Method for extracting chlorophyll and preparing sodium ferrous chlorophyll from silkworm excrement

Abstract

The invention discloses a method for extracting chlorophyll and preparing sodium ferrous chlorophyll from silkworm excrement, belonging to the field of traditional Chinese medicine. In the method, high-purity sodium ferrous chlorophyll and chlorophyll derivatives are prepared from the silkworm excrement by using an ultramicro smash and extraction technology under the conditions of medium-concentration ethanol and temperature control according to the process steps of extraction, saponification, purification, ferrugination and alkalization, thereby improving the production efficiency. The effect of the method is obviously superior to that of the prior art.

Description

A method for extracting chlorophyll from silkworm excrement and preparing sodium iron chlorophyllin technical field The invention relates to a method for extracting chlorophyll from traditional Chinese medicine silkworm excrement and preparing sodium iron chlorophyllin, which belongs to the field of traditional Chinese medicines. Background technique Chlorophyll is a natural pigment allowed to be used in my country and most countries. Its derivatives have various biological activities in medicine, such as promoting wound healing, anti-ulcer, anti-tumor, anti-microbial, anti-cancer, liver protection, and anti-anemia. The basic structure of chlorophyll is very similar to the structure of heme in the blood of humans and most animals, both of which are tetrapyrrole metal compounds. The main difference is that the central atom of chlorophyll is magnesium, while the central atom of heme is iron. Ferrous sodium chlorophyllin (also known as ferric sodium chlorophyllin, ferric chlo...

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Problems solved by technology

In order to ensure sufficient extraction, this type of method generally requires soaking overnight, and then reflux extraction for several hours. , it is very easy to be destroyed when it is above 80°C, so when it is extracted by heating and reflux, especially when ethanol with a higher boiling point is used as a solvent (considering economical and environmental protection), chlorophyll is often destroyed to a certain extent

In the patent authorization document CN100390176C, before extracting chlorophyll from silkworm excrement, a microwave pretreatment process is added to destroy tissue cells and reduce the resistance of chlorophyll to permeate cells and dissolve into organic solvents, thereby improving extraction efficiency. However, this technology has an obvious The disadvantage is that the temperature of the microwave treatment material is extremely high, even if the processing time is 30-90 seconds, the high temperature will destroy part of the chlorophyll, thus greatly reducing the extraction rate

The chlorophyll in the prior art is obtained by direct extraction of organic solvents, which has many defects such as slow speed, long time consumption, many impurities in the extract, low chlorophyll purity, large consumption of organic solvents in the later treatment process, and high energy consumption, which is not conducive to industrialization. Production

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