30results about How to "Target-specific" patented technology

The invention, relating to the technical field of medical use, particularly relates to a living molecular imaging method and a targeting molecular imaging probe. The living molecular imaging method is characterized by introducing the targeting molecular imaging probe capable of being detected by an imaging device to reflect biochemical change characteristics of connexin protein 43 (Cx43) of cardiovascular diseases (especially arrhythmia), tumor and the like in the form of images, and has accurate detection results. According to the invention, the distribution and amount of the Cx43 can be displayed visually, and the method can be directly applied to human body. The Cx43 targeting molecular imaging probe disclosed herein comprises a signal component, a Cx43 targeting compatible component and a connector, and has good pharmacokinetic characteristics and biological distribution characteristics.

The invention discloses a compound herbicide for preventing and removing ligularia virgaurea as well as a preparation method and an application method thereof. The compound herbicide is composed of the following raw materials in percentage by weight: 2%-40% of tribenuron-methyl, 5%-40% of clopyralid, 40%-90% of bentazone and the balance being auxiliary agents. The preparation method of the compound herbicide comprises the following steps: adding the tribenuron-methyl, the bentazone and the clopyralid, which are weighed according to the weight ratio, into an agitator; adding 5L-20L of tap water and agitating uniformly at a low speed; then adding sodium dodecyl benzene sulfonate, alkylphenol polyoxyethylene and polytrisiloxane according to the weight ratio; sufficiently agitating and uniformly mixing; and filling bottles and sealing. The application method of the compound herbicide comprises the step of spraying the compound herbicide on stems and leaves of ligularia virgaurea at a flowering period, wherein the herbicide spraying amount is 750-3000 g / hectare. The compound herbicide has high selectivity, special target and obvious prevention and removing effects on the specific plant, ligularia virgaurea, has a good ecological effect and can protect the biological diversity of grass lands very well.

The invention provides a drug virtual screening system for crystal complexes, including a visualization subsystem, an evaluation toolbox system, an AI model management subsystem, a large-scale sampling subsystem, a virtual screening subsystem and a data log storage subsystem; Starting from the known crystal complexes, through the visualization subsystem, the evaluation toolbox system, the AI ​​model management subsystem, the large-scale sampling subsystem, and the virtual screening system, a batch of candidate compounds that meet the requirements are recommended. Based on this system, the generation of compound libraries is organically combined with subsequent virtual screening. Users can generate a batch of expected compounds as long as they describe the mode of action of the drug on the protein and the requirements that the drug needs to have. The automated system reduces user intervention and increases the efficiency of R&D.

The invention belongs to the field of medical embolization devices, relates to a sodium alginate microsphere targeted vascular embolization agent containing an antineoplastic drug and a preparation method thereof. Alginic acid is taken as a pharmaceutical carrier, the antineoplastic drug etoposide is a pharmaceutical active ingredient, divalent metal cation or calcium ion solution is taken as a solidifying agent, and the sodium alginate encapsulates the etoposide to prepare ideal particle size-controllable sodium alginate microspheres comprising the etoposide, thus avoiding toxic side effect of traditional etoposide administration such as anaphylaxis and inconvenience. The vascular embolization agent changes the dosage form and route of administration way of the antineoplastic drug etoposide, has high efficacy and low toxicity, and is safely and effectively applied to clinical application. The vascular embolization agent has the advantages of mild preparation condition and simple and convenient operation, and is fit for large-scale production. The vascular embolization agent can be used for vascular embolization, local targeted tumor treatment, and treating small-cell carcinoma ofthe lung, oophoroma, carcinoma of testis, gastric cancer and liver cancer by administering the vascular embolization agent during operations.

The invention relates to a sodium alginate micro ball vessel suppository which contains soluble medicine, and relative preparation and application, wherein said agent can be divided into two kinds aswet ball and dry ball made from degradable biological material; said carrier comprises sodium alginate, blood serum albumin, chitose, or transparent sodium solution, via the static to be solidified with calcium ion, to be made into the micro ball at 20 mum-1000 mum. The inventive material has high mechanical strength, biological compatibility, biological degradability and stability. The inventioncan be used to cure the vessel suppository of variable cancers.