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57 results about "Tetrapyrrole" patented technology

Tetrapyrroles are a class of chemical compounds that contain four pyrrole or pyrrole-like rings. The pyrrole/pyrrole derivatives are linked by (=(CH)- or -CH₂- units), in either a linear or a cyclic fashion. Pyrroles are a five-atom ring with four carbon atoms and one nitrogen atom. Tetrapyrroles are common cofactors in biochemistry and their biosynthesis and degradation feature prominently in the chemistry of life.

Process for the carbonylation of epoxides

The present invention pertains to a process for the carbonylation of an epoxide by reacting it with carbon monoxide in the presence of a catalyst system containing two components, wherein the first component is a source of one or more metals selected from the group consisting of cobalt, ruthenium and rhodium, and the second component is a coordination complex of a tetrapyrrole compound with one or more of the metals belonging to the group consisting of groups IIIA and IIIB of the periodic system, lanthanides and actinides. The present invention also pertains a process for the preparation of a catalyst system.
Owner:SHELL OIL CO

Porphyrins with virucidal activity

InactiveUS20050090428A1Effectively prevent infectionBiocidePeptide/protein ingredientsDiseaseMedicine
Compositions and methods of using thereof for the prevention of sexually transmitted diseases resulting from infection with one or more of viral pathogens have been developed. The compositions contain one or more porphyrins, tetrapyrrole macrocycle compounds with bridges of one carbon joining the pyrroles. In a preferred embodiment, the compositions are administered in a formulation suitable for administration to a mucosal surface.
Owner:EMORY UNIVERSITY +1

Photochemotherapeutical obstruction of newly-formed blood vessels

A photosensitive tetrapyrrole derivative having formula (I)where n stands for 1 or 2 or a pharmaceutically acceptable salt thereof is useful as an effective ingredient in an obstruent composition for photochemotherapeutically obstructing neovascular vessels. The photosensitive tetrapyrroles of the formula (I) may be administered in a photochemotherapeutic method for obstructing neovascular vessels, particularly choroidal and retinal neovascularizations.
Owner:MEIJI SEIKA KAISHA LTD

Method of disrupting heme transport in nematodes and of modelling and evaluating eukaryotic heme transport

A method for treating helminthic infections in a mammal or plant which entails administering one or more compounds which are metal-ligand chelate compounds containing a metal and a tetrapyrrole compound or a porphyrin compound, to mammal or plant in need thereof.
Owner:UNIV OF MARYLAND

Water-soluble mono-PEGylated tetrapyrrole derivatives for photodynamic therapy and method of production

Water-soluble mono-PEGylated tetrapyrrole derivatives are disclosed, having a formula given by formula 1, 2, or 3 in the specification. A method to produce the above water-soluble mono-PEGylated compounds is also disclosed, comprising an interaction of a tetrapyrrole with an aminopolyethylene glycol containing a functionalized terminal fragment, as well as their use as photosensitizers in photodynamic therapy.
Owner:BIOLITEC UNTERNEHMENSBETEILLIGUNGS II AG

Fluorescent phycocyanin and fluorescent phycoerythrin and their application

The present invention discloses a fluorescent phycocyanin and a fluorescent phycaerythrin. The phycocyanin and the phycaerythrin have molecular structure connected to open-chained linear tetraphyrrolyl compound as carrier protein and chromophore via thioether bond, are extracted from algae and can emit strong fluorescence after being excitation of light with proper wavelength. The present invention also discloses serial uses of the phycocyanin and the phycaerythrin in fluorescent detection and immunological analysis, in preparing anticarcinogen medicine and food, in preparing medicine and food for resisting irradiation, strengthening immune, in preparing photon switch, and in preparing food and cosmetic additive.
Owner:刘维国

