113 results about "Cytoprotection" patented technology

This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula:

This invention comprises administering to a human or animal in need of treatment an effective amount of an antioxidant lipoic acid derivative and / or pharmaceutically acceptable salts and solvates thereof for the treatment or prevention of pathological (inflammatory, proliferative and degenerative diseases, e.g. diabetes mellitus, atherosclerosis, Alzheimer's disease and chronic viral diseases) and non-pathological (e.g. skin aging and wrinkle formation) conditions caused by oxidative damage. Methods of synthesizing novel antioxidant lipoic acid derivatives and their use in preventing or treating diseases or conditions caused by oxidative stress and other free radical mediated conditions are described. Another aspect of this invention is the use of these antioxidant compositions for the protection of skin from damage caused by ultraviolet radiation and dessication, and to provide improved skin feel by desquamating, cleansing and clarifying the skin. The compositions described in this invention increase cellular viability of epidermal cells, promote cytoprotection, and decrease the production of inflammatory mediators such as inflammatory cytokines in these cells. The antioxidant compositions are incorporated into sunscreen products, soap, moisturizing lotions, skin toners, and other skin care products.

In alternative embodiments, this invention provides compositions and methods for treating cancer or any condition caused by dysfunctional cells, side effects from treatments for cancer or any condition caused by dysfunctional cells, e.g., mucositis therapies (e.g., for oral mucositis; digestive mucositis; esophageal mucositis; intestinal mucositis). In alternative embodiments, the invention provides cytoprotection products that may be used either alone or in combination with other medical therapies such as cancer chemotherapies and radiation therapies.

A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the proteins candidates for therapies in inflammatory bowel disease, mucositis, and gastric ulcers.

The invention relates to pyrazine derivatives, a preparation method therefor and medical application thereof. The pyrazine derivatives can be used for scavenging free radicals and inhibiting calcium ions from being overloaded, play a role in protecting cells and can be used for preventing or treating related diseases such as cardiovascular and cerebrovascular diseases, neurodegenerative diseases and the like.

The present invention relates to antifibrillogenic agents for inhibiting amyloidosis and / or for cytoprotection for the treatment of amyloidosis disorders. These agents include peptides, isomers thereof and peptidomimetic compounds thereof. These agents comprise a peptide having a sequence identified from the glycosaminoglycan (GAG) binding region and the prot-prot interaction region of the amyloid protein. The peptide has at least one [D] amino acid isomer substitution. The invention also relates to the peptide bound to a label for in vivo imaging of amyloid deposits.

A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the proteins candidates for therapies in inflammatory bowel disease, mucositis, and gastric ulcers.

Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial infarction, myocardial ischemia, chronic heart failure, inflammation and other oxidative stress-related conditions, as well as Alzheimer's disease and senile dementia; they are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

The invention relates to the technical field of natural medicine medicinal chemistry and medicines, provides an isoflavone compound, and particularly relates to a novel use for five compounds including iridin (BC1), tectorigenin (BC2), tectorigenin-4'- heteroside (BC3), irigenin (BC4) and tectoridin (BC5). A model experiment that ultraviolet rays irradiate a mouse to cause skin injury is performed, results show that the BC1, the BC2, the BC3, the BC4 and the BC5 can remarkably improve skin pathology caused by ultraviolet irradiation, for example, skin cutin apoptosis caused by ultraviolet irradiation can be suppressed remarkably, and a remarkable cell protection function is showed; inflammatory response of injured skin tissues after ultraviolet irradiation can be remarkably suppressed; and oxidative damage of homogenate of the injured skin tissues after ultraviolet irradiation can be relieved remarkably. The belamcanda chinensis isoflavone compound can be used for preparing medicines for preventing and curing skin injury caused by the ultraviolet rays.

Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I):including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein.

Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.1 can result in lowering of blood glucose levels and may reducing insulin resistance, the compositions, methods and cells described herein can also be used for treating Type 2 diabetes (T2D).

The present invention relates to a biopolymer composition for encapsulating cells, containing alginate, at least one glycosaminoglycan compound, preferably chondroitin sulfate, and at least one component of the extracellular matrix, preferably laminin, and to the process for producing the biopolymer composition. Also disclosed are a method for promoting cytoprotection using this composition, and the use of this composition for preparing a medicament useful in cell transplantation.

The invention discloses a pharmaceutical composition containing interferon and an application. Pharmacologically active ingredients of the pharmaceutical composition are the interferon and taurine, wherein an activity unit content of the interferon is 10 to 1x10<6> IU / mL, and a content of the taurine is 0.05-0.5 mg / ml. The pharmaceutical composition containing the interferon provided by the invention has effects of resisting activity of vesicular stomatitis virus and murine encephalomyocarditis virus, and protecting cells. Especially, each of nasal spray agent provided by the invention only has 50000 IU of alpha-2b recombinant human interferon and 1 mg of the taurine, but has a specific anti-viral activity of 9.15x10<5> to 2.8x10<6> IU, and shows substantial synergistic effect, thereby being significant for improving patient compliance and reducing medication costs, and meeting clinical needs of interferon medications.

This invention relates to the 5-cis and 5-trans isomers of geranylgeranyl acetone, preferably such synthetic isomers, and pharmaceutical compositions containing such isomers. Other aspects of this invention relate to the use of geranylgeranyl acetone and its isomers in methods for inhibiting neural death, increasing neural activity, and increasing axon growth and cell viability. Geranylgeranyl acetone is a known anti-ulcer drug used commercially and in clinical situations. GGA has also been shown to exert cytoprotective effects on a variety of organs, such as the eye, brain, and heart.

The invention relates to a nano-material cell-based biosensor, a preparation method thereof and a new method using the nano-material cell-based biosensor to evaluate the antioxidant activity of antioxidant polypeptides and relates to the field of antioxidant capacity measuring. Colonic adenocarcinoma cells are used as the sensing elements to build a cell gel three-dimensional network structure, and the cell gel three-dimensional network structure is combined with nano-material modification electrodes to evaluate the antioxidant activity of the polypeptides. The method using the cells to simulate electrochemical signals so as to evaluate the antioxidant activity of the polypeptides is novel and convenient in detection and has high practicality in the comprehensive evaluation of the cell protection effect of antioxidant substances.