The invention discloses a sterilization composition containing fluopicolide and methoxyl acrylic acid ester compounds, in particular a sterilization composition containing an active ingredient A and an active ingredient B, wherein the active ingredient A is selected from fluopicolide; the active ingredient B is selected from any one fungicide of phenylate oxystrobin andpyraclostrobin; furthermore, the weight ratio of the active ingredient A to the active ingredient B is 60:1 to 1:60. The composition disclosed by the invention is capable of controlling a plurality of crop diseases and has obvious synergism; furthermore, the fungicide spectrum is enlarged; the sterilization composition has higher activity on diseases, such as powdery mildew, downy mildew, anthracnose, rust disease, epidemic disease, apple scab, calico, damping off, and the like; in addition, the pesticide use amount is reduced; the residual quantity of pesticide on crops is reduced; and the environmental pollution is lightened.