical technology, the particularity of a molecular structure of chlorophyll derivatives is overcome, and the yield of the copperized chlorophyll is greatly improved, so that the process of producing the sodium copper chlorophyllin is efficient and friendly to the environment.

The invention provides a bacterial chlorophyll derivative, a preparation method and medical applications thereof, and specifically relates to a bacterial chlorophyll derivative represented by a formula (I), a preparation method and a pharmaceutically acceptable salt thereof, and applications of the bacterial chlorophyll derivative and the pharmaceutically acceptable salt in photodynamic therapy oftumors, wherein each substituent in the formula (I) is defined in the specification.

The invention belongs to the field of medicine, and relates to the use of chlorophyll derivatives for improving muscle microcirculation disorders, in particular to the use of chlorophyll derivatives in preparing medicines for treating and / or preventing muscle microcirculation disorders. The chlorophyll derivatives of the present invention, such as chlorophyll extracts and silkworm excrement extracts, have a good curative effect on improving muscle microcirculation disorders. The chlorophyll derivatives can also comprehensively prevent and improve muscle microcirculation disturbance through their functions in multiple links. Moreover, the toxic and side effects of the chlorophyll derivatives are improved, the applicable population is wide and safe, and can be applied to treat children, the elderly, pregnant women and lactating women. In addition, the preparation method of the chlorophyll derivative and the process applied to the preparation of medicine are relatively simple, and the cost is effectively controlled.

The invention belongs to the field of licorice, wheat and jujube soup preparation processes, and particularly relates to a licorice, wheat and jujube soup preparation process and production equipment, S1, 50 kg of licorice, 100 kg of wheat and 150 kg of jujube are extracted by dry weight, the raw materials are mixed together, the mixture is put into a mixer, water with the weight 8 times that of the medicinal materials is added, boiling extraction is performed twice, an extracting solution is filtered by a 200-mesh sieve, and a filtrate is obtained; s2, concentrating the filtrate under reduced pressure in an environment with the vacuum degree of-0.06 Mpa and the temperature of 70 DEG C until the relative density is 1.20-1.25 (50 DEG C) and the water amount is 8 times that of the filtrate; the chlorophyll derivative (CPD) separated from the mixed light wheat silkworm excrement has an inhibition effect on in-vitro liver cancer tissue culture cells, in-vitro tests show that 0.04 g (crude drug) ml or 0.01 g (crude drug) / ml of silkworm excrement water extract has an anti-bovine thrombin effect, the coagulation time of human fibrin can be remarkably prolonged, and anxiety depression is inhibited.

The present invention belongs to the field of a medicine and relates to the use of a transition metal-chelated chlorophyll derivative for improving microcirculation disorder, in particular the use ofthe transition metal-chelated chlorophyll derivative for preparation of a medicine for treatment and / or prevention of microcirculation disorder. The transition metal-chelated chlorophyll derivative ofthe present invention, such as a chlorophyll extract and a silkworm extract, has the good effect on improving microcirculation disorder. The transition metal-chelated chlorophyll derivative can alsocomprehensively prevent and improve the microcirculatory disorder by acting in a plurality of links. Moreover, the toxic and side effects of the transition metal-chelated chlorophyll derivative are improved, the transition metal-chelated chlorophyll derivative is suitable for a wide range of people and is safe, and can be applied to treat children, the elderly, pregnant women and lactating women.In addition, a preparation method of the transition metal-chelated chlorophyll derivative and the method for preparing the medicine are relatively simple, and the cost is effectively controlled.

The invention discloses a multifunctional toilet paper sterilization spray and preparation and use methods thereof. The multifunctional toilet paper sterilization spray comprises the following components in parts by weight: 50-80 parts of chlorophyll derivatives, 10-20 parts of borneol, 20-30 parts of cyclodextrine, 5-10 parts of 75% alcohol, 5-10 parts of polysorbate-80 and 80-90 parts of a chlorine-containing solution. The preparation method comprises the following steps: preparing a colorless chlorine-containing solution A of which the effective chlorine concentration is 300-800ppm; mashingborneol into powder, pouring the powder into alcohol with the concentration of 75%, and obtaining liquid B after the borneol is completely dissolved; pouring polysorbate-80 into the liquid B, and uniformly stirring to generate faint yellow liquid C; sequentially pouring cyclodextrine and chlorophyll derivatives into the chlorine-containing solution A, and uniformly stirring to generate green liquid D; pouring the liquid C into the liquid D, and stirring and mixing to finally generate multifunctional liquid E; and sterilizing the liquid E, and filling a sterilized light-proof spray bottle withthe sterilized liquid E. The sterilization spray is used in cooperation with toilet paper and can achieve the effects of cleaning, sterilization, blood cooling, wound healing and the like on the anus.

The invention belongs to the field of medicine, and relates to the use of chlorophyll derivatives for improving ear microcirculation disorders, in particular to the use of chlorophyll derivatives in preparing medicines for treating and / or preventing ear microcirculation disorders. The chlorophyll derivatives of the present invention, such as chlorophyll extracts and silkworm excrement extracts, have good curative effects on improving ear microcirculation disorders. The chlorophyll derivatives can also comprehensively prevent and improve ear microcirculation disturbance by acting in multiple links. Moreover, the toxic and side effects of the chlorophyll derivatives are improved, the applicable population is wide and safe, and can be applied to treat children, the elderly, pregnant women and lactating women. In addition, the preparation method of the chlorophyll derivative and the process applied to the preparation of medicine are relatively simple, and the cost is effectively controlled.

The present invention provides a method for detecting a phytol-free chlorophyll derivative in a sample, comprising a step of detecting a fluorescent signal associated with the phytol-free chlorophyll derivative, wherein a fluorescent signal associated with chlorophyll or a phytol-containing chlorophyll derivative in the sample is quenched. The method may be used for quantifying activity of chlorophyllases and related enzymes in a sample without solvent fractionation of substrate and product.

The invention discloses a state-derived composite material, which consists of a transition metal-nitrogen-carbon matrix and 20-80 wt% transition metal oxide nanoparticles to form a chloroplast-like spherical structure with a diameter of 200-500 nm. The preparation method of the relic-derived composite material is as follows: (1) after crushing the plant leaves, put them into the extract and grind them, filter them through gauze, and then use differential centrifugation to purify the chloroplasts, and then soak them in glutaraldehyde phosphate buffer to remove the chloroplasts. Fixing the microstructure of chloroplasts; (2) immersing the fixed chloroplasts in HCl aqueous solution and transition metal acetate methanol solution successively to obtain transition metal chlorophyll derivatives, which are centrifuged and then freeze-dried; (3) freeze-dried The dried chloroplasts are calcined in an inert gas atmosphere or under vacuum conditions to obtain the remains-derived composite material. The state-derived composite material of the invention has a stable and controllable micro-nano structure and can be applied as a fuel cell electrode catalyst.