Rare earth complex with near infrared pH intensity and life response

A technology of rare earth complexes and rare earth ions, which can be applied to organic compounds of group 3/13 without C-metal bonds, compounds containing elements of group 3/13 of the periodic table, organic chemistry, etc., which can solve the problem of short life and limited applications , Low luminous quantum yield and other issues, to achieve the effect of near-infrared intensity imaging and lifetime imaging

Active Publication Date: 2018-08-21
PEKING UNIV
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reported dyes in the second near-infrared region have only realized the research of fluorescence intensity imaging, and the luminescence quantum yield is low and the lifetime is short, which limits their applic...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Rare earth complex with near infrared pH intensity and life response
  • Rare earth complex with near infrared pH intensity and life response
  • Rare earth complex with near infrared pH intensity and life response

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The synthesis of embodiment 1 complex 1:

[0038]

[0039] The first intermediate product was obtained by mixing the corresponding fluorinated tetrapyrrole ligand and ytterbium acetylacetonate salt in trichlorobenzene and reacting at 200° C. under nitrogen atmosphere. The resulting first intermediate and the corresponding deuterated The tripod ligand was reacted in chloroform to obtain a second intermediate product. Then react the second intermediate product in sulfuric acid to obtain complex 1. For the location of the main emission peak, see figure 1 : 920nm, 950nm, 980nm, 1000nm, 1020nm, 1050nm; main excitation peak position: 418 nm, 560nm, 620nm; lifetime: about 170μs.

Embodiment 2

[0040] The synthesis of embodiment 2 complex 2:

[0041]

[0042] The first intermediate product was obtained by mixing the corresponding fluorinated tetrapyrrole ligand and ytterbium acetylacetonate salt in trichlorobenzene and reacting at 200° C. under nitrogen atmosphere. The resulting first intermediate and the corresponding deuterated The tripod ligand was reacted in chloroform to obtain a second intermediate product. Then the second intermediate product was hydrolyzed by potassium hydroxide in methanol and tetrahydrofuran to obtain complex 2. Main emission peak position: 920nm, 950nm, 980nm, 1000nm, 1020nm, 1050nm; main excitation peak position: 416nm, 546nm, 592nm; lifetime: about 150μs.

Embodiment 3

[0043] The synthesis of embodiment 3 complex 3:

[0044]

[0045] The first intermediate product was obtained by mixing the corresponding fluorinated tetrapyrrole ligand and ytterbium acetylacetonate salt in trichlorobenzene and reacting at 200° C. under nitrogen atmosphere. The resulting first intermediate and the corresponding deuterated The tripod ligand was reacted in chloroform to obtain a second intermediate product. Then react the second intermediate product in (trimethylsilyl)phosphite to obtain complex 3. Main emission peak position: 920nm, 950nm, 980nm, 1000nm, 1020nm, 1050nm Excitation main peak position: 416nm, 546nm, 592nm; lifetime: about 140μs.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a rare earth complex capable of performing intensity and life response on pH in a near infrared area (800-1600 nm) as well as preparation and application thereof. The compoundcomprises a tetrafluoropyrrole organic ligand, rare earth ions and an axial ligand. The compounds have excellent biocompatibility; the light intensity and the life are obviously changed along with thechange of pH; and the compounds are a potential living body intensity and life imaging reagent and a pH detection medicine.

Description

technical field [0001] The invention relates to the field of biological imaging and probes, in particular to a rare earth complex that responds to pH in the second near-infrared region and its preparation method and biological application, which can effectively realize near-infrared intensity and lifetime imaging, and to Effective detection of intracellular pH changes. Background technique [0002] Compared with the traditional dyes in the first near-infrared region (700-900nm), dyes in the second near-infrared region (900-1200nm) can achieve deeper tissue imaging (Cheng Z, et al.Chem.Soc.Rev., 2018, DOI: 10.1039 / c8cs00234g; Dai H, et al. Nat. Biomed. Eng., 2017, 1, 0010). However, the reported dyes in the second near-infrared region have only realized the research of fluorescence intensity imaging, and the luminescence quantum yield is low and the lifetime is short, which limits their application as near-infrared biological probes (Wan H, Yue J, Zhu S, et al. Nat. Commun....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07F19/00C07F5/00C09K11/06G01N21/64
CPCC07F5/003C07F17/02C09K11/06C09K2211/182C09K2211/187G01N21/6486
Inventor 张俊龙宁莹莹
Owner PEKING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap