41 results about "Bilobol" patented technology

The present invention discloses a new ginkgodamole composition, medicine composition prepared hy using it, in particular, injection and their preparation method. Said ginkgodamole composition mainly contains the following components: (by wt%) 18-65% of ginkgo total flavone glycoside, 6-32% of dipyridamole, 4-25% of ginkgo total lactone and the heavy metal content is less than 9.4 ppm (weight), inwhich the ginkgo total lactone is formed from bilobalide, ginkgolide A, ginkgolide B and ginkgolide C according to the weight ratio of 4-40:7-40:3-30:3-40. Said medicine preparation, specially injection have obvious therapeutic effect for curing angiocardiopathy and cerebrovascular diseases.

The invention relates to application of ginkgol C17:1 in treatment of liver cancer, belonging to the field of biological drugs. The ginkgol C17:1 is prepared through a method comprising the following steps: preparing ginkgolic acid from gingko (leaves, fruits and episperm); performing heat treatment to decarboxylate the ginkgolic acid; and separating, and purifying to obtain the ginkgol C17:1, wherein structural identification shows that the ginkgol C17:1 has cis / trans isomeric structures. The prepared ginkgol C17:1 can effectively inhibit proliferation of human liver cancer cells SMMC-7721 and inhibit migration of the SMMC-7721 cells in vitro, and drug resistance can not be easily produced; and the prepared ginkgol C17:1 can inhibit growth of nude mouse loaded HepG solid tumors in vivo. The new application of the ginkgol C17:1 provided by the invention is of great importance in preparation of antitumor drugs and especially in preparation of anti-liver cancer drugs.

The invention relates to application of gingkolic acid in preparation of an external preparation for treating osmidrosis. The gingkolic acid comprises ginkgoic acid, ginkgol, ginkgo diphenol and the like, and can be extracted from leaf, fruit, external exotesta, rhizome and other parts of ginkgo through a chemical separation method. The osmidrosis includes the osmidrosis of axillary part, foot part, perineum and other parts. The drug, cosmetic or disinfectant external preparation containing gingkolic acid for treating osmidrosis contains 0.001-80wt% of gingkolic acid and a pharmaceutically common external preparation matrix or acceptable carrier; and the preparation is any one pharmaceutically external dosage form. Pharmacological experiment researches show that the external preparation has the effects of inhibiting the growth and propagation of bacteria on skin surface and permeating into skin to destroy large sudoriferous gland, and inhibiting the generation of free fatty acid, ammonia nitrogen compound and other smelling substances in sweat. Clinical trial shows that the external preparation has significant treatment effect on the osmidrosis, has effective rate up to 100%, is safe to use and has no side effect.

The invention discloses a whole ginkgo seed powder preparation method capable of reducing the content of bilobol and ginkgolic acid, and relates to the technical field of production methods achieving deep processing of ginkgo seeds. The method comprises the process steps of conducting hulling, rinsing and leaching on selected ginkgo seeds, smashing the ginkgo seeds for pulping, adding alkali for pulp conditioning and standing, conducting infrared drying and obtaining whole ginkgo seed powder. The prepared whole ginkgo seed powder has the advantage of being low in content of ginkgolic acid and bilobol, wherein the content of bilobol and the content of ginkgolic acid are reduced by 86%-83.6% and 60.5%-38.7% respectively compared with whole ginkgo seed powder prepared by being directly dried at 60 DEG C; the obtained product is good in rehydration characteristic, and the flavor and taste of the obtained product are closer to those of fresh ginkgo seeds.