Adduct of fluorescent dye and tumor avid tetrapyrrole

A compound having preferential localization in tumor tissue relative to normal tissue, a preferential electromagnetic absorption at a wavelength between about 660 and 900 nm, and a fluorescence at a wavelength shifted from the preferential absorption by at least +30 nm and preferably at least +50 nm. The compound further preferably destroys tumor tissue in which it is absorbed when exposed to light at its preferential absorption wavelength. In a preferred embodiment of the invention, the compound is a conjugate of a tumor avid tetrapyrrole compound with a fluorescent dye, and more preferably the fluorescent dye is an indocyanine dye such as indocyanine green. The tumor avid tetrapyrrole compound is preferably a porphyrin derivative selected from the group consisting of chlorins, bacteriochlorins, purpurins and derivatives thereof.
Owner:HEALTH RES INC

Process for the carbonylation of epoxides

The present invention relates to a process for the carbonylation of epoxides by reacting epoxides with carbon monoxide in the presence of a two-component catalyst system, wherein the first component is one or more of cobalt, ruthenium and rhodium. A variety of metal sources, the second component is a coordination complex of tetrapyrrole compound and one or more metals belonging to IIIA and IIIB groups, lanthanides and actinides in the periodic system. The invention also relates to a process for the preparation of the catalyst system and the use of the catalyst system in the carbonylation of epoxides.
Owner:SHELL INT RES MAATSCHAPPIJ BV

Zeolite Including Oxygen-Activated Metal Complex And Gas Decomposition Agent

Provided are zeolite comprising a metal and an oxygen-activated metal complex, wherein the above oxygen-activated metal complex is included within a unit cell comprised in the above zeolite as well as a gas decomposition agent comprised of the above zeolite. Examples of the above oxygen-activated metal complex are phthalocyanine metal complex, a bis(salicylidene)-o-phenylenediamidinato metal complex and a metal complex comprising a cyclic tetrapyrrole compound as a ligand. Examples of metal of the above oxygen-activated metal complex are silver, copper, zinc, platinum, palladium, cobalt, iron, manganese, ruthenium and the like. The above gas decomposition agent has an effect capable of continuously decomposing gases that are harmful to the health or felt unpleasant by human.
Owner:SINANEN ZEOMIC CO LTD +1

Light-emitting material and preparation method thereof

The invention provides a light-emitting material and a preparation method thereof. The light-emitting material includes an organic complex; the organic complex is composed of tetrapyrrole macrocyclicligand A, rare-earth ion Ln and deuterated or halogenated tripodal ligand B. The organic complex gains increased external quantum dot efficiency and improved light emergence stability; near-infrared light (800-1600 nm) can be emitted efficiently under purple and blue light excitation; external quantum efficiency is high, light emission life is long, wherein the external quantum efficiency may reach 0.63 and above. In addition, emitting peak position and width can be regulated and controlled through different rare-earth ion or rear-earth ion combinations so as to improve the light-emitting performance of the light-emitting material. The light-emitting material has a promising application prospect in fiber-optic communication, biological imaging, signal conversion and amplification and component analysis fields.
Owner:PEKING UNIV +1

Synthetic route to ABCD-porphyrins

A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under basic conditions to produce the metalloporphyrin. Products produced by such methods and intermediates useful for carrying out such methods are also described.
Owner:NORTH CAROLINA STATE UNIV

Amphiphilic dye-coated inorganic nanoparticle clusters

The invention relates to amphiphilic dye-coated inorganic nanoparticle clusters and uses thereof. Specifically, the invention relates to cyanine and / or cyclic tetrapyrrole dye-coated metallic nanoparticle clusters for use in medical imaging and treatments.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA

Rare earth complex with near infrared pH intensity and life response

The invention discloses a rare earth complex capable of performing intensity and life response on pH in a near infrared area (800-1600 nm) as well as preparation and application thereof. The compoundcomprises a tetrafluoropyrrole organic ligand, rare earth ions and an axial ligand. The compounds have excellent biocompatibility; the light intensity and the life are obviously changed along with thechange of pH; and the compounds are a potential living body intensity and life imaging reagent and a pH detection medicine.
Owner:PEKING UNIV

