The invention discloses a compound medicine for treating anaphylactic rhinitis-asthma syndrome and a preparation method and application thereof. The compound medicine comprises, by weight, of 60-300 parts of astragalus mongholicus, 20-100 parts of ephedra, 20-200 parts of divaricate saposhnikovia root, 20-200 parts of trichosanthes peel, 20-200 parts of allium macrostemon, 20-200 parts of rhizoma pinellinae praeparata, 12-120 parts of rhizoma zingiberis, 20-200 parts of almond, 20-200 parts of bighead atractylodes rhizome, 20-200 parts of cassia twig, 20-200 parts of poria cocos, 30-300 parts of radix paeoniae alba, 30-300 parts of lumbricus and 30-300 parts of honey-fried licorice root. The compound medicine for treating the anaphylactic rhinitis-asthma syndrome has the advantages of being good in curative effect, short in course of treatment, thorough in curative effect, free of side effect and the like. The preparation method for preparing the compound medicine for treating the anaphylactic rhinitis-asthma syndrome is simple, rapid, high in efficiency and easy to operate. Prepared mixture, troche, capsules, pellets and the like are convenient to carry and take.