171 results about "Cerebral arteries" patented technology

Devices and methods for delivering stents to target vessel regions, including stent delivery through microcatheters to narrow cerebral arteries. One stent delivery device includes a stent having the distal region everted over the distal end of a delivery tube, having the everted stent distal end captured by a distal element of a elongate release member disposed through the delivery tube. The delivery tube can have a distal taper to a small profile distal end. The everted stent distal region can be captured between the release member distal element and the surrounding delivery tube distal region walls. The captured and everted stent can be distally advanced to a target site, followed by manipulating the release member to free the captured stent. Some devices utilize distal advancement of the release member while other devices use proximal retraction of the release member to free the captured stent distal end. Once released, the stent is free to self-expand or be expanded against the surrounding blockage and / or vessel walls. In some methods, a guide catheter or microcatheter is also included and disposed about the everted and captured stent to advance the stent, delivery tube, and release member to a location near the site to be stented. The devices and methods provide stent delivery not requiring an enclosing delivery sheath about the stent. The everted stent can thus have a very small distal profile enabling small diameter vessels to be crossed and treated.

A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

The present invention provides a method and system for determining the cerebral hemodynamic model for depression, using carotid duplex ultrasound to establish percent stenosis of the extracranial right and left internal carotid arteries and transcranial Doppler ultrasound instrument to measure mean flow velocity within the cerebral including the right and left internal carotid arteries, right and left middle cerebral arteries, right and left anterior cerebral arteries, right and left posterior cerebral arteries, and basilar artery. The percent carotid stenosis and the mean flow velocity values in cerebral arteries are used to determine the cerebral hemodynamic model associated with depression in men and women, respectively.

Thrombolytic and / or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and / or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.

Disclosed is ultrasonic medical probe (10) connectable to a Doppler signal generator and processor for detecting or measuring blood flow in a vessel. In one embodiment, the distal portion (52) of the probe comprises an outer sheath (17) that includes a malleable shapeable portion (16), such as an annealed stainless steel cannula, to which a transducer head (11) containing one or more ultrasonic transducers (12), is mounted distally. Two wires (14, 15), comprising the electrical conductor (13), extend through the outer sheath from each ultrasonic transducer to a proximal connector (19). The shapeable portion can be contoured before or during a procedure, such as to access the natural spaces within brain to read flow in a cerebral artery. Other disclosed embodiments includes a shapeable portion that includes a malleable core wire (33) around which the wires are wrapped, an electrical conductor comprising malleable wires (36, 37) that are shapeable, a transducer head that is extendable from inside the outer sheath, and a handle portion (18) that is axially moveable for adjusting the length of the shapeable portion.

Methods and systems are provided for treating a vascular structure having a defect, for example, a cerebral artery having a weakened wall that has formed an aneurysm. The methods include substantially entrapping a quantity of blood within a vascular defect, and introducing a quantity of a crosslinking agent, for example as a liquid solution, into the entrapped blood. The crosslinking agent is a compound in which each molecule of the compound has at least two nucleophilic-reactive functional groups. The crosslinking agent is allowed to combine with and react with the substantially entrapped blood, and a substantially solid mass made of crosslinked blood is formed within the defect.

The invention relates to a composite of active ingredients of Chinese herb medicine used for preventing the damage of cerebral ischemia and relevant diseases, in particular to a preparation which is prepared by the active ingredients of the Chinese herb medicine; the preparation is prepared by the active ingredients of the Chinese herb medicine and the conventional preparation technique which is used by carriers permitted by pharmacy, and comprises the following components with the parts by weight: 2 to 10 parts of ginsenoside Rb, 2 to 10 parts of ginsenoside Rg1, 1 to 5 parts of ginsenoside Rd, 1 to 5 parts of ginsenoside Re, 2 to 10 parts of stilbene glycoside, 1 to 5 parts of ginkgolide and 1 to 5 parts of flavonoid mixture which consists of kaempferol and quercetin with the weight rate to be 1:1. The invention has the advantages that the defects that in the traditional compounded Chinese medicine, the composition is complex, the product quality is not controlled effectively and the curative effect is not stable are overcome, has clear ingredients, definite effect, stable quality and obvious control effect on ischemic stroke, sequela, cerebral arteriosclerosis and vascular dementia, can improve the functions of motor nerve, and learning and memory of the patients, has low toxicity and simple preparation method without obvious side effect and is suitable for industrial mass production.

