34 results about "Gastric antrum" patented technology

A semi-stationary balloon in the gastric antrum provided with an anchoring rod for inducing weight reduction in human beings is disclosed, a device for inducing a lesser appetite and early prandial satiety, said balloon being made of inflatable per-os medical grade silicone having a volume of up to 240 ml, with an average space of 120 ml to be filled with non-elastic fluid provided with radio-opaque contrast and dye, preferably methylene blue, so that the maximum diameter of 8 cm is reached after it is filled up with a volume of up to 240 ml and the average diameter of 6 cm with a volume of 120 ml, to be endoscopically placed inside the stomach (E); said intra-gastric balloon (1) being positioned in a semi-stationary way in the gastric antrum (GAC) and provided with an anchoring or duodenal rod (2) having a distal counter-weight (5) installed in the duodenum (D); particularly, the inner face of the pear-shaped medium portion of lesser diameter is coated with a malleable ribbon (f) that provides said balloon (1) with resistance and flexibility.

The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and / or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.

The teachings are directed to an intragastric device comprising a flexible and expandable bladder having a predetermined shape upon expansion for contacting the antrum of the stomach of a subject. The device is designed to avoid passage of any part of the device beyond the pylorus and lower esophageal sphincter while the bladder is expanded during use. In these embodiments, the bladder can contain a high specific gravity material when expanded; wherein, the high specific gravity material contributes to an in vivo specific gravity of the device that ranges from about 1.2 g / ml to about 2.1 g / ml and functions to direct the device to the pyloric antrum of the subject during use of the device. Moreover, these embodiments can include a filling material comprising a biocompatible fluid component and a hydrogel component to make the device substantially leakproof and contribute to the in vivo specific gravity of the device.

A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the proteins candidates for therapies in inflammatory bowel disease, mucositis, and gastric ulcers.

The invention discloses novel application of a plaster preparation prepared by a pharmaceutical composition in treating infantile anorexia and indigestion. The plaster preparation is a pure Chinese medicinal preparation of a classic formulation for treating infantile diarrhea, and the plaster consists of flos caryophyllata, cortex cinnamoni, and fructus piperis longi. A clinic trial and pharmacodynamic experiment research proves that the novel application of the plaster. Treatment on the infantile anorexia mainly comprises improving the pepsin activity in intestinal canal of the body, and treatment on the infantile digestion mainly comprises the following steps: reducing the amount of mast cells of a gastric antrum, reducing the content of nitric oxide in serum, increasing the content of cholinesterase in the serum, accelerating gastric emptying and inhibiting intestinal peristalsis.

The invention relates to a multifunctional balloon catheter integrated with a puncture needle and a system. The balloon catheter adopting unique design and the system can be used for different types of tumor such as benign and malignant bile duct stenosis, esophagus cancer, colorectal cancer, bronchogenic carcinoma, gastric antrum cancer, portal vein and vena cava tumor thrombus of primary hepatic carcinoma and the like, a far-end part where an eccentric balloon and the puncture needle are located is precisely put in the part where tumor of a lumen is located, a swelling balloon pushes the far end of the puncture needle to attach to the tumor, a near end of a rotating system operates a nut of the system and pushes the puncture needle to extend out of the catheter, the far end of the puncture needle with shape memory is bent and punctures the tumor, the puncture needle can be used for injecting a tumor treatment drug into the tumor to treat tumor or sucking tissue for biopsy or is used as a radiofrequency ablation electrode to perform radiofrequency ablation / heating to treat the tumor; on the basis of the system, with the adoption of different designs, the multifunctional balloon catheter can be used for injection of the treatment drug into atherosclerosis plaques and treatment of aortic dissecting aneurysm.

The invention discloses a novel application of gastrin in inhibiting gastrointestinal tumor tumors. Gastric cancer target gene anion exchange protein 1 is interacted with tumor suppressor protein p16 so as to induce gastric cancer, however, 17 peptide gastrin (H-pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) can effectively inhibit expression of gastric cancer target gene AE1 and p16 and breaks through the traditional view that gastrin induces tumors, and clinical pathologies show that the gastrin has obvious negative correlation with AE1 and p16. The invention alsodiscloses that the gastrin with the concentration of 10-10mol / L-10-70mol / L has obvious inhibition effect on gastric cancer cell activity after a certain time, thus prompting that the gastrin has curing effect on gastric antrum cancer and providing a new direction for curing gastric cancer based on the test results.

