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33 results about "Bacteriochlorophyll" patented technology

Bacteriochlorophylls (BChl) are photosynthetic pigments that occur in various phototrophic bacteria. They were discovered by C. B. van Niel in 1932. They are related to chlorophylls, which are the primary pigments in plants, algae, and cyanobacteria. Groups that contain bacteriochlorophyll conduct photosynthesis, but do not produce oxygen. They use wavelengths of light not absorbed by plants or Cyanobacteria. Replacement of Mg2+ with protons gives bacteriophaeophytin (BPh), the phaeophytin form.

Conjugates of rgd peptides and porphyrin or (bacterio) chlorohyll photosynthesizers and their uses

Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and normeoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.
Owner:YEDA RES & DEV CO LTD

Conjugates of rgd peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses

Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.
Owner:YEDA RES & DEV CO LTD

De novo synthesis of bacteriochlorins

A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
Owner:NORTH CAROLINA STATE UNIV

RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and Imaging of Necrotic tumors

RGD-chlorophyll and RGD-bacteriochlorophyll conjugates that home and accumulate in necrotic tumor domains much longer than in tumor non-necrotic domains are provided for use in minimally invasive tumor-targeted imaging, tumor-targeted photodynamic therapy, and / or on-line prognosis of necrotic tumors.
Owner:YEDA RES & DEV CO LTD

Process for preparing chlorins and their pharmaceutical uses

The disclosed subject matter includes methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and bacterioclorins designed for the photodynamic therapy (PDT) of hyperproliferative tissues such as tumors, hyperproliferative blood vessels and other disorders or abnormalities that are responsive to PDT. In particular, the economical large-scale synthesis of stable chlorins and bacteriochlorins is described. Their properties were tailored to meet those of ideal photosensitizers for PDT. In another embodiment, pharmaceutical compositions and methods of therapy for systemic administration are provided. In a further embodiment, pharmaceutical compositions and methods of therapy for topical administration are also provided. Further provided is a method of labeling a target tissue and providing an image of that tissue by fluorescence of magnetic resonance imaging.
Owner:UNIVE DE COIMBRA +1

De novo synthesis of bacteriochlorins

A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula IIto produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
Owner:NORTH CAROLINA STATE UNIV

Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals

A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy to treat hyperproliferative tissue. The preferred compounds have the structural formula:where R1, R2, R2a R3, R3a R4, R5, R5a R6, R7, R7a, and R8 cumulatively contain at least two functional groups that will complex or combine with an MR imaging enhancing element or ion. The compound is intended to include such complexes and combinations and includes the use of such compounds for MR imaging and photodynamic therapy treatment of tumors and other hyperproliferative tissue.
Owner:HEALTH RES INC

Water-soluble anionic bacteriochlorophyll derivatives and their uses

The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and / or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO<−>, COS<−>, SO3<−>, PO3<2−>, COOH, COSH, SO3H, and / or PO3H2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.
Owner:YEDA RES & DEV CO LTD

Hydroporphyrin beads with narrow fluorescence emissions

Provided are fluorescent micro particles and / or nano particles that have a polymeric matrix and at least one porphyrinic macrocycle associated therewith. The porphyrinic macrocycles associated with the presently disclosed fluorescent micro particles and / or nano particles are in some embodiments selected from the group consisting of porphyrins (including 17, 18-didehydrophorbines), chlorins (including phorbines), bacteriochlorins (including bacteriophorbines), and isobacteriochlorins (including isobacteriochlorins containing a fused E ring). In some embodiments, the porphyrinic macrocycles havestructures selected from Formulas I and H. Also provided are populations made up of a plurality of distinct fluorescent micro particles and / or nano particles, methods of making and using the same, sets of separately detectable fluorescent micro particles and / or nano particles and methods for preparing and using the same, porphyrinic macrocycle-containing dyads conjugated to particles and methodsfor using the same to calibrate multi-laser flow cytometers, align and / or calibrate confocai fluorescence microscopes, and / or differentially labeling cells and / or other bio-molecules, and bio-molecules such as antibodies, fragments, and derivatives thereof covalently conjugated to the presently disclosed fluorescent micro particles and / or nano particles and / or to the presently disclosed porphyrinic macrocycle-containing dyads.
Owner:NIRVANA SCI INC

Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them

Novel C-132-COXR1, C-172-COXR2 and C-132-COXR1, C-172-COXR1 derivatives of chlorophyll and bacteriochlorophyll compounds are provided wherein X is O, S or N and R1 and R2, the same or different, may be an optionally substituted hydrocarbyl, amino acid, peptide, protein or saccharide radical. The compounds are for use in photodynamic therapy (PDT), for diagnosis of tumors, and for killing cells and infectious agents such as bacteria and virus, both in biological products and in living tissues.
Owner:YEDA RES & DEV CO LTD

RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and Imaging of Necrotic tumors

RGD-chlorophyll and RGD-bacteriochlorophyll conjugates that home and accumulate in necrotic tumor domains much longer than in tumor non-necrotic domains are provided for use in minimally invasive tumor-targeted imaging, tumor-targeted photodynamic therapy, and / or on-line prognosis of necrotic tumors.
Owner:YEDA RES & DEV CO LTD

Synthesis of biological agent for gathering nitrate in micro-polluted water body

The invention relates to a removing method for nitrate in a micro-polluted water body and belongs to the field of wastewater treatment. The method comprises the steps that a certain amount of herba houttuyniae, herba incarvller and kudzu are taken and smashed, absolute ethyl alcohol is added, the mixture passes through a chromatographic column, and a mixture composed of chlorophyll a and bacteriochlorophyll is extracted; the mixture is placed into a colorimetric tube with a plug, protein and pectin are added and mixed with the mixture to be even, titration is performed through diethyl ether, and filtration is performed through a filter membrane for sterilization; sodium dihydrogen phosphate and magnesium chloride are dissolved in de-ionized water, and after being stirred and cooled, the solution is added into the chlorophyll a and bacteriochlorophyll mixed liquid sterilized through the filter membrane; succinic acid is added to adjust pH; methanol and ethyl acetate are added into the mixed liquid and stirred, in addition, glutamic acid is added, sterilization is performed, pH is adjusted, cooling is performed, and sterile filtration is performed to obtain colorless supernatant liquid; a sodium thiosulfate solution and a magnesium chloride solution are added into the supernatant liquid, pH is adjusted, and the mixed liquid is cooled, sterilized, mixed and then poured into a sterilized test tube for low-temperature storage out of the sun. Equipment is low in manufacturing cost, running costs are low, and management is easy and convenient; besides, phosphate removal is efficient, low in consumption and free of secondary pollution.
Owner:广州贝山水生态科技有限公司

Catatonic Bacteriochlorophyll Derivatives

ActiveUS20080076748A1Simple methodPreventing and reducing in-stent restenosisAntibacterial agentsBiocideChlorophyll derivativesPhotodynamic therapy
The invention provides cationic tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one positively charged group and / or at least one basic group that is converted to a positively charged group under physiological conditions, preferably Bchls having an onium group derived from a N-containing aliphatic or heterocyclic radical such as ammonium, guanidinium, imidazolium, pyridinium, and the like or a phosphonium, arsonium, oxonium, sulfonium, selenonium, telluronium, stibonium, or bismuthonium group, or a basic group that is converted to such onium groups under physiological conditions, said groups being bound to one or more of the positions 17<3>, 13<3> and 3<2> of the Bchl molecule by ester or amide bond. The Bchls are useful for photodynamic therapy and diagnosis.
Owner:YEDA RES & DEV CO LTD

Synthesis of biological agent for gathering nitrite in micro-polluted water body

The invention relates to synthesis of a biological agent for gathering nitrite in a micro-polluted water body and belongs to the field of wastewater treatment. The method comprises the steps that a certain amount of lalang grass rhizome, selaginella uncinata and monstera rhizome are taken and smashed, absolute ethyl alcohol is added, the mixture passes through a chromatographic column, and a mixture composed of chlorophyll a and bacteriochlorophyll is extracted; the mixture is placed into a colorimetric tube with a plug, agar and gelatin are added and mixed to be even, titration is performed through ethyl acetate, and filtration is performed through a filter membrane for sterilization; sodium hexametaphosphate and zinc chloride are dissolved in de-ionized water, and after being stirred and cooled, the solution is added into the chlorophyll a and bacteriochlorophyll mixed liquid sterilized through the filter membrane; an aluminum sulfate solution is added to adjust pH; formaldehyde and acetone are added into the mixed liquid and stirred, in addition, threonine is added, sterilization is performed, the pH is adjusted, cooling is performed, and sterile filtration is performed to obtain colorless supernatant liquid; a sodium sulfate solution and a magnesium chloride solution are added into the supernatant liquid, pH is adjusted, and the mixed liquid is cooled, sterilized, mixed and then poured into a sterilized test tube for low-temperature storage out of the sun. Raw materials are wide in source and convenient and easy to obtain, the technology is simple, and operation costs are low.
Owner:福建龙骏环保设备有限公司

Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents

Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in macular degeneration. Broadly, the compounds are tetrapyrollic photosensitizer compounds where the tetrapyrollic compound is a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide having 3 to 6 —CH2CONHphenylCH2CH(N(CH2COOH)2))(CH2N(CH2COOH)(CH2CH2N(CH2COOH)2)) groups or esters thereof or complexes thereof with gadolinium(III).
Owner:HEALTH RES INC

