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Water surface floated sustained-release medicament for preventing and treating blood fluke and method for preparing the same

A technology of floating on the water surface and schistosomiasis, which is applied in the direction of botany equipment and methods, applications, biocides, etc., can solve the problem of difficult to achieve targeted drug delivery, and achieve the effect of convenient application, long drug effect and strong lethality

Inactive Publication Date: 2008-07-09
范小林 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since Oncomelania usually inhabits near the water surface, it is difficult to achieve the purpose of targeted drug delivery by conventional methods.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] The corn cob is pulverized into particles with a particle size of 0.5-2.0 mm, and then 100 g is taken as a carrier, soaked in 100 ml of paraffin / cyclohexane solution with a concentration of 2.0 wt % for 120 hours, and then taken out. After fully drying, spray with niclosamide / pyridine solution with a concentration of 50.0wt%, spray again after drying, spray repeatedly 10 times, and dry, the content of the active ingredient in the granule can reach about 35 grams. Spray and coat with a chitin solution with a concentration of 10.0 wt%, and after forming a uniform coating with a thickness of 30-50 microns on the outer surface of the medicine particles, take it out and dry it in the air. Finally, the surface is modified by spraying with an aqueous solution of sodium lauryl sulfate with a concentration of 5.0 wt%. After drying, the water surface self-diffusion floating sustained-release medicament can be obtained.

Embodiment 2

[0009] The clean waste wood is pulverized into fine particles with a particle size of 0.05-0.5 mm, then 100 g is taken as a carrier, put into 100 ml of asphalt / xylene solution with a concentration of 5.0 wt%, soaked for 2 hours, and taken out. After being fully dried, spray with a 10.0wt% methyl ether solution, spray again after drying, repeat spraying 5 times, and dry, the content of the drug active ingredient in the granules can reach about 10 grams. Spray and coat with a polyvinyl alcohol solution with a concentration of 5.0 wt%, and after a uniform coating with a thickness of 10-30 microns is formed on the outer surface of the medicine particle, take it out and dry it in the air. Finally, it is sprayed with an aqueous solution of sodium dodecylbenzenesulfonate at a concentration of 2.0 wt % to carry out surface modification. After drying, you can.

Embodiment 3

[0011] The polystyrene foam is crushed into particles with a particle size of 1.0-10.0 mm with a pulverizer, and then 100 grams are taken as a carrier, and the praziquantel solution with a concentration of 30.0 wt% is used to spray evenly, and then spray after drying, and spray repeatedly 10 times, dry it, and the content of the drug active ingredient in the medicine grain can reach about 50 grams. Spray and coat with a modified chitin solution with a concentration of 30.0 wt%, and after forming a uniform coating with a thickness of 50-100 microns on the outer surface of the medicine particles, take it out and dry it in the air. Finally, it is sprayed with a 30.0wt% aqueous solution of Tuwin-21 for surface modification. After drying, the water surface self-diffusion floating sustained-release medicament can be obtained.

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PUM

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Abstract

The invention provides a water surface floatation sustained release medicament for prevention and cure of schistosomiasis, which is a granular sustained release medicament prepared from medicinal active constituent 5.0-60 wt%, solid state carrier material 30.0-90.0wt%, dispersing agent 0.1-10.0 wt%, coating agent 2.0-10.0 wt%, and hydrophobing agent 0.1-5.0 wt%.

Description

technical field [0001] The invention discloses a water surface floating sustained-release medicament for preventing and treating schistosomiasis and a preparation method thereof. The preparation method of the medicament is relatively simple. The application is convenient and the efficacy is long. When spraying the medicine, you only need to sprinkle the medicine into the water surface according to the dosage, and the medicine particles can quickly and evenly spread on the water surface, and float on the water surface for a long time. film of drug molecules. The drug molecular film has strong lethality to the cercariae or miracidia of the schistosome, and can effectively prevent and treat the schistosomiasis. The medicinal preparation is suitable for both manual spraying and large-area aircraft spraying, and is especially suitable for the prevention and treatment of schistosomiasis in deep water areas or floods. Background technique [0002] The prevention and control of s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/00
Inventor 范小林龚子方范文峰
Owner 范小林
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