The invention discloses a traditional Chinese medicine preparation for assisting acupuncture treatment of diabetic gastroparesis and a preparation method and applications thereof. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 8-10 parts of astragalus membranaceus, 8-10 parts of codonopsis pilosula, 8-10 parts of atractylodes macrocephala koidz, 3-6 parts of fructus amomi, 6-8 parts of hovenia dulcis, 6-8 parts of salvia miltiorrhiza and 6-8 parts of endothelium corneum gigeriae galli. The traditional Chinese medicine preparation is prepared by decocting raw herbal materials with water, then extracting and concentrating. Pharmacodynamic experiments show that the traditional Chinese medicine preparation for assisting acupuncture treatment of diabetic gastroparesis has no obvious adverse reaction, and is safe and reliable; the preparation can be used for promoting the increase of body mass, food intake and stool quantity of mice with diabetic gastroparesis, relieving the gastric electrical activity confusion and improving the gastric antrum ICC ultrastructure very well, so that the expression of positive ICC and SP positive materials of gastric antrum c-kit can be enhanced, and the positive expression of nNOS can be lowered; and the preparation has a good improvement effect on the number increasing, form and signal transduction function of ICC.

The invention discloses an external drainage tube for nasal-gallbladder bile. An elastic loop tube I, an elastic loop tube II, a drainage tube segmentI, a drainage tube segment II, a drainage tube segment III, a drainage tube segment IV are arranged from the top to the bottom successively and communicated with each other. The drainage tube segment I is similarlyin an arc shape, and the arc shape opens towards the elastic loop tube I. The drainage tube segment II is curved, and forms a sigma shape with an end of an arc tube segmentII. The drainage tube segment III is in an arc shape, and the arc shape opens towards an arc tube segment I. The drainage tube segment IV is in a straight line shape. The end part of the elastic loop tube I, elastic loop tube II and arc tube segment II are all provided with bile drainage orifices. The external drainage tube for the nasal-gallbladder bile has five bends, which is conformed to the five physiological bends of a gallbladder cavity (the elastic loop tube I, the elastic loop tube II), a gallbladder tube-a common bile duct (the drainage tube segmentI), the common bile duct-a duodenum (the front part of the drainage tube segment II), the duodenum-a gastric antrum (end part of the drainage tube segment II), a greater curvature of stomach (the drainage tube segment III). The external drainage tube for the nasal-gallbladder bile is good in comfort.

The invention discloses a rat stomach antrum pressure sensor probe which comprises an elastic saccule, an upper catheter, a lower catheter, a tee joint, an injector and a pressure transducer. The two ends of the upper catheter are connected with the elastic saccule and the upper end of the tee joint respectively. The two ends of the lower catheter are connected the lower end of the tee joint and the pressure transducer. A horizontal through opening of the tee joint is connected with the injector. The elastic saccule is a condom front section air bag. A probe structure is greatly simplified, and the back end platform requirement is lowered. The structure is simplified, storing is easy, manufacturing can be carried out through a condom and the injector by a user, and related experiment cost is saved.

The invention provides a ligand antrum mucosal protein-18(AMP-18) of a laminin receptor (LR), which has an amino acid sequence as shown in SEQ ID No.1 in a sequence table. The ligand antrum mucosal protein-18(AMP-18) can bind with LR on the surface of gastric epithelial cells to inhibit the growth of stomach cancer cells and can be used to prepare drugs for treating tumor.

The invention discloses a rotatable scraper spoon used under an endoscope. The rotatable scraper spoon comprises a first handle and a sliding handle slidably arranged on the first handle, wherein a sheath tube is arranged at the front end of the first handle; a mandrel penetrates through the sheath tube and can move back and forth in the sheath tube; one end of the mandrel is connected with the sliding handle; a scraper spoon is fixed at the other end of the mandrel; and the scraper spoon is driven to extend out and retract from the front end of the sheath tube by moving the sliding handle back and forth. The sliding handle is pushed and pulled to drive the mandrel to move back and forth, then the mandrel drives the scraper spoon to move back and forth to get gastric juice by scraping, andafter the gastric juice is scraped by the scraper spoon, the sliding handle is pulled to move backwards to enable the scraper spoon to extend into the sheath tube. The inner wall of the sheath tube can exert a certain sealing effect on the gastric juice in the scraper spoon, so that the gastric juice in the scraper spoon is prevented from leaking out and flowing into a digestive tract, and then the functions of extracting gastric juice on a gastric antrum and a gastric body and collecting the gastric juice and tissues under an endoscope are further realized.

