37 results about "Anticoagulation Treatment" patented technology

Thrombolytic and / or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and / or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.

The invention discloses a method for extracting modified plasma protein powder and bioactive peptide for enriching blood from pig blood, comprising the following steps of: taking fresh and healthy pig blood as a raw material; carrying out anticoagulation treatment, centrifuging and separation on the fresh and healthy pig blood to obtain a blood cell and blood plasma; carrying out high-pressure cutting and wall breaking, complex enzyme hydrolysis and flashing and deodorizing process treatment on the blood cell to obtain enzymolysis liquid; carrying out rough filtration, fine filtration, condensation treatment and spray drying to obtain the bioactive peptide for enriching the blood; and carrying out modification treatment on the separated blood plasma to obtain the plasma protein powder. The invention has the following advantages that: 1. the production cost is low and no pollution to the environment is generated; 2. the average molecular weight of small peptide of the produced bioactive peptide for enriching the blood is not more than 10,000Dalton, the content of free amino acid is not more than 15.0percent and the protein of the plasma protein powder is not less than 90.0 percent; 3. the water content of the produced modified plasma protein is not more than 5.0 percent, the viscosity (5 percent solution) is not less than 2.0 mpa.s and the content of the protein is not less than 90.0 percent; and 4. the process method saves time and energy, has simple operation and fully utilizes pig blood resources.

The invention relates to a method for preparing a liquid porcellanite activating partial thromboplastin (APTT) reagent. The reagent is mainly used for monitoring coagulation factor deficiency of endogenous coagulation systems and carrying out screening test of related inhibitors, and used for detecting coagulation factors, heparin anticoagulation treatment and lupus anticoagulation substances as the current main means. Taking porcellanite as an activating agent, the method improves the sensitivity to the coagulation factors; a novel stable system solves the problem of keeping the stability of the reagent at a liquid state; and the method has the advantages of high sensitivity, convenient use, small experimental error, strong stability, good compatibility, low cost and the like.

The aim of the present invention is to provide a health silk stockings produced using nanometer silver antibiotic material. The solution of the present invention is that to obtain nanometer stage silver particle (1 nanometer is equal to billionth meter) combining electrical arc method and mechnical rubbing method, then to implement antioxidation and anticoagulation treatment to the particles, at last to prepare nanometer silver antibiotic solution. To dip in the silk stockings in the nanometer silver antibiotic solution which temperature is 80 to 95 DEG C for 24 to 48 hours, then to take out and airing as well as iron out, so that the health silk stockings of the present invention is made. The silk stockings of the present invention has strong antibiotic effect, moreover, it is ventilating and flexible which ensure feet to be dry, the antibiotic effect is durable, also it has the deodorization effect, as well as release anion and far infrared energy, so it is a health silk stockings with complete function.

The invention relates to a method for extracting superoxide dismutase (SOD) from porcine blood red cells, in the method, anticoagulation treatment is adopted for preventing blood coagulation and breaking of blood cells. Colloid mill breaking and low-temperature swelling are adopted for releasing matters dissolved in the blood cells to the maximum extent so as to get hemolysate. Thermal change is performed on the hemolysate twice for removing impurities, removing hemoglobin and a large number of impurity proteins so as to get SOD crude enzyme liquid, and ultrafiltration concentration, gradient elution, dialysis, salt removal and freeze-drying are further performed on the SOD crude enzyme liquid so as to get an SOD product. The method is simple to operate and easy to master; furthermore, by adopting the method, the product quality can be effectively improved, the production cost can be reduced, the production cycle can be shortened, the production efficiency can be improved, and the method is applicable to industrialized production.

The invention relates to a method for extracting hemin and globin by the use of leech protease with animal blood as a raw material. The method comprises the following main steps of: 1, carrying out middle-temperature extraction to prepare leech protease for later use; 2, taking fresh animal blood, carrying out anticoagulation treatment, centrifuging and collecting hemoglobin cells; 3, adding one time of pure water, carrying out ultrasonic treatment and breaking cells; 4, filtering through a screen mesh, leaving a filtrate, and adjusting pH value; 5, adding leech protease for enzymatic hydrolysis; 6, adjusting pH value of an enzymatic hydrolysis liquid and carrying out centrifugal separation; and 7, washing a sediment which has undergone centrifugation, carrying out dehydrolysis and drying to obtain hemin; letting a supernatant which has undergone centrifugation pass through a microfiltration membrane to remove impurities, using a nanofiltration membrane for concentration, and carrying out dehydrolysis and drying on a concentrate to obtain globin. According to the invention, animal blood resources are fully utilized and the leech extract product is used as an enzyme preparation to produce hemin and globin with high added values. The technology is simple and easy to operate, the production cost is low, and the method is suitable for industrial production.