A suction catheter system is described with a suction extension interfaced with a guide catheter to form a continuous suction lumen extending through a portion of the guide catheter and through the suction extension. The suction extension can be positioned by tracking the suction nozzle through a vessel while moving a proximal portion of the suction extension within the lumen of the guide catheter. The suction extension can comprise a connecting section with a non-circular cross section for interfacing with the inner lumen of an engagement section of the guide catheter. The tubular body of the guide catheter can have a reduced diameter distal section the can be useful to restrain the movement of the suction extension.

The present invention aims to provide an intravascular temporary occlusion balloon catheter that can itself function as a guidewire, has superior maneuverability suitable for highly tortuous or branched blood vessels such as coronary or cerebral arteries, can be inserted into the blood vessel over the guidewire, and can be sufficiently inserted into the peripheral region of the blood vessel. The present invention includes a balloon composed of a highly tensile material having an elongation at break of 300% to 1,100% and a shaft composed of a highly elastic material and having an outer diameter in the range of 0.014 in. to 0.018 in. and a bending modulus of at least 1 GPa, wherein a lumen for tracking the guidewire is provided at a catheter distal-end portion only.

The systems and methods described herein include a non-invasive diagnostic tool for intracranial hypertension (IH) detection and other neurological conditions like mild and moderate TBI that utilizes the transcranial Doppler (TCD) measurement of cerebral blood flow velocity (CBFV) in one or more cerebral vessels. A headset includes a TCD scanner which automatically locates various cerebral arteries and exerts an appropriate pressure on the head to acquire good CBFV signals.

The systems and methods described herein include a non-invasive diagnostic tool for intracranial hypertension (IH) detection and other neurological conditions like mild and moderate TBI that utilizes the transcranial Doppler (TCD) measurement of cerebral blood flow velocity (CBFV) in one or more cerebral vessels. A headset includes a TCD scanner which automatically locates various cerebral arteries and exerts an appropriate pressure on the head to acquire good CBFV signals.

Described is a method for deploying a stent-graft in the aorta, the method including positioning a shunt to go along a portion of a brain-supplying artery (BSA) into the aorta; deploying a stent-graft in the aorta along a portion of the shunt; and removing the shunt. Also described is a removable shunt adapted for deployment along a brain-supplying artery into an aorta to supply blood to the artery during deployment of a stent-graft in the aorta, the removable shunt including a stiff segment that is stiff enough to remain at least partially open when between the aorta and the stent-graft and large enough to allow sufficient blood supply to the brain during the deployment of the stent-graft; and a mechanism for facilitating safe removal of the shunt from between the stent-graft and the aorta. Also described is a method of deploying a branch stent graft having a flaring portion in a blood vessel branching at a bifurcation from an aorta to connect to an aortic stent graft deployed in the aorta across the bifurcation, a branch stent-graft useful in the method, and a delivery system useful in the method.

A suction catheter system is described with a suction extension interfaced with a guide catheter to form a continuous suction lumen extending through a portion of the guide catheter and through the suction extension. The suction extension can be positioned by tracking the suction nozzle through a vessel while moving a proximal portion of the suction extension within the lumen of the guide catheter. The suction extension can comprise a connecting section with a non-circular cross section for interfacing with the inner lumen of an engagement section of the guide catheter. The tubular body of the guide catheter can have a reduced diameter distal section the can be useful to restrain the movement of the suction extension.

The invention discloses a cerebral aneurysm endovascular plastic repair bracket and a conveying device thereof, and solves a technical problem of treating small blood vessels and particularly cerebral aneurysm in a human body. The repair bracket is a netlike cylinder which is wove by elastic alloy wires with diameter of 30-50mum followed by heat treatment to form an elasticated net taking a cylinder shape in a free state, two end portions of the netlike cylinder is sparsely wove and a middle portion is closely wove to form a compact section. In the conveying device, a microcatheter is internally provided with a bracket folded in a straight line shape, a guide wire passes through the bracket, two ends of the bracket is connected with the guide wire by a pushing ring, and the bracket is the netlike cylinder. Compared with the prior art, the bracket composed of short diameter and soft alloy wires benefits isolating cerebral arteries bearing an aneurysm from a cerebral aneurysm neck, reducing thrombosis caused by impact of blood in the arteries bearing the aneurysm on the cerebral aneurysm body and separating the cerebral aneurysm body from the arteries bearing the aneurysm, thus the bracket is applicable to treatment of fusiform cerebral aneurysm.

An X-ray computed tomography apparatus calculates transfer functions h(t) using a time-concentration curve Ca(t) for pixels of a cerebral artery and a time-concentration curve Ci(t) for pixels of cerebral tissues including capillary vessels and then calculates a delay time for each pixel of an object region from a time when an artery curve rises on the basis of the transfer functions. Further, the apparatus differently produces a visual color map showing time differences of blood flow conditions and provide it in a predetermined form by coloring pixels with a time delay from the other pixels without a time delay on the basis of the calculated delay time.