Environmentally-friendly method for preparing carotenoids from photosynthetic bacteria that do not produce oxygen

The invention discloses an environment-friendly method for preparing anoxygenic photosynthetic bacterium carotenoids. The method comprises the steps of collecting wet thalli of anoxygenic photosynthetic bacteria, adding the wet thalli to an alkaline low-concentration ethanol-water solution, selectively extracting and removing bacteriochlorophyll rather than the carotenoids in the wet thalli, and extracting the carotenoids in the wet thalli through absolute ethyl alcohol after removing the bacteriochlorophyll. According to the method, the anoxygenic photosynthetic bacterium carotenoids are extracted according to the ethanol-water process, so that the selectivity is good, the purity of the carotenoids is high, operation is easy, and conditions are mild; no other organic solvents are adopted in the whole process except ethanol and water, so that harmful residues of the organic solvents are reduced, the method is environmentally friendly, operation is easy and convenient, and scale production can be easily achieved.
Owner:HUAQIAO UNIVERSITY

A kind of biological preparation method for enriching the content of nitrite in slightly polluted water body

The invention relates to synthesis of a biological agent for gathering nitrite in a micro-polluted water body and belongs to the field of wastewater treatment. The method comprises the steps that a certain amount of lalang grass rhizome, selaginella uncinata and monstera rhizome are taken and smashed, absolute ethyl alcohol is added, the mixture passes through a chromatographic column, and a mixture composed of chlorophyll a and bacteriochlorophyll is extracted; the mixture is placed into a colorimetric tube with a plug, agar and gelatin are added and mixed to be even, titration is performed through ethyl acetate, and filtration is performed through a filter membrane for sterilization; sodium hexametaphosphate and zinc chloride are dissolved in de-ionized water, and after being stirred and cooled, the solution is added into the chlorophyll a and bacteriochlorophyll mixed liquid sterilized through the filter membrane; an aluminum sulfate solution is added to adjust pH; formaldehyde and acetone are added into the mixed liquid and stirred, in addition, threonine is added, sterilization is performed, the pH is adjusted, cooling is performed, and sterile filtration is performed to obtain colorless supernatant liquid; a sodium sulfate solution and a magnesium chloride solution are added into the supernatant liquid, pH is adjusted, and the mixed liquid is cooled, sterilized, mixed and then poured into a sterilized test tube for low-temperature storage out of the sun. Raw materials are wide in source and convenient and easy to obtain, the technology is simple, and operation costs are low.
Owner:福建龙骏环保设备有限公司

A kind of synthetic method of biological preparation for enriching nitrate content in micro-polluted water body

The invention relates to a removing method for nitrate in a micro-polluted water body and belongs to the field of wastewater treatment. The method comprises the steps that a certain amount of herba houttuyniae, herba incarvller and kudzu are taken and smashed, absolute ethyl alcohol is added, the mixture passes through a chromatographic column, and a mixture composed of chlorophyll a and bacteriochlorophyll is extracted; the mixture is placed into a colorimetric tube with a plug, protein and pectin are added and mixed with the mixture to be even, titration is performed through diethyl ether, and filtration is performed through a filter membrane for sterilization; sodium dihydrogen phosphate and magnesium chloride are dissolved in de-ionized water, and after being stirred and cooled, the solution is added into the chlorophyll a and bacteriochlorophyll mixed liquid sterilized through the filter membrane; succinic acid is added to adjust pH; methanol and ethyl acetate are added into the mixed liquid and stirred, in addition, glutamic acid is added, sterilization is performed, pH is adjusted, cooling is performed, and sterile filtration is performed to obtain colorless supernatant liquid; a sodium thiosulfate solution and a magnesium chloride solution are added into the supernatant liquid, pH is adjusted, and the mixed liquid is cooled, sterilized, mixed and then poured into a sterilized test tube for low-temperature storage out of the sun. Equipment is low in manufacturing cost, running costs are low, and management is easy and convenient; besides, phosphate removal is efficient, low in consumption and free of secondary pollution.
Owner:广州贝山水生态科技有限公司

Method for obtaining functionalized polymeric surfaces with photosensitizers, functionalized polymeric material and use thereof