The present invention discloses a preparation method of compound vaccinium bracteatum leaf juice duck blood tofu. The preparation method comprises the following steps: vaccinium bracteatum leaf juiceis added into duck blood after an anticoagulation treatment to prepare compound duck blood, the compound duck blood is coagulated and the coagulated duck blood is cured to obtain the duck blood tofu;wherein a volume ratio of the vaccinium bracteatum leaf juice to the duck blood is 1:(3.5-5). The preparation method can cover the smell of the duck blood tofu, also can have certain anti-oxidation, anti-decay and anti-micro-organism effects, and prolongs shelf life of the duck blood tofu. At the same time, the produced duck blood tofu is uniform in color and luster, and smooth in cutting surfaces.

The invention relates to special flavor pork skin paste and a production method thereof and belongs to food processing technologies. Fresh pork skin or thawy quickly-frozen pork skin is subjected to cleaning, rinsing, impurity removal, peculiar smell removal and particle adjustment and then is subjected to softening and anticoagulation treatment. An appropriate amount of vegetable oil, soybean paste or flour paste and aromatic seasoning are added into softened and anti-coagulated pork skin, and paste type seasoning having special flavor and smooth and mellow taste is produced through flavor enhancing and cooking treatment. The production method changes the situation that existing pork skin only can be used in solid foods and chemical materials, improves the ductility and the spreadability of pork skin foods, enables products to be easily absorbed, enables the nutritive value to be improved and enables the seasoning to be delicious and tasty.

Each 100 ml of blood anticoagulant contains trisodium citrate 3.31-3.32g, citric acid 0.01-0.05g, glucose 2.45-3.37g and the rest is water. The tests show that after the external blood is undergone the process of anticoagulation treatment it can prolong the stroage life of lymphocyte to 48-72 hr. from original 4-6 hr. Said invention also provides its application method.

The invention discloses a medical care interaction system for preventing and treating venous thromboembolism of inpatients. The system is composed of a patient scoring system, a patient risk estimation system, a patient prevention intervention operation system, a patient informed agreement signing system and a background data capturing system. The patient scoring system outputs data to the patientrisk estimation system; the patient risk estimation system outputs data to the patient prevention intervention operation system, the patient prevention intervention operation system receives the dataand then presents the data to a doctor, the output end of the patient prevention intervention operation system is connected with the input end of the patient informed agreement signing system, and the background data capture system captures nursing evaluation information and doctor intervention information. The VTE morbidity of inpatients is effectively reduced, the important indexes such as theVTE risk assessment rate, the preventive measure implementation rate, the ratio of implementing anticoagulation treatment on the inpatients, the VTE detection rate and the hospital related lethal VTEoccurrence rate are focused on, and the social benefits and economic benefits of VTE prevention and treatment are remarkably improved.

The invention relates to a preparation method for producing pig haemocyte active small peptide powder through a one-step method. The preparation method mainly comprises the steps of collecting fresh pig blood subjected to anticoagulation treatment, conducting centrifugal separation to obtain haemocyte liquid, conducting hemolysis, enzymolysis and centrifugation to obtain enzymatic hydrolysate, conducting ultrafiltration membrane filtration and nanofiltration membrane concentration on the enzymatic hydrolysate, and then conducting spray drying, so that the pig haemocyte active small peptide powder is obtained. According to the preparation method, efficient endo protease is selected, the one-step method is adopted, the ultrafiltration membrane and nanofiltration membrane separation technology is combined, the process procedure is simple, the production cycle is short, production efficiency is high, cost is low, and the preparation method is suitable for large-scale industrialized production. In the prepared pig haemocyte active small peptide powder, the content of active small peptide (with the relative molecular weight ranging from 180 Da to 1000 Da) reaches 75% or above, the content of organic hemin (heme iron) reaches 0.2% or above, the content of ash is lower than 5.0%, and the content of free amino acid is lower than 11%. The product can promote growth of animals and enhance immunity and disease resistance of animals and is a novel functional protein feed raw material.

