The invention discloses a large, thick, high-strength and high-toughness TMCP type steel plate and a production method thereof. The large, thick, high-strength and high-toughness TMCP type steel plate is composed of, by weight, 0.06%-0.08% of C, 0.20%-0.40% of Si, 1.40%-1.50% of Mn, 0.015% or less of P, 0.005% or less of S, 0.020-0.030% of Nb, 0.030%-0.050% of Alt, the balance Fe and inevitable impurities and 0.20% or less of Pcm. According to the steel plate, the components are simple, only a proper amount of microalloy Nb is added, and the precious elements such as V, Ti and Ni are not added; production cost is low, and the probability of large-scale production is increased. The steel plate is of a mixed structure mainly containing bainite, ferrite, pearlite and martensite and has a good comprehensive mechanical property; the steel plate is better in matching of the components and the strength and toughness, and it is guaranteed that the steel plate has the excellent comprehensive mechanical property; particularly, the impact performance of half of the plate in the thickness direction is good at the low temperature of minus 40 DEG C, and the method can be widely used for producing low-temperature-resistant building steel and engineering steel used in extremely cold climate. The method has the advantages that the production cost is low, and the technique is simple; the performance of products is excellent, and the comprehensive mechanical property of the products is stable.