Methods and systems are provided for treating a vascular structure having a defect, for example, a cerebral artery having a weakened wall that has formed an aneurysm. The methods include substantially entrapping a quantity of blood within a vascular defect, and introducing a quantity of a crosslinking agent, for example as a liquid solution, into the entrapped blood. The crosslinking agent is a compound in which each molecule of the compound has at least two nucleophilic-reactive functional groups. The crosslinking agent is allowed to combine with and react with the substantially entrapped blood, and a substantially solid mass made of crosslinked blood is formed within the defect.

The Access guide catheter provides passage for therapeutic and diagnostic devices through vessels or conduits that return substantially in a direction from which they originated. One application is for delivery of therapeutic catheters to the carotid or cerebral arteries via access from the radial or brachial artery. The guide catheter enters the aorta from one of the great vessels, forms a closed loop in the aorta, and is directed back into a great vessel in an opposed direction. The distal portion of the guide catheter is advanced into the great vessel for support. Further support is attained by providing tension to the proximal shaft of the guide catheter. Flexibility of the guide catheter allows diagnostic angiograms to be performed prior to delivery of a therapeutic catheter or device.

The present invention is a method for assessment of color processing mechanism in the human brain using cerebral blood flow velocity monitoring, specifically transcranial Doppler ultrasound. The method including steps of transluminating color discs from a light source of a specific color temperature, which act on the visual pathways and color centers to alter mean blood flow velocity in the cerebral arteries. The mean flow velocity is analyzed and using Fourier computation to calculate spectral density estimates. Opponent mechanism in the cortical and subcortical regions determined as opposing tendency for short wavelength versus medium wavelength or for medium wavelength versus long wavelength colors. The method is applied for diagnosis, and treatment of variety of conditions.

Described is a method for deploying a stent-graft in the aorta, the method including positioning a shunt to go along a portion of a brain-supplying artery (BSA) into the aorta; deploying a stent-graft in the aorta along a portion of the shunt; and removing the shunt. Also described is a removable shunt adapted for deployment along a brain-supplying artery into an aorta to supply blood to the artery during deployment of a stent-graft in the aorta, the removable shunt including a stiff segment that is stiff enough to remain at least partially open when between the aorta and the stent-graft and large enough to allow sufficient blood supply to the brain during the deployment of the stent-graft; and a mechanism for facilitating safe removal of the shunt from between the stent-graft and the aorta. Also described is a method of deploying a branch stent graft having a flaring portion in a blood vessel branching at a bifurcation from an aorta to connect to an aortic stent graft deployed in the aorta across the bifurcation, a branch stent-graft useful in the method, and a delivery system useful in the method.

The invention relates to an amantadine nitrate compound with a neuroprotective effect, and preparation therefor and medical application thereof. The compound has a structure of a general formula (I) as shown in the specification, has multimechanisms, comprises NMDA receptor inhibition, NO releasing and inhibition of inward flow of calcium ions, and has a good protection effect on cells, particularly on neurons. The compound can be used for preparing drugs with a cytoprotection effect, and the drugs are used for preventing or treating diseases related to increasing of NMDA receptors, calcium ions in cells and the like, such as diseases related to neurodegeneration including senile dementia, parkinson's disease, brain stroke, glaucoma and the like, diseases related to a cardio-cerebrovascular system including parkinsonism combined with cerebral arteriosclerosis, and respiratory tract infectivity caused by influenza viruses.

A suction catheter system is described with a suction extension interfaced with a guide catheter to form a continuous suction lumen extending through a portion of the guide catheter and through the suction extension. The suction extension can be positioned by tracking the suction nozzle through a vessel while moving a proximal portion of the suction extension within the lumen of the guide catheter. The suction extension can comprise a connecting section with a non-circular cross section for interfacing with the inner lumen of an engagement section of the guide catheter. The tubular body of the guide catheter can have a reduced diameter distal section the can be useful to restrain the movement of the suction extension. Proximal fittings attached to the guide catheter can facilitate safe removal of the catheter system from the patient by allowing for the removal of some or all of a tubular extension of the suction extension from the guide catheter behind a hemostatic seal. Pressure sensors connected to the proximal fittings can help to guide the procedures with reduced risk of embolizing thrombus.

