The invention provides an
antibody composition, and applications thereof in Lymphoplasmacytic
Lymphoma minimal residual detection. Based on a plurality of years of clinical practice and research, twotubes eight colors 16
antibody compositions are obtained via screening, and high efficiency high sensitivity distinguishing identifying of
abnormal cell population is realized; on the above base, FITC, PE, Percp5.5, Pe-cy7, APC, AF750, BV421, and V500 fluorescent labels are selected preferably, and results of eight kinds of antibodies are obtained in detection of one flow tube in an eight
color flow cytometry single tube. In addition, a corresponding
analysis method of the detection results is designed based on 45 / SSC combination, so that it is possible to determine whether plasmocyte, B
lymphocyte clonality, and abnormal lymphoplasmacytoid are detected. The
antibody composition can be directly used for MRD detection of LPL, and can also be used for preparation of related kits.