Cell factories for improved production of compounds and proteins dependent on iron sulfur clusters

PendingUS20220127311A1Increased apoprotein : holoproteinHigh expressionDepsipeptidesOxidoreductasesCell factoryPyrroloquinoline quinone
The invention relates to a genetically modified prokaryotic cell capable of improved iron-sulfur cluster delivery, characterized by a modified gene encoding a mutant Iron Sulfur Cluster Regulator (IscR) and one or more transgenes or upregulated endogenous genes encoding iron-sulfur (Fe—S) cluster polypeptides or proteins that catalyze complex radical-mediated molecular rearrangements, electron transfer, radical or non-redox reactions, sulfur donation or perform regulatory functions. The prokaryotic cells are characterized by enhanced activity of these iron-sulfur (Fe—S) cluster polypeptides, enhancing their respective functional capacity, and facilitating enhanced yields of compounds in free and protein-bound forms, including heme, hemoproteins, tetrapyrroles, B vitamins, amino acids, δ-aminolevulinic acid, biofuels, isoprenoids, pyrroloquinoline quinone, ammonia, indigo, or their precursors, whose biosynthesis depends on their activity. The invention further relates to a method for producing said compounds or their precursors using the genetically modified prokaryotic cell of the invention, and the use of the genetically modified prokaryotic cell.
Owner:BIOSYNTIA APS

Antioxidants

This invention features a method for eliciting an antioxidative effect. The method includes administering to a subject (e.g., an animal or human) in need thereof an effective amount of a tetrapyrrole compound of formula (I): Each of R, R, R<c>, R<d>, R<e>, R<f>, R<g>, and R<h>, independently, is H or alkyl; R1 is alkyl or CHO; R2 is alkyl; R3 and R4 taken together are part of a cyclyl or heterocyclyl ring, and R5 is (CH2)mCOOR, in which R is H, and m is 1, 2, or 3; or R3 is (CH2), COOR', C(O)(CH2)nCOOR', CH(OH)(CH2)nCOOR', and R4 and R5 taken together are part of a cyclyl or heterocyclyl ring, in which R' is H or alkyl, and n is 0, 1, 2, or 3; and R6 is alkenyl or CHO; the tetrapyrrole compound optionally being chelated with Mg<2+>, Mn<2+>, Cu<2+>, Fe<2+>, Co<2+>, Ni<2+>, or Zn<2+> through the nitrogen atoms on the four pyrrole rings.
Owner:ACAD SINIC

Near infrared (NIR) photodynamic therapy (PDT) in combination with chemotherapy

Methods for treatment of cancer are provided. The methods are based on the use of both NIR photosensitizer(s) and chemotherapy agent(s). The NIR photosensitizers have a tetrapyrrolic core or reduced tetrapyrrolic core. Also provided are pharmaceutical compositions comprising NIR photosensitizer(s) and chemotherapy agent(s). Also provided are kits comprising NIR photosensitizer(s) and chemotherapy agent(s) and instructions for their use.
Owner:HEALTH RES INC

Functional molecular element, method for producing functional molecular element, and functional molecular device

Disclosed herein are a functional molecular element with a reduced contact resistance between the constituting molecule and the electrode, a method for production thereof, and a functional molecular device. The method consists of the following steps. A closely adhering molecular monolayer is formed on the surface of the electrodes from a pai-electron conjugated molecule (one species of linear tetrapyrrole) composed of the porphyrin-like nearly discoid skeleton and the flexible side chains (alkyl chains). A ¿ñ-electron conjugated molecule of the same species as the one or different species from the one is piled on the monolayer by pai-pai stacking to form the array structure. As the result of the foregoing steps, the pai-pailectron conjugated molecule constituting the first molecular layer of the array structure takes on such a configuration that the flexible side chains adsorb to the surface of the electrode and the discoid skeleton orients parallel to and adheres to the surface of the electrode. The second and subsequent molecular layers constituting the array structure have their piling direction controlled by the pai-pai mutual action.
Owner:SONY CORP