The invention discloses a novel process for extracting superoxide dismutase SOD from animal blood cell liquid. The process mainly comprises the following steps of: after carrying out anticoagulation treatment on animal fresh blood, centrifuging and separating blood cells; carrying out hemolysis, thermally denaturing, super-filtering and concentrating, and then carrying out fractional precipitation by acetone to obtain a rough product of the SOD; subjecting the rough product of the SOD to chromatographic purification, and then freezing and drying to obtain a competitive product of the SOD. In the process provided by the invention, chloroform ethanol is abandoned and transitional metal salt which is any one of copper salt, zinc salt and manganese salt in the process of thermally denaturing is not added; a ultra-filtering and concentrating process is further introduced on the base and the use amount of the acetone in the process of carrying out the fractional precipitation by acetone is extremely small. The novel process for extracting the SOD guarantees the activity of the traditional SOD to the maximum extent, has the advantages of simplicity in operation and low cost and is suitable for large-scale industrial production.

A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.

The invention discloses a processing method of flavored sheep / goat lung crisp chips. Through anticoagulation treatment, bloodstain in blood vessels of sheep / goat lung is effectively eliminated, the color of the sheep / goat lung is maintained to be bright, the putrid and deteriorated process of the sheep / goat lung is alleviated, and blood smell is eliminated; through technologies of alkaline washingand kneading, ultrasonic vibration, rinsing and dehydration and the like, endocrine substances and metabolism dirt of lung tracheas are thoroughly eliminated, sheep / goat odor is removed to the maximum extent, and peculiar smell of the sheep / goat lung is reduced; and unique flavor of steamed eel in black bean sauce is creatively used as seasoning, and the flavor feature of the sheep / goat lung crisp chips is improved. According to the processing method disclosed by the invention, on the base of creating a washing technology and reinforcing sheep / goat odor eliminating effects, the unique flavorof the steamed eel in black bean sauce is utilized as the seasoning, so that the sheep / goat odor is better covered, the individual flavor feature of the sheep / goat lung crisp chips is increased, new snack foods in great demand namely the sheep lung crisp chips are created, and high-value development of sheep / goat entrails is realized.

A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.

To provide a technology that allows for simple and highly accurate evaluation of the condition of blood.Provided is a blood condition analysis device, for analyzing the condition of a blood sample having added thereto at least one kind of drug selected from the group consisting of anticoagulation treatment canceling agents, coagulation activators, anticoagulants, platelet activators, and antiplatelet agents, the device including a drug dosage control unit for controlling the dosage of the drug to be added to the blood sample on the basis of the hematocrit and / or hemoglobin content of the blood sample.

The invention provides a kit for detecting functions of coagulation and platelets of heparin-added blood samples and application thereof and relates to the technical field of medical apparatus and instruments. The detection kit comprises a reagent cup and a detection probe, wherein glass beads and a stirring rod are arranged in the reagent cup; the reagent cup also comprises a cup lid; the reagentcup is tightly bonded with the cup lid; a groove is formed in the center of the cup lid and is used for mounting the detection probe; heparinase I is arranged in the reagent cup. The detection kit takes the glass beads as activators, is capable of detecting the functions of coagulation and platelets of heparin-added blood samples through an in-vitro coagulation activating method, has great significance to early discovery of the risk of thrombosis of patients, guidance of anticoagulation treatment and component blood transfusion, and diagnosis and treatment of platelet-related diseases, and iscapable of making up the defects of detection of the functions of coagulation and platelets of the heparin-added human blood in the in-vitro study field at present.

The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of TFPI-2 in a sample from the subject, and comparing the amount of TFPI-2 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to methods for assessing anticoagulation therapy and to methods for predicting the risk of stroke of a subject. Said methods are based on the determination of the amount of TFPI-2 in a sample from the subject.