The invention discloses a method for determining an area, an ultrasonic device and a computer storage medium. The method for determining the area based on the ultrasonic image comprises the following steps: emitting an ultrasonic beam to a target object including a gastric antrum region by exciting an ultrasonic probe, and receiving an ultrasonic echo returned from the target object through the ultrasonic probe to obtain an ultrasonic echo signal; the processor processes the ultrasonic echo signal to obtain an ultrasonic image of the target object; the processor determines a measurement frame image based on the ultrasonic image; and the processor determines the antral region of the target object in the measurement frame image and further determines the area of the antral region. Therefore, in the embodiment of the invention, the ultrasonic image is processed and analyzed by the processor, so that the area of the antral region of the target object is obtained, manual selection of a user according to experience is omitted, and on one hand, the mode saves time and labor and is higher in efficiency; and on the other hand, the method does not depend on user behaviors, and the determined area is more accurate.

The invention relates to a traditional Chinese medicine composition for treating child anorexia and a preparation method of the traditional Chinese medicine composition for treating child anorexia. The traditional Chinese medicine composition is prepared from 12 kinds of raw material medicine materials of radix codonopsis, bighead atractylodes rhizomes, radix ophiopogonis, polygonatum odoratum, herba dendrobii, haws, white peony roots, dried orange peel, Chinese yams, endothelium corneum gigeriae galli, striga asiatica and licorice roots through technologies of performing pretreatment, performing decoction, performing ethanol precipitation, performing concentration, performing drying and the like. The traditional Chinese medicine composition has the efficacy of benefitting qi, invigoratingthe spleen, nourishing yin, nourishing the stomach and resolving food stagnation, and is used for diseases of anorexia or apastia caused by infantile deficiency and weakness of spleen qi and defectsof stomach yin, lack of lustre in complexion, loss of spirit, emaciated or puffy bodies, easiness to sweat, loose stool or constipation, or retention of food and drink, abdominal fullness and distention and the like. The animal experiment result indicates that the traditional Chinese medicine composition disclosed by the invention can increase the food intake of an anorexia model bandicoot, can promote secretion of gastrin of the gastric antrum part, can achieve the effect of treating both manifestation and root cause of the child anorexia, and has great broad market development prospects.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents (TA) within the GI tract and in particular to an antrum wall (AW). Particular embodiments provide a swallowable device (SD) such as a capsule for delivering drugs or other TA into the AW. The SD may contain a pressure sensitive component or assembly which triggers release and insertion of a therapeutic agent preparation (TAP) comprising at least one TA into the AW in response to external pressure, such as pressure applied to the swallowable capsule or other SD by antrum contractions. Particular embodiments of the SD may be shaped so that they self-align within an antrum to properly orient before injection of the TAP into the AW. Embodiments of the invention are particularly useful for orally delivering drugs or other TAs which are degraded within the GI tract and require parenteral injection.

The invention provides an esomeprazole sodium composition for injection, relating to the field of drugs and drug production technology. The main drug of the composition includes esomeprazole sodium and melatonin, wherein the melatonin comprises a quick release part and a cyclodextrin-inclusion slow release part. The esomeprazole sodium composition for injection is fast in potency and reliable in effect, and applicable to a patient who is not suitable for orally taking medicine, and a drug which is not suitably taken orally; the drug administration design of combining quick release and slow release meets the physiological secretion characteristic of the melatonin, solves the defect of short half life period of the melatonin, and improves the bioavailability of the product; the synergism of the esomeprazole sodium on treating reflux esophagitis can be achieved, gastric dynamics can be enhanced to promote gastric emptying. The coordinated movement of stomach antrum, pylorus and duodenum can be promoted, and the reflux of gastric content can be completely prevented.

The invention provides a separation and culturing method of gastric antrum interstitial cells of SD (Sprague Dawley) rats. The separation and culturing method comprises the following steps: selecting4-5-week-old SD rats as elementary bodies; stripping gastric antrum tissues, and performing centrifugal operation under the effect of II-type collagenase and separating out ICC cells; performing culturing in an M199 complete culture medium, and then performing digestion operation and centrifugation treatment to obtain the separated ICC cells. According to the method disclosed by the invention, byusing the 4-5-week-old SD rats (110 plus / minus 10g) as an experimental animal, the defect of low cell acquisition ratio caused by highly differentiation of the ICC cells of adult rats is avoided; meanwhile, according to the separation and culturing method disclosed by the invention, the concentration of the II-type collagenase is adjusted, and damage of low-concentration long-time digestion or high-concentration short-time digestion on cells is avoided; purification is carried out by adopting the principles of cell contact inhibition and advantage competition, so that the damage of gradient centrifugation on the fragile cells is avoided.

