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Method for producing sodium copper chlorophyllin through supercritical purification

A sodium copper chlorophyllin and supercritical technology, which is applied in the production of bulk chemicals, chemical instruments and methods, azo dyes, etc., can solve problems such as inability to use supercritical purification, and improve product quality, food and medicine safety, and poor selectivity , highly selective effect

Active Publication Date: 2014-08-06
SHANDONG GUANGTONGBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that supercritical purification cannot be adopted due to the particularity of the molecular structure of chlorophyll and its derivatives, or even if the yield of purification is extremely low, and a method for producing sodium copper chlorophyllin by supercritical purification is provided. The supercritical technology is used to purify copperized chlorophyll, which overcomes the particularity of the molecular structure of chlorophyll derivatives, greatly improves the yield of copperized chlorophyll, and makes the process of producing sodium copper chlorophyllin efficient and environmentally friendly.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A method for producing sodium copper chlorophyllin by supercritical purification, comprising the following steps:

[0034] (1) Saponification: First, 1 part by weight of pasty chlorophyll is dissolved by adding 2 to 6 parts by weight of ethanol solvent, wherein the mass fraction of chlorophyll in the pasty chlorophyll is 12%, and the water content is 23%; Then add the liquid caustic soda that is 0.3~0.8 parts by weight and keep saponification reaction at 60 DEG C for 1 hour;

[0035] (2) Washing: extract and wash the saponified chlorophyll with gasoline for 3 times;

[0036] (3) Copperization: Add 0.1 parts by weight of copper chloride to the saponified chlorophyll after washing and keep it warm at 33°C.

[0037] 3 hours;

[0038] (4) Purification: Use supercritical carbon dioxide to purify and remove impurities for 2 hours at a pressure of 15MPa and a temperature of 36°C;

[0039] (5) Finished product: 0.01 part by weight of sodium hydroxide with a mass fraction of ...

Embodiment 2

[0042] A method for producing sodium copper chlorophyllin by supercritical purification, comprising the following steps:

[0043] (1) Saponification: First, add 4 to 12 parts of methanol solvent to 2 parts by weight of pasty chlorophyll for dissolution, wherein the mass fraction of chlorophyll in pasty chlorophyll is 10%, and the water content is 20%; then add 0.6 ~1.6 parts of liquid caustic soda are kept saponified at 60°C for 1 hour;

[0044] (2) Washing: extract and wash the saponified chlorophyll with gasoline for 3 times;

[0045] (3) Copperization: Add 0.2 parts by weight of copper chloride to the saponified chlorophyll after washing and keep it warm at 48°C.

[0046] 3 hours;

[0047] (4) Purification: Use supercritical carbon dioxide to purify and remove impurities for 2 hours at a pressure of 27MPa and a temperature of 48°C;

[0048] (5) Finished product: 0.02 part by weight of sodium hydroxide with a mass fraction of 97.5% is added to the purified copperized chlo...

Embodiment 3

[0051] A method for producing sodium copper chlorophyllin by supercritical purification, comprising the following steps:

[0052] (1) Saponification: First, add 3.2 to 9.6 parts of acetone solvent to 1.6 parts by weight of pasty chlorophyll for dissolution, wherein the mass fraction of chlorophyll in pasty chlorophyll is 14.3%, and the water content is 23.7%; then add 0.48 ~1.28 parts of liquid caustic soda are incubated and saponified at 60°C for 1 hour;

[0053] (2) Washing: extract and wash the saponified chlorophyll with gasoline for 3 times;

[0054] (3) Copperization: Add 0.16 parts by weight of copper chloride to the saponified chlorophyll after washing and keep it warm at 37°C.

[0055] 3 hours;

[0056] (4) Purification: Use supercritical carbon dioxide to purify and remove impurities for 2 hours at a pressure of 35MPa and a temperature of 65°C;

[0057] (5) Finished product: add 0.016 parts by weight of sodium hydroxide with a mass fraction of 95.9% to the purified ...

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Abstract

The invention belongs to the technical field of production of sodium copper chlorophyllin and in particular relates to a method for producing sodium copper chlorophyllin through supercritical purification. The method for producing sodium copper chlorophyllin through supercritical purification comprises the following steps: (1) saponifying; (2) washing; (3) copperizing; and (4) purifying, namely purifying copperized chlorophyll by adopting supercritical carbon dioxide; and (5) obtaining the finished product. According to the method, the copperized chlorophyll is purified by adopting a supercritical technology, the particularity of a molecular structure of chlorophyll derivatives is overcome, and the yield of the copperized chlorophyll is greatly improved, so that the process of producing the sodium copper chlorophyllin is efficient and friendly to the environment.

Description

technical field [0001] The invention belongs to the technical field of sodium copper chlorophyllin production, and in particular relates to a method for producing sodium copper chlorophyllin through supercritical purification. Background technique [0002] Sodium copper chlorophyllin is a metal porphyrin with high stability. It is a dark green powder. It has been approved by relevant international health organizations for use in food. It is also an edible natural color approved by China. 2011 "Hygienic Standards for the Use of Food Additives", widely used as food additives, cosmetic additives, food colorants, pharmaceuticals and other fields. [0003] Chlorophyll, the raw material for the production of sodium copper chlorophyllin, is easily soluble in organic solvents such as ether and acetone and oils, slightly soluble in alcohol, but insoluble in water. Chlorophyll has certain particularity in molecular structure. Its molecular structure contains a porphine ring formed by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/22C09B61/00
CPCC07D487/22C09B61/00Y02P20/54
Inventor 王占群郑国义孟祥辉谢文科
Owner SHANDONG GUANGTONGBAO PHARMA
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