The invention discloses a cone-beam X-
ray luminescence tomography system of combination imaging and a method thereof. The
system comprises a charge-coupled device (CCD) camera, an X-
ray source, an X-
ray detector, an electronic control rotating table and a narrow-band filter, wherein the
CCD camera, the X-ray source, the X-ray
detector, the electronic control rotating table and the narrow-band filter are coupled with a lens. The
CCD camera and the narrow-band filter are fixed in the same direction, and then a to-be-imaged object, the
CCD camera and the narrow-band filter are located on the same straight line; the X-ray source and the X-ray
detector are placed in the direction perpendicular to the CCD camera, and then the X-ray source, the to-be-imaged object and the X-ray detector are located on the same straight line; and the CCD camera, the electronic control rotating table, the X-ray source and the X-ray detector are controlled to operate by using a computer. According to the cone-beam X-ray
luminescence tomography system of the combination imaging and the method thereof, use ratios of X-rays are improved, and
medicine of the to-be-imaged object can be fully excited; X-
ray irradiation time is shortened, X-
ray irradiation doses are reduced, and popularization and application of X-ray excitation imaging are benefited;
information fusion of two types of imaging modals is achieved, and more biological characteristics of the to-be-imaged object are acquired.