The invention discloses a platelet extraction method which comprises the following steps: carrying out at least two-stage centrifugal treatment on a whole blood sample subjected to anticoagulation treatment, and extracting platelets from an upper plasma layer obtained after each centrifugal treatment, mixing an upper platelet-deficient plasma layer separated after the last centrifugal treatment with a lower blood cell layer separated after the first centrifugal treatment to prepare a whole blood sample again, performing centrifugal treatment on the newly prepared whole blood sample, extracting platelets from the separated upper platelet-rich plasma layer again to obtain the platelet-rich plasma, and mixing and collecting all extracted platelets. The platelet extraction method disclosed by the invention has the advantages of simplicity in operation, high platelet acquisition rate and high acquisition number of large platelets.

The invention relates to special flavor pork skin paste and a production method thereof and belongs to food processing technologies. Fresh pork skin or thawy quickly-frozen pork skin is subjected to cleaning, rinsing, impurity removal, peculiar smell removal and particle adjustment and then is subjected to softening and anticoagulation treatment. An appropriate amount of vegetable oil, soybean paste or flour paste and aromatic seasoning are added into softened and anti-coagulated pork skin, and paste type seasoning having special flavor and smooth and mellow taste is produced through flavor enhancing and cooking treatment. The production method changes the situation that existing pork skin only can be used in solid foods and chemical materials, improves the ductility and the spreadability of pork skin foods, enables products to be easily absorbed, enables the nutritive value to be improved and enables the seasoning to be delicious and tasty.

The invention discloses a model for predicting the anti-coagulation bleeding risk of rivaroxaban and application of the model, and belongs to the technical field of biological detection. The model comprises a data input unit, an assignment unit, a curative effect prediction unit and a report output unit for two independent risk factors of a CYP3A4 genotype and a clinical bleeding history of a detected object, and a Camp is formed according to the units; b, the scoring system is used for counting according to the total score of 3, if Camp; the score B is less than or equal to 1, and rivaroxaban can be used as a blood coagulation factor X inhibitor for anticoagulation treatment; if Camp; the score B is greater than or equal to 2, and warfarin can be selected for anticoagulation treatment. The model can be used for guiding a clinician to accurately select a blood coagulation factor X inhibitor, a rivaroxaban bleeding risk prediction result is accurate and reliable, and a balance can be obtained between anticoagulation benefit and bleeding risk.

The invention provides a preparation method of a sheep peripheral blood lymphocyte transfer factor solution, which comprises the following steps: collecting fresh sheep blood, carrying out anticoagulation treatment, and carrying out cell sedimentation and separation; collecting a lymphocyte layer, and diluting the collected lymphocytes with Hank's liquid to prepare a lymphocyte seed suspension for later use; performing cell suspension culture on the lymphocyte seed suspension to obtain lymphocyte liquid; the lymphocyte fluid is subjected to cell disruption, the disrupted cells are filtered and ultra-filtered through a microfiltration membrane and an ultra-filtration membrane respectively, and ultra-filtrate is the obtained transfer factor solution; the invention also provides an injection which is prepared by performing sterile filtration on a transfer factor solution and then adding mannitol and normal saline. According to the method, sheep leukocytes are used as a culture medium, a cell suspension culture process is adopted for enlarged culture, the prepared transfer factor solution, namely the injection, can be suitable for large-scale production, and the yield is greatly improved.

The invention discloses a traditional Chinese medicine composition for treating long-term anticoagulation for patients with atrial fibrillation and a preparation method of the traditional Chinese medicine composition, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 10-20 parts of Chinese angelica, 10-20 parts of peach kernels, 15-45 parts of safflowers, 10-20 parts of trichosanthes, 10-20 parts of bitter oranges, 10-20 parts of twotooth achyranthes roots, 2-9 parts of sanchi, 5-15 parts of platycodon grandiflorum, 5-15 parts of tangerine peels, 5-15 parts of red peony, 10-20 parts of Chinese thorowax roots and 3-5 parts of dragon blood. An experiment proves that the traditional Chinese medicine composition can be used for preventing or treating atrial fibrillation, especially severe bleeding complications which are caused during prevention treatment of atrial fibrillation anticoagulation; meanwhile, the composition also has the characteristics of activating blood and removing stasis and inspiring vital energy and blood, and is mild in drug properties, and warm heat and dryness heat are avoided; the pathological factors such as vascular endothelial injury and intravascular vortex formation can be effectively corrected, and the prognosis of large vascular restenosis and occlusion can be improved.

