The invention relates to the technical field of pesticides, and particularly provides a pest and disease resistant composition containing hypersensitive protein, which comprises an active component Aand an active component B, wherein the active component A comprises Harpin protein; the active component B is selected from: amino-oligosaccharin, lentinan, nitenpyram, pymetrozine, imidacloprid, acetamiprid, dicyclanil, ethiprole, butene-fipronil, mandipropamid, fluopicolide, boscalid, fluopyram, tebuconazole, epoxiconazole, cyproconazole, tetraconazole, difenoconazole, hexaconazole, flutriafol,prothioconazole, penconazole, myclobutanil, flusilazole, propiconazole, pyraclostrobin, garlicin, and ethylicin, wherein the weight ratio of the active component A to the active component B is 100:1- 1:100; wherein the amino-oligosaccharin comprises amino-oligosaccharin with high molecular weight and amino-oligosaccharin with low molecular weight.