The invention discloses a sintered shale micropore honeycomb glaze building block and a manufacturing method thereof. The manufacturing method includes: stirring and mixing raw materials comprising shale, building spoil, sludge, rubbish, straw (such as tree branches, leaves, rotten wood or tree), coal gangue, water, and the like to obtain a viscous mixture, extruding and forming to obtain a workblank of the building block, coating at least one side surface of the workblank of the building block with a clay layer and a glaze layer, sintering and forming. The building brick is manufactured by the method. The building block and the manufacturing method have advantages of low cost, short production period, low energy consumption, high building block strength, light unit weight, low heat conductivity coefficient, and good energy-conservation, heat insulation, sound insulation effects. The building block is provided with the glaze layer and can be directly used as a wall surface, thus shortening the building period, reducing cement consumption, reducing environment pollution, and avoiding hazards of dropping of external tiles. In addition, the building block and the manufacturing method achieve processing of the agriculture straw, the coal gangue, the rubbish, and other waste and turn the waste into things of value, thus achieving effects of energy conservation and environmental protection.