40 results about "Cells precursor" patented technology

The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).

A method of producing pancreatic cells or pancreatic cell precursors expressing at least 5% PDX1 / NKX6.1 double positive, comprising exposing definitive endoderm cells to an effective amount of one or more small molecules, to differentiate the human definitive endoderm cells into the pancreatic cells or pancreatic cell precursors. The present invention also relates to pancreatic endoderm cells produced by said methods and uses of said pancreatic endoderm cells.

A cell culture system including a silk fibroid scaffold, culture media, and pancreatic cells. The pancreatic cells grown in the tissue culture system have physiological and morphological features like those of in vivo pancreatic cells. The cell culture system can be used to produce a pancreatic tissue-specific extracellular matrix capable of inducing differentiation of pancreatic cell precursors into pancreatic cells.

A method for testing a precursor of a secondary cell with high reliability and high efficiency to judge the precursor to be acceptable or defective. The current flowing when a test voltage is applied between a pair of electrodes is measured before an electrolyte is placed between the electrodes. If a current the current value of which exceeds a predetermined reference current value (13) is detected during the time from the start of application of a voltage to a normal secondary cell precursor until the current becomes constant, the precursor is determined to be defective.

The invention discloses a spherical hollow porous MnO / C composite material and an application thereof. The spherical hollow porous MnO / C composite material is obtained by the following steps: with natural algae cells as a carbon source and a template and with a mixed solution of potassium permanganate and sodium sulfate as a chemical plating solution, uniformly adsorbing manganese dioxide on the surfaces of the natural algae cells through an impregnation method, so as to obtain a natural algae cell precursor adsorbed with the manganese dioxide; adding a solution containing a reducing carbon source to the natural algae cell precursor adsorbed with the manganese dioxide; and reacting the solution containing the reducing carbon source with the natural algae cell precursor adsorbed with the manganese dioxide for 1-6 hours under the protection of chemical inert gases at 400-700 DEG C, so as to obtain the spherical hollow porous MnO / C composite material. According to the invention, the obtained spherical hollow porous MnO / C composite material has the advantages of excellent rate capability and excellent cycling stability and can be widely applied to the fields of high performance lithium ion batteries and the like as a lithium ion battery cathode material.

The invention discloses a method for preparing a tumor-specific DC vaccine by applying mononuclear cells of umbilical cord blood. The method comprises (1) a step of preparing autologous tumor-related holoantigen; (2) a step of obtaining the umbilical cord blood; (3) a step of obtaining the mononuclear cells derived from the umbilical cord blood; (4) a step of performing induction culture for a precursor DC of the mononuclear cells derived from the umbilical cord blood; (5) a step of performing amplification and culture of an immature DC; and (6) a step of preparing the DC vaccine.

The invention relates to a method, a reagent and a kit for detecting minimal residual disease. The present invention relates to the field of minimal residual disease (MRD) diagnostics, which is increasingly used to evaluate the efficacy of treatment in patients with hematological malignancies, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic Cellular Leukemia (B‑CLL) and Multiple Myeloma (MM). The unique reagent composition offered features carefully selected and thoroughly tested antibody combinations that achieve at least 10 for ≥8 color flow cytometry staining and for 10 and 12 color flow cytometry ‑4 even as low as 10 ‑5 sensitivity. The invention also provides diagnostic kits and methods for detecting MRD.

The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).

The present invention relates to any isolated or synthetic compound, in particular a compound of general formula (I), which is capable of modulating the cellular specialization of neural stem cells, favoring the differentiation and subsequent survival of neurons and glial cells during differentiation. and differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the compounds according to the invention are able to reduce inflammatory substances in diseases affecting the nervous system, in particular by reducing the activation of microglia and / or astrocytes and / or by reducing reactive gliosis. The present invention also relates to a method for preparing the compound and the use of the compound in the preparation of a pharmaceutical composition for the prevention or treatment of diseases affecting the nervous system. More specifically, the compounds of the present invention have the following general formula (I).

The invention relates to a method for inducing immunological tolerance, in particular transplantation tolerance, by administering a G-CSF derivative or biologically active fragment, homolog, or variant thereof, in particular peg-G-CSF, to a donor cell or a transplantation donor. The invention also relates to expanding and stimulating selected donor cells by administering a G-CSF derivative, preferably peg-G-CSF. The donor cells are preferably granulocyte-monocyte precursor cells and IL-10 secreting T cells.

The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).

The present invention relates to isolated human cells that are precursors of endothelial cells other than embryonic stem cells, to isolated murine cells that are precursors of endothelial cells, and to methods using same. In particular, the present invention relates to established cell lines of isolated human cells that are precursors of endothelial cells other than embryonic stem cells and established cell lines of isolated murine cells that are precursors of endothelial cells. The present invention can be used in particular in the medical and / or veterinary fields, in particular in the field of therapeutics and / or in the field of studies of cellular mechanisms.

A first paste for a first electrode layer and a second paste for a second electrode layer are printed on a fired solid electrolyte by screen printing, etc. to form electrode patterns for forming the first electrode layer and the second electrode layer. The first and second pastes can be prepared by dissolving a binder in an organic solvent, adding an appropriate amount of the obtained solution to powders of an electrode active substance material and a solid electrolyte material, and kneading the resultant mixture. The first and second pastes are applied to the fired solid electrolyte to form a cell precursor, the cell precursor is placed in a hot press mold subjected to a thermal treatment while pressing from above by a punch, whereby the first and second electrode layer are formed from the first and second pastes.

The invention relates to a method of assessing the viability of a thawed cell wherein the cell is a gamete, an embryo, a karyoplast, a putative stem cell population, a stem cell precursor population or a stem cell population. The method includes incubating the thawed cell in a culture medium including a plurality of amino acids and determining the change in concentration in the medium of at least one amino acid.

The present invention relates to isolated human cells that are precursors of endothelial cells other than embryonic stem cells, to isolated murine cells that are precursors of endothelial cells, and to methods using same, In particular, the present invention relates to established cell lines of isolated human cells that are precursors of endothelial cells other than embryonic stem cells and established cell lines of isolated murine cells that are precursors of endothelial cells. The present invention can be used in particular in the medical and / or veterinary fields, in particular in the field of therapeutics and / or in the field of studies of cellular mechanisms.