Photodynamic therapy using photosensitizing agent or 5-aminolevulinic acid

It is to provide photodynamic therapy (PDT) and photodynamic diagnosis (PDD) which are suitable for the diagnosis and therapy of a part requiring a certain degree of deep penetration, such as subcutaneous cancer and lymph nodes surrounded by blood vessels and fat. This is solved by performing PDT and PDD targeting cancer by administering a composition comprising a photosensitizing agent such as a tetrapyrrole-based compound (photofrin, protoporphyrin IX, etc.) or ALAs such as 5-aminolevulinic acid (ALA), ALA methyl ester, ALA ethyl ester, ALA propyl ester, ALA butyl ester, ALA pentyl ester, or a hydrochloride, phosphate, or sulfate thereof followed by irradiation with excitation light at a wavelength of 480 to 580 nm.
Owner:SBI PHARMA CO LTD

Functional molecular element, process for producing the same and functional molecular device

A functional molecular element having a structure in which the contact resistance at the interface between a constituting molecule and an electrode can be reduced, the functional molecular element having a specific conductivity, a process for producing the same, and a functional molecular device, are provided. A π-electron conjugated molecule 1, which is one species of linear tetrapyrrole having a substantially disk-shaped central skeleton moiety 2 and a flexible side chain moiety 3 composed of an alkyl group, is dissolved in 4-pentyl-4′-cyanobiphenyl or tetrahydrofuran, and the concentration is adjusted to an appropriate level. This solution is applied to electrodes 5 and 6, and the solvent is evaporated, whereby an array structure 4 of the π-electron conjugated molecules 1 is self-organizingly formed. An adsorbate molecule 9 in the first layer of the array structure 4 is fixed in such a manner that its side chain moiety 3 is adsorbed on a surface of the electrode 5 or 6 and a substantial disk plane of the skeleton moiety 2 is parallel to and adhered to the surface of the electrode 5 or 6. The stacking direction of the π-electron conjugated molecules 1 in the second and subsequent layers of the array structure 4 is controlled by the π-π interaction between the substantially disk-shaped central skeleton moieties 2.
Owner:SONY CORP

Method of disrupting heme transport in nematodes and of modelling and evaluating eukaryotic heme transport

A method for treating helminthic infections in a mammal or plant which entails administering one or more compounds which are metal-ligand chelate compounds containing a metal and a tetrapyrrole compound or a porphyrin compound, to mammal or plant in need thereof.
Owner:UNIV OF MARYLAND

Novel tetrapyrrole derivative and application thereof

The invention relates to a novel intermediate di(disubstituted) phenyl dihalogenated porphin derivative which is stable in performance, good in hydrophilicity and not prone to aggregation and an application thereof. The compound has the following structures (I) and (II), wherein X is Cl, Br or I; A and Y are the same or different and are independently CH2 or O; R1 and R2 are different, R3 and R4 are the same or different, at least one of R3 and R4 contains a polar group, and R3 and R4 are independently alkyl groups, alkyl groups containing N or O atoms, alkyl groups containing carbonyl groups or alkyl groups containing amido bonds or alkyl carboxylic acid, alkyl alcohol, alkyl carboxylic acid containing N or O atoms, alkyl alcohol containing N or O atoms, alkyl carboxylic acid containing carbonyl groups, alkyl alcohol containing carbonyl groups, alkyl carboxylic acid containing amido bonds, and alkyl carboxylic acid containing carbonyl groups and amido bonds at the same time. The prepared intermediate dihalogenated diphenyl porphin photosensitizer has remarkable photodynamic activity, and can be used as a drug for photodynamic diagnosis and treatment of diseases such as tumors, retina macular degeneration, actinic keratosis, nevus flammeus and condyloma acuminata.
Owner:SHANGHAI XIANHUI MEDICAL TECH

