Model for predicting rivaroxaban anticoagulation bleeding risk and application thereof

A rivaroxaban and model technology, applied in medical simulation, genomics, instruments, etc., can solve problems such as poor results, achieve accurate and reliable results, avoid severe bleeding, and balance anticoagulant efficacy and bleeding risk

Pending Publication Date: 2022-08-05
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The study also tried a modified HAS-BLED to assess the bleeding risk of rivaroxaban, but the effect was not good
Therefore, there is currently no scoring tool to predict the bleeding risk of the new anticoagulant rivaroxaban

Method used

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  • Model for predicting rivaroxaban anticoagulation bleeding risk and application thereof
  • Model for predicting rivaroxaban anticoagulation bleeding risk and application thereof
  • Model for predicting rivaroxaban anticoagulation bleeding risk and application thereof

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Embodiment Construction

[0028] In order to make the purpose, technical solutions and advantages of the embodiments of the invention more clear, the following will be combined with the attached figures of the invention to clearly and complete the technical solutions of the embodiments of the present invention. Obviously, the embodiments described are some embodiments of the present invention, not all embodiments. Based on the embodiments of the invention described, all other embodiments obtained by ordinary technical personnel in the art under the premise that they do not need creative labor are the scope of the protection of the invention.

[0029] Unless another definition, the technical term or scientific term used here should be understood by people with general skills in the field of the invention. The "first", "second" and similar words used in the patent application of the invention and claims do not represent any order, quantity or importance, but only to distinguish different components. Similarl...

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Abstract

The invention discloses a model for predicting the anti-coagulation bleeding risk of rivaroxaban and application of the model, and belongs to the technical field of biological detection. The model comprises a data input unit, an assignment unit, a curative effect prediction unit and a report output unit for two independent risk factors of a CYP3A4 genotype and a clinical bleeding history of a detected object, and a Camp is formed according to the units; b, the scoring system is used for counting according to the total score of 3, if Camp; the score B is less than or equal to 1, and rivaroxaban can be used as a blood coagulation factor X inhibitor for anticoagulation treatment; if Camp; the score B is greater than or equal to 2, and warfarin can be selected for anticoagulation treatment. The model can be used for guiding a clinician to accurately select a blood coagulation factor X inhibitor, a rivaroxaban bleeding risk prediction result is accurate and reliable, and a balance can be obtained between anticoagulation benefit and bleeding risk.

Description

Technical field [0001] The present invention is a model and application of the risk of anticoagulant bleeding from Livachabane's anticoagulation bleeding in biological testing technology. Background technique [0002] Liva-Ban is a kind of coagulation factor X inhibitor, which is widely used in patients with non-valuvular fibrillation (NVAF) to reduce the risk of stroke and systemic embolism. As a new type of oral anticoagulant, Lidshabane is fixed and does not need to be monitored frequently, which is more likely to be accepted by patients. However, severe bleeding events such as intracranial hemorrhage and fatal bleeding still occur during the treatment of Liavarban, although the research shows that its incidence is lower than Huafalin. [0003] The reason is that during the treatment of sharp dynamics (PK) and Pharmacodynamics (PK) during the treatment There are differences in the concentration of the blood drugs of Shaban, and the research results show that the concentration ...

Claims

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Application Information

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IPC IPC(8): G16B5/00G16B20/50G16H50/30G16H50/50
CPCG16B5/00G16B20/50G16H50/30G16H50/50
Inventor 李晓烨余梅香王梓李晓宇吕迁洲
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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