The invention discloses a strong-inhibition anticaving drilling fluid and application thereof. The strong-inhibition anticaving drilling fluid consists of 1000 parts of water, 20 to 60 parts of bentonite for drilling fluid, 5 to 20 parts of sodium carbonate, 5 to 20 parts of alkali, 10 to 20 parts of coating agent, 5 to 20 parts of flow pattern regulator, 5 to 20 parts of shale inhibitor, 10 to 30 parts of borehole stabilizer, 10 to 30 parts of plugging agent, 5 to 30 parts of lubricating agent, 5 to 40 parts of filtrate reducer, 1 to 10 parts of pH regulator, and a proper amount of salts and barite added according to the requirement. The strong-inhibition anticaving drilling fluid has the remarkable characteristics of properties of stabilizing a borehole, protecting an oil layer, improving the drilling speed, and preventing a balled bit and the like from approaching to oil-based drilling fluid.