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Production method of water-soluble ginkgo biloba extract

A production method and technology of ginkgo biloba, applied in the production field of water-soluble ginkgo biloba extract, can solve the problems of waste, high production cost, high tannin content, etc., and achieve the effect of reducing production cost, short production cycle and good water solubility

Active Publication Date: 2020-12-08
HUNAN JINNONG BIOLOGICAL RESOURCES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this process, flavonoids are easily oxidized and lost due to repeated heating, extraction and concentration processes. Multiple filtration processes also easily lead to the loss of total lactone components, and the tannin content is high.
[0009] The preparation method of highly water-soluble ginkgo leaf extract disclosed in CN201811247088.1, the preparation process and water-soluble ginkgo leaf extract disclosed in CN201610149596.0, the highly water-soluble ginkgo leaf extract disclosed in CN201810341413.4 The preparation method is all to use standard Ginkgo biloba extract as raw material to obtain water-soluble Ginkgo biloba extract by dissolving or enzymolysis, repeated production process causes loss of flavonoid lactone and waste of energy consumption, high production cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The production method of the present embodiment water-soluble ginkgo extract comprises the steps:

[0039] (1) Extraction: Weigh 400Kg of the dried leaves of ginkgo seedlings (the raw material is the 2-year-old seedling leaves of Ningqiang, Shaanxi Province, harvested in June, with a flavonoid content of 1.35wt%, and a lactone content of 0.56wt%). After crushing, use a volume concentration of 75% 4800L of ethanol aqueous solution is used for percolation extraction, and the extraction temperature is 78~82°C;

[0040] (2) Concentration: Concentrate the extract obtained in step (1) by vacuum heating to no ethanol, add water 3 times during the concentration process, the concentration temperature is 48±2°C, the vacuum degree is -0.07~-0.08Mpa, and the density is 1.1 concentrate;

[0041] (3) Centrifugation and fine filtration to remove impurities: After cooling the concentrated liquid obtained in step (2) to less than 20°C, use a decanter centrifuge, and the drum speed of t...

Embodiment 2

[0047] The production method of the present embodiment water-soluble ginkgo extract comprises the steps:

[0048] (1) Extraction: Weigh 600Kg of the dried leaves of ginkgo seedlings (the raw material is the 2-year-old leaves of Ningqiang, Shaanxi, at the end of July, with a flavonoid content of 1.18% and a lactone content of 0.52%). After crushing, use ethanol with a volume concentration of 70% The aqueous solution is 6000L for percolation extraction, and the extraction temperature is 76±1°C;

[0049] (2) Concentration: Concentrate the extract obtained in step (1) by vacuum heating to no ethanol, add water twice during the concentration process, the concentration temperature is 43±2°C, the vacuum degree is -0.08~-0.09Mpa, and the density is 1.12 concentrates;

[0050] (3) Centrifugation and fine filtration to remove impurities: After cooling the concentrated liquid obtained in step (2) to less than 18°C, use decanter centrifugation, and the drum speed of the decanter centrifu...

Embodiment 3

[0056] The production method of the present embodiment water-soluble ginkgo extract comprises the steps:

[0057] (1) Extraction: Weigh 750Kg of the dry leaves of ginkgo seedlings (the raw material is the 2-year-old seedling leaves of Ningqiang, Shaanxi, harvested in August, the content of flavonoids is 1.19wt%, and the content of lactones is 0.47wt%). 6750L of 68% ethanol aqueous solution is used for percolation extraction, and the extraction temperature is 72~75°C;

[0058] (2) Concentration: Concentrate the extract obtained in step (1) by vacuum heating to no ethanol, add water twice during the concentration process, the concentration temperature is 43±2°C, the vacuum degree is -0.08~-0.09Mpa, and the density is 1.15 concentrate;

[0059] (3) Centrifugation and fine filtration to remove impurities: After cooling the concentrated liquid obtained in step (2) to less than 18°C, use decanter centrifugation, and the drum speed of the decanter centrifuge is 4000r / min; the centri...

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Abstract

The invention relates to a production method of a water-soluble ginkgo biloba extract. The production method comprises the following steps of (1) carrying out percolation extraction by using an ethanol aqueous solution; (2) concentrating and cooling the extracting solution; (3) performing centrifuging, finely filtering and removing impurities; (4) carrying out ester precipitation on a mixed solvent; (5) performing water precipitation; (6) performing deacidifying; and (7) performing drying to obtain the water-soluble high-lactone ginkgo biloba extract. According to the obtained water-soluble high-lactone ginkgo biloba extract, the flavone content is greater than or equal to 24.0%, the lactone content is greater than or equal to 10.0%, the normal-temperature water solubility is greater than10%, and the ginkgolic acid content is less than or equal to 1ppm. The produced ginkgo biloba extract is good in water solubility, and the content of lactone in the product is greatly increased. The production cost is low, the operation is simple, and the method is suitable for large-scale production.

Description

technical field [0001] The invention relates to a production method of water-soluble ginkgo leaf extract. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba plant, also known as ginkgo leaf. According to "Diet Therapy Materia Medica", Ginkgo biloba can be used for the treatment of palpitations, lung deficiency cough and asthma. Ginkgo biloba extract (GBE) is a light yellow powdery substance extracted and purified from the dried leaves of Ginkgo biloba, which contains flavonoids, terpene lactones, ginkgo sugars, and other active substances. nutrient content. Ginkgo biloba extract mainly has the following health functions: promoting body circulation, anti-oxidation, delaying aging, improving memory, preventing and treating high blood pressure, and regulating blood sugar. Ginkgo biloba extract is currently recognized worldwide as the most ideal drug ingredient for the treatment and prevention of cardiovascular and cerebrovascular diseases. [0003] Gin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K8/9771A23L33/105
CPCA61K36/16A61K8/9771A23L33/105A61K2236/333A61K2236/51A61K2236/53A61K2800/805A61K2800/84A23V2002/00A23V2250/2122A23V2300/14A23V2300/38A23V2300/40
Inventor 范水源龙伟岸金慧罡王乐饶昆殷梦龙
Owner HUNAN JINNONG BIOLOGICAL RESOURCES
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