Purpose of chlorophyll derivative for improving muscle microcirculation disorder
A technology of microcirculation disorder and chlorophyll, which is applied in the field of medicine, can solve the problems of easily causing stomach discomfort, limited users, high drug prices, etc., to prevent and improve muscle microcirculation disorders, and is applicable to a wide range of people. safe effect
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[0051] Preparation of reference solution: Accurately weigh 0.143g of spectrally pure ferric oxide dried at 130°C to constant weight, put it in a beaker, add 5ml of hydrochloric acid solution (1→2) to dissolve, transfer to a 100ml measuring bottle, add Add 4ml of hydrochloric acid solution (1→2), add water to the mark, shake well, accurately measure 10ml, put it in a 100ml measuring bottle, add water to the mark, shake well to get a solution containing about 100μg of Fe per 1ml. Accurately measure 0, 0.2, 0.4, 0.6, 0.8 and 1.0ml of the above solutions respectively, put them in a 10ml measuring bottle, add nitric acid solution (1→500) to the mark, shake well, and you get it.
[0052] Preparation of the test solution: Take an appropriate amount of sample, grind it finely, accurately weigh 10mg, put it in a 50ml beaker, add 1.5ml of nitric acid, 3 drops of perchloric acid, cover with a watch glass, heat to nearly dry at 150-160°C, add Nitric acid (1→2) 2ml, cover with a watch glas...
Embodiment 1
[0086] Example 1 The protective effect of silkworm excrement extract on muscle acute microcirculation disturbance
[0087] According to the above-mentioned method, the iron chlorophyllin sodium weight percentage content is about 37.6%, and other chlorophyll derivatives are calculated as iron chlorophyllin (b) for more than 60.0% of the silkworm excrement, for its effect on rabbit muscle acute microcirculation disorder The role of the test, the results are as follows.
[0088] Table 1 The effect of silkworm excrement extract on the change rate of rabbit muscle microcirculation ( n=6)
[0089]
[0090] Note: Compared with the negative control group: *: P<0.05, **: P<0.01
[0091] Table 1 shows that, compared with the negative control group, the change rate of blood perfusion (PU) in the high and middle dose groups of silkworm excrement extract was significantly reduced (P<0.01); The rate of change was significantly reduced (P<0.01). The change rate of blood cell velocity...
Embodiment 2
[0092] Example 2 The protective effect of silkworm excrement extract on acute microcirculation disturbance
[0093] The experiment of Example 1 was repeated, except that the iron chlorophyllin sodium sodium iron chlorophyllate content was about 29.1% by weight, and other chlorophyll derivatives were tested with iron chlorophyllin (b) as the silkworm excrement above 60.0%. The results showed that blood perfusion (PU), blood cell aggregation (CMBC) and movement blood cell velocity (V) rate of change in the high, middle and low dose groups all decreased, indicating that the muscle microcirculation disturbance of the tested rabbits was improved.
[0094] It can be known from the above examples that sodium ferric chlorophyllin and chlorophyll derivatives containing sodium ferric chlorophyllin (such as silkworm excrement) can effectively improve or regulate blood perfusion, concentration of moving blood cells and speed of moving blood cells, thereby improving muscle Acute microcircula...
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