The invention relates to a method for grouting sealing of a gap between a steel door frame of a protective sealed door and a wall, which belongs to the technical field of architectural construction. The method comprises the following construction steps of: 1) drilling and cleaning holes, namely drilling the holes on a concrete surface nearby the gap upwards or downwards by aiming at the direction of the gap, and cleaning dust in the holes after drilling; 2) embedding needle heads, namely embedding grouting needle heads through tool fastening; 3) grouting: a, mixing a water-soluble polyurethane chemical grouting material with an oil-soluble polyurethane chemical grouting material according to a weight proportion of 1:1 to prepare serous fluid; and b, starting grouting the serous fluid from a first needle head, immediately stopping the grouting when the serous fluid emerges from an adjacent needle head, continuously grouting the serous fluid from a second needle head, and performing the grouting forwards in turn; and 4) processing needle holes, namely after the serous fluid is coagulated, removing the grouting needle heads, and sealing the holes. The method has the advantages of simple process, convenient construction, reliable performance, corrosion resistance, no generation of mildews, high expansion efficiency, obvious construction effect and the like.