The present invention provides acetylated derivatives of puerarin that have higher bioavailability and are particularly suitable for oral administration. The present invention also teaches that medicaments made of acetylated puerarin derivatives can be used to treat myocardial ischemia, regulate blood lipids, enlarge coronary and cerebral arteries and cardiovascular systems, reduce oxygen consumption of cardiomyocytes, improve microcirculation and prevent platelets Cohesion.

A Chinese medicine for treating chronic dementia, sanile dementia, vanular dementia and AD is prepared from 7 Chinese-medicinal materials including astragalus root, red sage root, Chuan-xiong rhizome, borneol, etc. Its advantages are high curative effect and quickly taking its effect.

The disclosure relates to an image processing method for estimating a brain shift in a patient, the method involving: the processing of a three-dimensional image of the brain of a patient, acquired before a surgical operation, in order to obtain a reference cerebral arterial tree structure of the patient; the processing of three-dimensional images of the brain of the patient, acquired during the operation, in order to at least partially reconstitute a current cerebral arterial tree structure of the patient; the determination from the combination of the reference and current cerebral arterial tree structures, of a field of shift of the vascular tree representing the shift of the current vascular tree in relation to the reference vascular tree; the application of the determined field of shift of the vascular tree to a biomechanical model of the brain of the patient in order to estimate the brain shift of the patient; and the generation, from the estimated brain shift, of at least one image of the brain of the patient, in which the brain shift is compensated.

Disclosed is a Chinese medicament for treating vertigo which comprises pinellia tuber 12g, dried orange peel 12g, poria cocos wolf 15g, honey-fried licorice root 6g, fresh ginger 9g, smoked plum 3g, kudzuvine root 30g, root of red rooted saliva 15g, riddle 15g, grassleaved sweetflag rhizome, batryticated silkworm each 16g, root of red rooted saliva, peach kernels, safflower, red peony root each 20g, gastrodia tuber, eucommia bark, hooked uncaria, abalone shell each 10g. The Chinese medicament has simplified recipe, easy preparing process and low price.

The invention provides an automatic image processing and displaying method based on a magnetic resonance cerebral perfusion image, which is used for assisting in evaluating cerebral ischemia disease risks and is characterized by comprising spatial deformation, multi-parameterization, brain map coverage and a method for evaluating ischemic cerebral disease risks. The image space deformation methodcomprises the following steps: head movement correction, which is used for adjusting a space difference generated by head movement in a cerebral perfusion imaging process; and standard brain registration: taking the standard brain as a reference to realize standardization of the imported cerebral perfusion image. The multi-parameterization is used for converting the original nuclear magnetic datainto cerebral image perfusion parameters such as cerebral blood flow, cerebral blood volume and artery arrival time, wherein the coverage brain map is used for enabling the parameterized cerebral perfusion image data to cover standard brain maps of different templates to form different regions of interest, and calculating average parameter values of the different regions of interest.The standard cerebral map comprises a cerebral artery blood supply area and an early CT scoring area of an Albetan stroke project. The ischemic brain disease risk assessment method is used for comparing the averageparameter value of the region of interest with a reference range, displaying the differentiation degree and automatically displaying the region of interest beyond the reference range. According to the invention, multi-parameter automatic partitioning and quantitative processing from nuclear magnetic cerebral perfusion original number to ischemic cerebral disease early-stage risk assessment are realized, and an effective assessment method is provided for early-stage screening, early-stage diagnosis and early-stage treatment of cerebral ischemic diseases.

Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, and brain injury are described. More particularly, TNF blocking agents that target TNF-receptor interactions and the effects of downstream secreted cytokines associated with an inflammatory cascade are described. Such TNF blocking agents are administered directly to the brain by, for example, intraparenchymal administration, intracerebroventricular administration, or administration into a cerebral artery. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject.

The invention discloses a body-building syrup, which is prepared from gen-seng, gastrodia tuber, Siberian solomonseal rhizome, Moruloidea, asparagus root, lilyturf root, achyranthes and cyathula root, wolferry fruit, prepared rhizome of rehmannia, dried rehmannia root, haw, rhizoma dioscoreae and bee honey through boiling, filtering and concentrating.

A flow diverter for implantation into a patient's vessel includes a distal annular support element and a proximal annular support element, the proximal and distal support elements supporting a longitudinally twisted diverter element. The flow diverter is designed to be disposed within a vessel and to impart a rotational or twisting motion to the flow of blood passing therethrough, thereby to reduce the pressure of blood at the center of the vessel. Such flow diversion can reduce the pressure of blood impinging upon an aneurysm at a bifurcation downstream of the vessel. The device can be particularly useful for the treatment of aneurysms occurring at the bifurcation between the basilar artery and the posterior cerebral arteries.