The invention relates to a dry suspension of sodium dexlansoprazole and a preparation method of the dry suspension. The dry suspension is prepared from a new crystal form A of sodium dexlansoprazole, sodium bicarbonate, a solubilizer, gastric-soluble quick-release pellets A, enteric sustained-release pellets B, filler, a suspending agent, a flavoring agent and other pharmaceutically acceptable auxiliary materials, wherein the gastric-soluble quick-release pellets A are prepared by coating quick-release pellet cores A prepared from a raw material, namely, the new crystal form A of sodium dexlansoprazole with gastric-soluble coats, and the enteric sustained-release pellets B are prepared by coating slow-release pellet cores B prepared from a raw material, namely, the new crystal form A of sodium dexlansoprazole with enteric coats; the rest new crystal form A of sodium dexlansoprazole is supplemented by sodium bicarbonate and the solubilizer for micronization pretreatment. The dry suspension is moderately released in the stomach and can quickly relieve excessive gastric acid, stomachache and other symptoms, residual medicines are slowly dissolved and released in intestinal tracts, and the efficacy is prolonged. Meanwhile, the dry suspension has the advantages that the dry suspension tastes good, dissolves out quickly, is convenient to take, can improve patient compliance and the like, the preparation process is advanced, simple to operate, safe, pollution-free and suitable for industrial production.