The present invention describes methods for obtaining functionalized polymeric surfaces (MPn-PSm) from polymers or copolymers with appropriate functionalizations (X), which can be a halogen of a leaving group, such as polyvinyl chloride (MP1) and (chloromethyl)polystyrene-Merrifield (MP2), and curcumin photosensitizers (PS1), meso-tetra(aryl)porphyrins, chlorins or bacteriochlorins halogenated and functionalized with nucleophilic groups (PS2), in particular including P2 of the type meso-imidazoyl-porphyrins, chlorins or bacteriochlorins (PS3). The structures of all the photosensitizers in the present application incorporate a functional group (Y), which is a OH, SH or NH2nucleophile. The application also describes the covalent bonding process of the photosensitizers PS1-PS3 to the functional polymeric materials MP1-MP2 by means of a nucleophilic substitution reaction to prepare the MPn-Psm products. The formed products prevent microbial proliferation, which can cause the serious infections that are one of the main causes of death in patients using these devices.
Owner:UNIV DE SAO PAULO +1

Compound pesticide for preventing and treating wheat scab

The invention discloses a compound pesticide for preventing and treating wheat scab. The compound pesticide is prepared from phenamacril, magnesium-containing chlorophyllin salt, bacteriochlorophyll,a selenized carrageenan solution and water, and the mass ratio of the phenamacril, the magnesium-containing chlorophyllin salt, the bacteriochlorophyll, the selenized carrageenan solution and the water is (20-30):(1-2):(1.5-3):(5-20):(50-70). According to the formula for preventing and treating the wheat scab, the effect of preventing and treating the wheat scab can be remarkably improved; the drug resistance of the Fusarium graminearum to the phenamacril is greatly reduced; nutrient elements selenium and magnesium can be provided for growth of wheat, and the bacteriochlorophyll also promotesgrowth of the wheat. Compared with a wheat block field without the compound pesticide, in the same growth environment, a wheat block field utilizing the compound pesticide achieves the growth period shortened by about 10 days, and the average wheat yield increased by 50-100 kg per mu.
Owner:青岛金尔农化研制开发有限公司

Water-soluble anionic bacteriochlorophyll derivatives and their uses

The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and / or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO<−>, COS<−>, SO3<−>, PO3<2−>, COOH, COSH, SO3H, and / or PO3H2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.
Owner:YEDA RES & DEV CO LTD

Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and their applications thereof

The present invention relates to carboxamide halogenated porphyrin derivatives, in particular bacteriochlorin or chlorin, of formula (I) use of the same or a pharmaceutically acceptable salt thereof in photodynamic therapy, where the derivatives are able to detect and exhibit the presence of hyperproliferative disorders and, in the presence of an adequate lighting, to treat the same. The present invention also describes a pharmaceutical composition having the carboxamide halogenated porphyrin derivatives, in particular bacteria-chlorin or chlorin, of Formula (I) or a pharmaceutically acceptable salt thereof, for the treatment of cancer and / or microbial and / or viral infections, in humans or animals.
Owner:LUZITIN SA +1

Multimodality agents for tumor imaging and therapy

A compound that is a conjugate of an antagonist to an integrin expressed by a tumor cell and at least one of a tumor avid tetrapyrollic photosensitizer, a fluorescent dye, and a radioisotope labeled moiety wherein the radioisotope is 11C, 18F, 64Cu, 124I, 99Tc, 111In or GdIII and its method of use for diagnosing, imaging and / or treating hyperproliferative tissue such as tumors. Preferably the photosensitizer is a tumor avid tetrapyrollic photosensitizer, e.g. a porphyrin, chlorin or bacteriochlorin, e.g. pheophorbides and pyropheophorbides. Such conjugates have extreme tumor avidity and can be used to inhibit or completely destroy the tumor by light absorption. The integrin is usually αvβ3, α5β1, αvβ5, α4β1, or α2β1. Preferably, the antagonist is an RGD peptide or another antagonist that may be synthetic such as a 4-{2-(3,4,5,6-tetra-hydropyrimidin-2-ylamino)ethyloxy}-benzoyl]amino-2-(S)-amino-ethyl-sulfonylamino group. Such compounds provide tumor avidity and imaging ability thus permitting selective and clear tumor imaging.
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK +1

Environment-friendly method for preparing anoxygenic photosynthetic bacterium carotenoids

The invention discloses an environment-friendly method for preparing anoxygenic photosynthetic bacterium carotenoids. The method comprises the steps of collecting wet thalli of anoxygenic photosynthetic bacteria, adding the wet thalli to an alkaline low-concentration ethanol-water solution, selectively extracting and removing bacteriochlorophyll rather than the carotenoids in the wet thalli, and extracting the carotenoids in the wet thalli through absolute ethyl alcohol after removing the bacteriochlorophyll. According to the method, the anoxygenic photosynthetic bacterium carotenoids are extracted according to the ethanol-water process, so that the selectivity is good, the purity of the carotenoids is high, operation is easy, and conditions are mild; no other organic solvents are adopted in the whole process except ethanol and water, so that harmful residues of the organic solvents are reduced, the method is environmentally friendly, operation is easy and convenient, and scale production can be easily achieved.
Owner:HUAQIAO UNIVERSITY
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