Bifurcated vessel model and preparation method thereof

A blood vessel model and bifurcation technology, which is applied in the field of bifurcated blood vessel models and their preparation, can solve the problems of inability to make complex blood vessel structures, artificial blood vessel model preparation research and development without further breakthroughs, and unsatisfactory problems.

Active Publication Date: 2019-05-17
INST OF MEDICAL DEVICES (SUZHOU) SOUTHEAST UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, in the process of preparing the artificial blood vessel model, due to the special use of the artificial blood vessel model in biomedicine, the requirements for the size, temperature, non-toxicity, and purity of the prepared material are very strict, and due to the fragility of the artificial blood vessel model itself Due to strict r...

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  • Bifurcated vessel model and preparation method thereof
  • Bifurcated vessel model and preparation method thereof
  • Bifurcated vessel model and preparation method thereof

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Embodiment 1

[0033] see Figure 1-3 , a bifurcation vessel model proposed by the present invention.

[0034] Human blood vessels are a series of tubes through which blood flows throughout the whole body. According to different structures and functions, they can be divided into three types: arteries, veins, and capillaries. Since only straight blood vessels can be prepared in the prior art, or the biological functionality is low, in order to meet the needs of medical modeling, the present invention proposes a bifurcated blood vessel model, including main branch blood vessel pipeline and at least one branch blood vessel pipeline , the bifurcated blood vessel model includes biological hydrogel, proliferative smooth muscle cells or smooth muscle cell precursor cells that can differentiate into smooth muscle cells and mesenchymal stem cells, and the inner wall surface of the blood vessel includes a proliferative endothelial cell layer. Wherein, the content of smooth muscle cells or smooth musc...

Embodiment 2

[0044] The present invention proposes a method for preparing a bifurcated blood vessel model, specifically, comprising the following steps:

[0045] 1. Configure the generated mold:

[0046] The preparation of the bifurcated blood vessel model of the present invention mainly utilizes the principle and method of perfusion molding, therefore, firstly, the angiogenesis mold for perfusion molding is prepared. In this step, it mainly includes connecting the vessel wall cover component and connecting the bifurcation space-occupying component. The bifurcation space-occupying component is matched with the bifurcation blood vessel wall cover component to form a main branch blood vessel pipeline and at least one branch blood vessel pipeline. The generated mold can be used to design straight bifurcated vascular structures, and can also be used to design complex vascular structures, for example, can include certain curvature or radian; see image 3 .

[0047] Configuration of the gener...

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Abstract

The invention provides a bifurcated vessel model and a preparation method thereof. The bifurcated vessel model comprises a main vessel line and at least one branch vessel line. Materials of the bifurcated vessel model comprise biohydrogel, proliferous smooth muscle cells or smooth muscle cell precursor cells which can differentiate into the smooth muscle cells and mesenchymal stem cells. The content of the smooth muscle cells or the smooth muscle cell precursor cells is 1*10^6-10^7 cells per gram of biohydrogel, and the content of the mesenchymal stem cells is 1*10^5-5*10^6 cells per gram of biohydrogel. The vessel inner wall surface comprises a proliferous endothelium layer. The bifurcated vessel has good vascular function characteristics. A biological model and a disease model established by the bifurcated vessel can further satisfy the pathological research of diseases and the need for in vitro screening of a therapeutic drug.

Description

【Technical field】 [0001] The invention belongs to the field of artificial organs and organ chips in tissue engineering, and in particular relates to a model with bifurcated blood vessels and a preparation method thereof. 【Background technique】 [0002] The artificial blood vessels currently on the market are generally made of chemical materials such as synthetic polymers (such as ePTEF materials, polyethyleneterephthalatefibre). The artificial blood vessel models made of these materials are usually used to replace a small amount of blood vessels in the patient's body, usually larger Blood vessels (over 6mm in diameter). However, these artificial blood vessels are made of chemical materials, so the artificial blood vessels do not contain cells and living substances, so they have little biological functionality and are only used as a passage for a section of blood vessels. [0003] Existing biomaterials are used to prepare artificial blood vessels using a biomaterial stent me...

Claims

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Application Information

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IPC IPC(8): A61L27/38A61L27/24A61L27/20A61L27/50A61F2/06
Inventor 陈早早顾忠泽葛健军张静
Owner INST OF MEDICAL DEVICES (SUZHOU) SOUTHEAST UNIV
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