Hypochlorous acid disinfectant and preparation method thereof

In order to overcome the defects of poor stability, short shelf life and the like of a hypochlorous acid disinfectant in the prior art, the invention provides a stable hypochlorous acid disinfectant which comprises a mixture of the following components: a hypochlorite aqueous solution, a pH regulator, a stabilizer and a diluent, wherein the stabilizer is water-soluble porphyrin, porphyrin has a tetrapyrrole conjugated large pi rigid plane and a plurality of conjugated delocalized pi electrons, and can form ppi conjugation with Cl in hypochlorous acid, so that the hypochlorous acid structure ismore stable, the stability of the hypochlorous acid disinfectant is improved, the shelf life of the hypochlorous acid disinfectant is prolonged, the pH regulator is an acidic regulator, and the diluent is a buffer solution of conjugated acid-base pairs. The invention also provides a preparation method of the hypochlorous acid disinfectant and application of the hypochlorous acid disinfectant in the aspects of instrument disinfection, object surface disinfection, skin disinfection and air disinfection.
Owner:DONGGUAN DONGYANG SOLAR SCI RES & DEV CO LTD

Method for preparing tetrapyrrole compounds and tetrapyrrole compounds

A tetrapyrrole compound is prepared by cultivating bacterial cells of Escherichia coli, which cannot express the gene ypjD (b2611) due to the variation thereof, in a culture medium and obtaining the resulting tetrapyrrole compound having a porphyrin ring structure from the culture medium.
Owner:FUKUTOME HIROFUMI

Pharmaceutical Composition for Photodynamic Therapy and a Method for Treating Oncological Diseases by Using Said Composition

InactiveUS20090012008A1Broaden irradiation spectrumAdd depthBiocideOrganic active ingredientsDiseaseDipeptide
The present invention relates to the field of medicine, particularly to oncology and provides a pharmaceutical composition intended for the photodynamic therapy of malignant tumors, comprising a therapeutically effective amount of at least one of derivatives of fullerene C60 selected from the group consisting of a compound in which a fullerene C60 molecule covalently binds to one molecule of an amino acid or a dipeptide, or its pharmaceutically acceptable derivative, or a complex of a compound with biocompatible synthetic polymers or biopolymers and tetrapyrroles, or a conjugate of a compound with an amino compound. Said compounds after accumulation in cells and photoirradiation transform molecular oxygen into singlet oxygen, generate free radicals, and also trigger biological processes inhibiting the vital activity of tumor cells. The present invention also relates to a method of photodynamic therapy of malignant tumors, in which the pharmaceutical composition of the present invention is used as the photosensitizer.
Owner:VLADIMIR PETROVICH LAPTEV +1

B ring reduced-d ring oxidized tetrapyrollic photosensitizers for photodynamic therapy and tumor imaging

Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl3.6H2O to oxidize the D ring and separating the resulting organic layer and drying.
Owner:HEALTH RES INC

Application of BUIPTP (binuclear uranyl-isophthalaldehyde-tetrapyrrole) to ATP (Adenosine Triphosphate) analysis

The invention discloses application of a BUIPTP (binuclear uranyl-isophthalaldehyde-tetrapyrrole) to ATP (Adenosine Triphosphate) analysis and belongs to the technical field of biochemical analysis detection method. The application comprises the following steps: determining optimal conditions for detecting ATP; preparing a BUIPTP detection base solution; drawing a standard curve of determined ATP;analyzing the content of the ATP in a sample: weighing a sample to be detected, which contains the ATP; adding water for dissolving or diluting; adding a Tris-HCl buffering solution; while stirring,dropwise adding the BUIPTP detection base solution into the solution; determining second-grade scattering spectral intensity at a part with optimal wavelength. By adopting a detection method providedby the invention, the deviation between the detected ATP concentration and objective concentration is less than 2.5 percent; the detection method provided by the invention has very high accuracy; whenthe concentration of the ATP is lower than 0.75nmol.L<-1>, the ATP still can be detected; the detection method has a good detection effect in a range of 2.5 to 500nmol.L<-1>.
Owner:NANHUA UNIV

