Provided are a thin film transistor array substrate, a manufacturing method and a liquid crystal display panel. The thin film transistor array substrate comprises a substrate, a first metal layer, a first insulation layer, an active layer, a second metal layer, a second insulation layer, a third metal layer, a third insulation layer and a pixel electrode. The first metal layer is formed on the substrate and comprises a scanning line and a grid. The first metal layer is covered with the first insulation layer, and the active layer is formed on the first insulation layer. The second metal layer is formed on the first insulation layer and comprises a source electrode and a drain electrode. The second metal layer is covered with the second insulation layer, and a first contact hole and a second contact hole are formed in the second insulation layer. The third metal layer is formed on the second insulation layer and comprises a data line and a conductive block, the data line is connected with the source electrode through the first contact hole, and the conductive block is connected with the drain electrode through the second contact hole. The third metal layer is covered with the third insulation layer, and a third contact hole is formed in the third insulation layer. The pixel electrode is formed on the third insulation layer, and the pixel electrode is connected with the conductive block through the third contact hole.