The invention discloses a bionic stomach, a preparation method thereof and an application thereof, belonging to the bionic technology field and the biotechnology field. The biomimetic stomach of the invention is prepared by mixing a base material (one or more of silica gel, emulsion or hydrogel) and auxiliary materials (silicone oil and curing agent) according to a certain mass ratio, and applyingthe mixture to the fundus of stomach, stomach body and gastric antrum of a precise human gastric anatomy model of the medical digestive department. The bionic stomach of the invention has superior simulation performance, and has a real physiological structure of a real human stomach inner wall, can realize the function of grinding food by the stomach, and has extremely strong consistency in performance, structure and function with the real human stomach. The bionic stomach of the invention separates the bionic gastric antrum and the gastric body, respectively applies a certain pressure to theseparated gastric antrum and the gastric body, thereby realizing the back jet function between the gastric body and the gastric antrum, and therefore, the bionic stomach of the invention has a greatapplication prospect in the research process of foods and medicines.

The invention discloses a method for verifying the effectiveness of inhibition effect of health wine on helicobacter pylori. The method specifically comprises the following steps: preparing a helicobacter pylori strain and experimental mice; grouping the experimental mice; carrying out bacterial culture and animal modeling; dosing the grouped mice; performing model detection and model replication evaluation; performing physical sign observation on the mice; dissecting the mice, carrying out general morphological observation on the stomachs of the mice, carrying out urease detection on gastric antrum mucosa tissue, and carrying out gastric histopathologic HE staining and hepatic histopathologic HE staining; and judging the effectiveness of the inhibition effect of the health wine on the helicobacter pylori according to a sign observation result, a stomach general morphological observation result, a gastric sinus mucosa tissue urease detection result, an observation result after gastric histopathologic HE staining and an observation result after hepatic histopathologic HE staining. The verification method can be used for scientifically, effectively and comprehensively verifying the helicobacter pylori inhibition effect of the health wine.

The present invention discloses a new usage of a preparation of agastachis for restoring health, in particular to the usage of the preparation of agastachis for restoring health in the preparation of the drugs for lowering the vasoactive intestinal peptide. More particularly, the present invention is the application of the preparation of agastachis for restoring health in the preparation of the drugs for lowering the vasoactive intestinal peptide in the plasma; the application in the preparation of the drugs for lowering the vasoactive intestinal peptide in the gastric antrum tissue homogenate; the application in the preparation of the drugs for lowering the vasoactive intestinal peptide in the jejunum tissue homogenate; the application in the preparation of the drugs for lowing the vasoactive intestinal peptide positive products in the gastric antrum, jejunum mucosa and myenteric plexus; and the application in the preparation of the drugs for lowering vasoactive intestinal peptide and promoting gastric motility. The pharmacological studies show that the preparation of agastachis for restoring health can reduce the release of vasoactive intestinal peptide and promote the gastric motility.

A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Control of mammalian gastro-intestinal tissues growth and repair is facilitated by the use of the proteins, making the proteins candidates for therapies.

The invention relates to a traditional Chinese medicine composition for treating chronic atrophic gastritis. The traditional Chinese medicine composition is composed of raw radix astragalis, roasted rhizoma atractylodis macrocephalae, poria, processed rhizoma pinelliae, radix bupleuri, curcuma zedoary, radix curcumae, grilled hedgehog skin, Japanese ardisia, parched white peony root, the rhizome of Chinese goldthread, tetradium ruticarpum, hedyotis diffusa, and raw oyster. According to the traditional Chinese medicine composition for treating chronic atrophic gastritis, in the aspect of a method for treating chronic atrophic gastritis, what is emphasized is that both the primary and secondary symptoms should be treated, the chosen drug ought to eliminate phlegm and do not harm the body, remove blood stasis and do not influence blood, stop bleeding and do not leave stasis, and the functions of strengthening spleen and eliminating phlegm, promoting qi and dispersing stagnation, removing necrotic tissue and promoting granulation, and softening hardness to dissipate stagnation are achieved simultaneously. Through the application of the traditional Chinese medicine composition, the course of the treatment is shortened, and the traditional Chinese medicine composition has no obvious toxic and side effects. The traditional Chinese medicine composition can obviously and quickly improve clinical symptoms, the symptoms can be quickly relieved in a short time, the antrum pathology result and the expression of partial immunohistochemistry indexes are quickly improved, the restoration of gastric mucosa is promoted, and the course of the treatment is shortened; through the application of the traditional Chinese medicine composition, the shortcomings of western medicine in treating chronic atrophic gastritis are made up, the treatment cost is saved, and thus the chronic atrophic gastritis is worth applying and popularizing.