Functional molecular element, process for producing the same and functional molecular device

It is intended to provide a functional molecular element having a specific conductivity, which is a functional molecular element having a structure enabling reduction in the contact resistance at the interface between a constituting molecule and an electrode, a process for producing the same and a functional moleucalr device. A n-electron conjugated molecule (1), which is one species of linear tetrapyrrole having an almost disc-shaped central skeleton (2) and a flexible side chain (3) consisting of an alkyl group, is dissolved in 4-pentyl-4'-cyanobiphenyl or tetrahydrofuran and the concentration is adjusted to an appropriate level. This solution is adhered to electrodes (5) and (6) and the solvent is evaporated. Thus, an array structure (4) of the n-electron conjugated molecule (1) is self-organizingly formed. An adsorbed molecule (9) in the first layer of the array structure (4) is fixed in such a manner that its side chain (3) is adsorbed on the surface of the electrode (5) or (6) while the almost disc-shaped face of the sekeleton (2) is adhered in parallel to the surface of the electrode (5) or (6). The stacking direction of the n-electron conjugated molecule (1) in the second layer and thereafter of the array structure (4) is regulated by the n-n interaction between the disc-shaped face of the sekeletons (2).
Owner:SONY CORP

Novel tetrapyrrole compound and application thereof

PendingCN113754672ASignificant photodynamic activityLow phototoxic side effectsSenses disorderOrganic chemistrySide effectMacula lutea degeneration
The invention relates to a novel water-soluble intermediate di (disubstituted amino) phenyl porphin tetrapyrrole compound which is good in hydrophilicity, easy to prepare into an injection and simple and feasible in preparation process, and a preparation method of the tetrapyrrole compound shown in the description, wherein X is H, Cl, Br, or I; R is a meta-position or para-position group, and R is -N (R1) 2; R1 is -(CH2)nCOOH, and n is equal to 1-6; and R2 is 2H or Zn. The invention relates to the field of photosensitive drugs and photodynamic therapy, in particular to a novel intermediate di (disubstituted amino) phenyl porphin tetrapyrrole compound which is good in hydrophilicity and easy to prepare into injection, a preparation method of the intermediate di (disubstituted amino) phenyl porphin tetrapyrrole compound and application of the intermediate di (disubstituted amino) phenyl porphin tetrapyrrole compound in the field of medicine. The intermediate di (disubstituted amino) phenyl porphin photosensitizer prepared by the invention has remarkable photodynamic activity and low skin light toxic and side effects, and can be used as a drug for photodynamic diagnosis and treatment of diseases such as tumors, retina macular degeneration, actinic keratosis, nevus flammeus and condyloma acuminata.
Owner:SHANGHAI XIANHUI MEDICAL TECH

Adduct of fluorescent dye and tumor avid tetrapyrrole

A compound having preferential localization in tumor tissue relative to normal tissue, a preferential electromagnetic absorption at a wavelength between about 660 and 900 nm, and a fluorescence at a wavelength shifted from the preferential absorption by at least +30 nm and preferably at least +50 nm. The compound further preferably destroys tumor tissue in which it is absorbed when exposed to light at its preferential absorption wavelength. In a preferred embodiment of the invention, the compound is a conjugate of a tumor avid tetrapyrrole compound with a fluorescent dye, and more preferably the fluorescent dye is an indocyanine dye such as indocyanine green. The tumor avid tetrapyrrole compound is preferably a porphyrin derivative selected from the group consisting of chlorins, bacteriochlorins, purpurins and derivatives thereof.
Owner:HEALTH RES INC
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