The invention discloses a method for solid-state fermentation of Ginkgo powder by S. coronis and the product and application thereof. The method comprises: (1) preparing a spore suspension of S. coronis; (2) preparing ginkgo powder, adding Inorganic salts, adjust the pH to prepare a solid-state fermentation medium; (3) inoculate the spore suspension of S. coronoidis in the solid-state fermentation medium, and add sterile deionized water to adjust the initial water content, cultivate and add no Bacterial deionized water, after fermentation, the solid-state fermented ginkgo powder of Saccharomyces coronoidis is obtained. The present invention uses ginkgo powder as the base material for the solid-state fermentation of S. coronoidis. After fermentation, most of the nutritional components and functional components of the ginkgo powder are retained, and the ginkgophenolic acid and MPN in the ginkgo powder are effectively degraded. Due to the growth and metabolism of the fungus, the fermented ginkgo powder contains a large number of spores of the fungus, lovastatin, polysaccharide, α-amylase, protease and many other functional health ingredients, and the flavor is obviously improved.

The invention discloses lucid ganoderma-gingko wine, relating to the technical field of biological engineering. According to the wine provided by the invention, the alcoholic strength is 8-16%, the content of general flavone is 1-5 mg / L, the content of gingko lactone is 1-6 mg / L, the content of general terpenes compound is 30-800 mg / L, the content of protein is 60-200 mg / L, the content of ganoderic acid is 10-17 mg / L, the content of soluble sugar is 0-2.0%, the content of gingko phenolic acid is 0-5 ppm and the content of hydrocyanic acid is 0-0.1 microgram / liter. According to the preparationmethod provided by the invention, the gingko is hydrolyzed by utilizing a double-enzyme method to obtain a gingko hydrolyzing solution and the gingko hydrolyzing solution contains active compounds including gingko flavone, terpenes compounds, amino acid, peptides and starch and the like, wherein the content of the amino acid and the peptides is not less than 1% and the content of the starch is not less than 2%; the hydrolyzing solution is converted through lucid ganoderma strains and a rice mold culture is added to ferment to obtain fermentation liquor; the fermentation liquor is filtered andblended to obtain the lucid ganoderma-gingko wine. The wine provided by the invention contains the active components of the gingko and the lucid ganoderma and has the functions of preventing hypertension, resisting oxidization and the like.

The invention discloses a method for liquid state fermentation of Saccharomyces coronis and the product and application thereof. The method comprises: activating and separating Saccharomyces coronis, and preparing spore suspension; making ginkgo fruit into ginkgo nuts , adding water to grind, adding inorganic salts to prepare a liquid fermentation medium; inoculating the spore suspension of Cystis coronis in the liquid fermentation medium, and vibrating and culturing to obtain a liquid fermentation product of Cystis coronis. In the present invention, ginkgo is used as a liquid fermentation medium for the coronoid fungus, and after fermentation, most of the nutritional components and functional components of the ginkgo are retained, and the contents of ginkgolic acid and MPN are reduced. In addition, after fermentation, it contains a large number of spores of Cystis coronis, lovastatin, polysaccharides, α-amylase, protease and many other functional health ingredients, and the flavor is obviously improved. Its ginkgo fermented products can be used to prepare ginkgo products such as enzymes and beverages with the functions of regulating blood lipid, regulating immunity, anti-oxidation and anti-tumor.

The invention discloses a hydrophobic deep eutectic solvent used for liquid-liquid microextraction to remove ginkgolic acids in ginkgo biloba crude extract, a preparation method and a removal method thereof, wherein the hydrophobic deep eutectic solvent consists of menthol, hexanol and Lauric acid is prepared at a molar ratio of 1:0.9:0.1 to 1:0.4:0.6. The preparation of the hydrophobic deep eutectic solvent of the present invention is simple and fast; the hydrogen bond is stable, the fluidity is good, it is a green solvent, and has the characteristics of easy biodegradation, no pollution to the environment, and high biocompatibility; the hydrophobic deep eutectic solvent prepared by the present invention The method of liquid-liquid microextraction to remove ginkgolic acids in the crude extract of ginkgo leaves can reduce the content of ginkgolic acids in the crude extract of ginkgo leaves to less than 5ppm, while retaining the content of ginkgo flavonoids and terpenes in the crude extract of ginkgo leaves The content of functional components such as esters, the whole liquid-liquid micro-extraction removal method is simple, fast, safe, high removal efficiency, low cost, and will not cause harm to the environment and human body.