The invention discloses a preparation method and an application for an oral solution containing Panax ginseng, Codonopsis pilosula, radix scrophulariae, radix ginseng Rubra, radix salviae miltiorrhizae and astragalus membranaceus. The preparation method for porcine protein-free serum comprises the following steps: taking pig blood for anticoagulation treatment and denaturation treatment, and collecting a first filtrate; concentrating the first filtrate so as to obtain a first concentrate, carrying out centrifuging, allowing a supernate to flowing into a column mixing bed, collecting an effluent liquid, and carrying out filtering so as to obtain a second filtrate; allowing the second filtrate to flow through an ultrafiltration column, and collecting a permeate; and concentrating the permeate so as to obtain a second concentrate, adding medicinal active carbon, carrying out adsorption treatment, carrying out heating to 80 DEG C, carrying out filtering, blending the filtrate, filling thefiltrate into an oral liquid bottle, carrying out sealing and sterilizing, and carrying out storing in a shade place. The porcine protein-free serum obtained by using the preparation method provided by the invention reaches a dry matter content and a trace element content respectively up to 75.1% and 0.092%, and has trace elements with a content higher than the average level of the trace elementscontained in human serum. The porcine protein-free serum provided by the invention is used for preparing the oral solution containing Panax ginseng, Codonopsis pilosula, radix scrophulariae, radix ginseng Rubra, radix salviae miltiorrhizae and astragalus membranaceus, and has obvious treatment effects on gastric ulcer and duodenal ulcer.

The invention discloses a preparation method and application of Wushenqi oral solution. The preparation method of the pig protein-free serum comprises: taking pig blood for anticoagulant treatment and denaturation treatment, collecting the first filtrate; the first filtrate is concentrated to obtain the first concentrated solution, and after centrifugation, the supernatant is taken to flow through the column mixed bed, and the effluent is collected. Liquid, filtered to obtain the second filtrate; flow the second filtrate through the ultrafiltration column to collect the permeate; concentrate the permeate to obtain the second concentrate, add pharmaceutical grade activated carbon for adsorption treatment, heat up to 80 °C and filter, the filtrate is passed through After preparation, fill it into an oral liquid bottle and seal it, and store it in a cool place after sterilization. The pig protein-free serum obtained by the preparation method of the invention has dry matter content and trace element content as high as 75.1% and 0.092% respectively, and the trace element content is higher than the average level of trace element contained in human serum. The Wushenqi oral solution prepared by the pig protein-free serum provided by the invention has obvious therapeutic effects on gastric and duodenal ulcers.

The invention relates to a method and device for extracting platelet-rich plasma from blood. The method comprises the steps that a conical head of a first injector containing blood subjected to anticoagulation treatment faces downwards, the first injector is centrifuged for 5-45 minutes at the relative centrifugal force of 300-3000 g, and the content in the first injector is divided into a platelet-poor plasma layer, a platelet-rich plasma layer and a red blood cell layer from top to bottom; the conical head of the first injector is kept downward, and the red blood cell layer in the first injector is transferred into a collecting container through a communicating piece; the conical head of the first injector is kept downward, and the platelet-rich plasma layer in the first injector is transferred into the second injector through the communicating piece, so that only the platelet-rich plasma layer is contained in the second injector; and the platelet-rich plasma in the second injector and the blood coagulation agent in the third injector transferred to a spraying device, the platelet-rich plasma and the blood coagulation agent are mixed in the spraying device to generate platelet-rich gel, and the platelet-rich gel is sprayed from the spraying device.

The invention is suitable for the field of biomedical experiments, and provides a preparation method of an interstitial fluid. The method comprises the following steps: step 1, collecting blood of a healthy person or an experimental animal; step 2, carrying out anticoagulation or non-anticoagulation treatment on the blood, and performing centrifuging to obtain plasma or serum; step 3, adding the serum or the plasma into a filter of an ultrafiltration tube, embedding the filter into a nested tube, carrying out centrifugal operation, and collecting a liquid in the nested tube to obtain a pretreated liquid; step 4, adjusting the pH value of the pretreated liquid to 7.1-7.3 by using a sodium citrate buffer solution to obtain a primary interstitial fluid; and step 5, filtering and sterilizing the preliminary interstitial fluid by using a 0.22-micron microporous filter membrane to obtain the interstitial fluid. Components of the interstitial fluid obtained through the method are close to those of real interstitial fluid, and the interstitial fluid can meet biomedical experiment requirement and has good safety.