The invention discloses a contact thermal resistance testing system with variable pressure and-temperature in a profound hypothermia area. The contact thermal resistance testing system comprises a testing device, a pressure loading device, a heating and temperature measuring device and a refrigerating device; the testing device comprises a vacuum cavity, a thermal insulation multilayer material, an anti-radiation cold shield, a solid thermal insulation material, a sample clamp, a testing platform and a vacuum cavity bottom plate; the pressure loading device comprises a pressure sensor, an airinlet pipeline, a pressure-bearing corrugated pipe and a thermal insulation screw rod; the heating temperature measuring device comprises a heating plate, a temperature sensor and a heating wire; therefrigerating device comprises an oxygen-free copper cold head, a refrigerating machine and a compressor; and the pressure loading device, the heating and temperature measuring device and the oxygen-free copper cold head are mounted in the vacuum cavity, the pressure-bearing corrugated pipe is fixed to the oxygen-free copper cold head and the solid thermal insulation material through the thermal insulation screw rod, the refrigerating machine is mounted on the vacuum cavity bottom plate, and all the devices are tightly connected through screws. The contact thermal resistance testing system with the variable pressure and-temperature in the profound hypothermia area has the advantages of easy operation, small temperature fluctuation, high operability, short test time, high precision and thelike.