The invention discloses a mold opening mechanism with a mechanical advantage. The mold opening mechanism comprises a base, a still mold installing plate, a moving mold installing plate and a transmission mechanism, wherein the still mold installing plate is arranged on the base, the moving mold installing plate is matched with the sill mold installing plate, and the transmission mechanism is used for driving the moving mold installing plate to move front and back so as to achieve the action of mold opening / closing. The transmission comprises a bolt, a nut, a connecting rod and a hand wheel, wherein the bolt is sleeved with the nut, the hand wheel is installed on the end portion of the bolt, and the connecting rod is movably hinged between the moving mold installing plate and the nut. Compared with the prior art, according to the mold opening mechanism with the mechanical advantage, the phenomena that mold shifting and mold damaging are prone to occurring when a mold is opened and closed manually are overcome. The mold opening mechanism is simple in structure, low in manufacturing cost and wide in application range; by means of threaded transmission, operating of the mechanism is precise and reliable, the mold closing force is large, and mole swelling and leak out are avoided; operation is convenient, the process of mold opening and closing can be achieved just by shaking the hand wheel manually, the labor intensity is reduced, and the service life of the mold is prolonged; the operation time of mold opening and closing is short, and the production efficiency of products is improved.