The invention relates to mulberry fruit health care nutritious liquor and a preparation method thereof, belonging to the liquor manufacturing technical field. Raw materials such as mulberry, fructus rosae, sea backthern, honeysuckle, citric acid, honey, probiotics, white sugar and water and the like are washed, dried, sterilized, smashed, pulp, fermented to prepare a first wine liquid and a second wine liquid; the first wine liquid and the second wine liquid are blended according to the proportion of 15:70, added with honeysuckle juice, and then filtered; after the filtering medium is fermented for 15 days, the liquor is prepared. In the manufacture of the liquor, a harmful additive is not added, thus solving the problem that in the existing technique, the mouthfeel and the natural flavor of the mulberry fruit wine are influenced owing to the addition of the harmful additive to cause the nutritional value and medicinal value not to be fully utilized, and the real health care efficacy of the mulberry fruit wine can not be achieved. The liquor is characterized by pure mouthfeel and long aftertaste, has the efficacies of hyperglycemic, improving eyesight, calming the nerves, nourishing yin and supplementing blood, hair blacking and beauty treatment, easing fatigue and the like, is suitable for being drunk by various crowds.