The invention discloses a novel application of gastrin in inhibiting gastrointestinal tumor tumors. Gastric cancer target gene anion exchange protein 1 is interacted with tumor suppressor protein p16 so as to induce gastric cancer, however, 17 peptide gastrin (H-pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) can effectively inhibit expression of gastric cancer target gene AE1 and p16 and breaks through the traditional view that gastrin induces tumors, and clinical pathologies show that the gastrin has obvious negative correlation with AE1 and p16. The invention alsodiscloses that the gastrin with the concentration of 10-10mol / L-10-70mol / L has obvious inhibition effect on gastric cancer cell activity after a certain time, thus prompting that the gastrin has curing effect on gastric antrum cancer and providing a new direction for curing gastric cancer based on the test results.

The invention belongs to the technical field of medicine and particularly relates to a traditional Chinese medicine composition for treating residual gastric antrum syndrome. The traditional Chinese medicine composition is prepared from, by weight, 16-24 parts of starfish, 6-14 parts of red screw towers, 16-24 parts of calanthe discolor lindl, 6-14 parts of balanophora laxiflora, 6-14 parts of Chinese alpine rush, 6-14 parts of dolomiaea berardioidea, 6-14 parts of twisted-stalk, 6-14 parts of radix sophorae flavescentis, 6-14 parts of osmanthus dew, 6-14 parts of clove smartweed roots and 11-19 parts of sea crabs. The ingredients are combined and have the effects of relieving liver for smoothing Qi, strengthening the spleen and the stomach, promoting Qi to activate blood and producing acid and calming the adverse-rising energy, and the total effective rate is as high as 98.72%.

The invention aims at preparing a hybrid tumor of an anti-antrum mucosalprotein-18 (AMP-18) monoclonal antibody and relates to application thereof in preparing a tumor clinical detection reagent. Particularly, in the invention, a hybrid tumor cell (70110-4) capable of secreting the monoclonal antibody specifically recognizing the AMP-18 is screened through a molecular cloning technology and a monoclonal antibody technology. The monoclonal antibody secreted by the 70110-4 can be used for the clinical detection of carcinoma lesion in gastric tissues of human bodies.

The invention discloses a nasal gallbladder bile drainage catheter with an expansile saccule, wherein an elastic loop pipeI, an elastic loop pipe II, a drainage pipe segment I, a drainage pipe segmentII, a drainage pipe segment III, and a drainage pipe segment IV are interconnected and arranged on the nasal gallbladder bile drainage catheter from stem to stern. The drainage pipe segment I is shaped arc-like, and the arc opens towards the elastic loop pipe I. The drainage pipe segment II is shaped curved and forms a 'Sigma' shape with the final segment of an arc pipe segment II. The drainage pipe segment III is arc-shaped, and the arc opens towards an arc pipe segment I. The drainage pipe segment IV is shaped like a straight line. Bile drainage orifices are arranged on the elastic loop pipe I, the elastic loop pipe II, and the final segment of the arc pipe segment II. A saccule is arranged on the exterior wall of the head segment of the arc pipe segment II. The nasal gallbladder bile drainage catheter with the expansile saccule involves five curves, conforms to five physiological curves including gallbladder cavity, gallbladder duct to common bile duct, common bile duct to duodenum, duodenum to gastric antrum, greater gastric curvature, and has a good comfort level.

The invention relates to a gastrointestinal implant (17) comprising a tubular element (1), designed to feed chyme through at least one section of the human intestine; a first fastening means (3) connected to the tubular element (1), having a first support surface (33), and designed to be positioned in a section of the duodenum (2) adjacent to the pylorus (7); a second fastening means (4) connected to the tubular element (1) or to the first fastening means (3), having a second support surface (34), and designed to be positioned in the antrum (5) of the stomach; a connection element (6), which connects the first fastening means (3) or the tubular element (1) to the second fastening means (4), the connection element (6) being designed such that when the first fastening means (3) is in the position in the duodenum (2) and the second fastening means (4) is in the position in the antrum (5) of the stomach, the first and second fastening means are pressed against each other with the pylorus (7) therebetween by the first support surface (33) of the first fastening means and the second support surface (34) of the second fastening means, without the fastening means (3,4) being lifted from the pylorus.