142results about How to "Low acute toxicity" patented technology

The invention discloses a disposable controlled completely-degradable plastic packing bag, which is formed through melting, blending, extruding and film-blowing of components comprising in parts by weight: 20 to 45 parts of polyvinyl alcohol, 72 to 87 parts of starch, 10 to 20 parts of micromolecule plasticizer, 0.2 to 2 parts of modified inorganic nanometer additive, 0.1 to 1.5 parts of antioxidant, 0.5 to 3 parts of compatibilizer, 8 to 15 parts of inorganic filler, 0.1 to 1 part of ultraviolet absorber, and 0.1 to 1 part of pigment. The invention further discloses a preparation method of the plastic packing bag. The nanometer composite modifier in the packing bag adopts a micromolecule plasticizer easy to form a hydrogen bond with the starch, a certain amount of inorganic nanometer additives subject to surface treatment are added in the packing bag, so that after PVA (polyvinyl acetate) is modified by the nanometer composite modifier, the use amount of the molecule plasticizers is reduced greatly, the cost is lowed, the reduction of the mechanical property of a film is avoided, and the controlled completely-degradable film with excellent mechanical property and the use performance can be obtained.

The present invention discloses water suspended nano pesticide capsule preparation prepared via emulsion polymerization process. It has capsule shell of styrene, isocyanate, acrylate and methacrylate copolymer, and core comprising ididacloprid, high effect cypermethrin or diflubenzuron as effective component; contains pesticide 0.2-5 wt%, capsule shell 5-30 wt%, additive 10-35 wt% and water in proper proportion. The nano capsule is disersive spherical particle of size smaller than 100 nm. Compared with traditional pesticide preparation forms, the present invention has the features of water based solvent, nano level dispersive effective component, high stability, etc. and may be used in killing various pests of fruit tree, vegetable, flower, cotton, tobacco, etc.

The invention relates to multifunctional compound microecological preparation nano-selenium-recombination expression VIP (vasoactive intestinal peptide)-lactococcus lactis and a preparation method. Toxic sodium selenite can be converted into non-toxic red simple-substance nano-selenium, and synthesized nano-selenium is enriched in lactococcus lactis NZ9000 in cells. The invention also discloses amethod for preparing a multifunctional compound microecological preparation SENPs-rVIP-L.lactis NZ9000 based on lactococcus lactis NZ9000. The problems that existing selenium supplementing additives have high toxicity action and low bioavailability and easily cause environment pollution, existing production technical procedures are complicated, the cycle is long and the production cost is high andthe problems about remaining of antibiotics, drug resistance and the like are solved.

The invention provides o-anilino benzoic acid derivatives or pharmaceutically acceptable salts thereof as well as a preparation method and applications thereof in preparing medicines or functional food for preventing and/or treating tumors and other abnormal proliferation diseases of organisms and in preparing medicines or functional food for preventing and/or treating inflammations, pains and other diseases of organisms.

The present invention discloses a new type medicine target slowly-releasing carrier material and its preparation process. Said medicine target slowly-releasing carrier material is made up by utilizing attapulgite and Fe3O4. Its principle lies in that it utilizes the large specific surface area and adsorbability of ultrafine high-purity attapulgite and uses it as carrier material of medicine to prolong action time of medicine in interior of human body, raise concentration of local medicine, raise therapeutic effect of medicine and reduce toxic side effect of the medicine, and utilizes magnetization treatment so as to attain the goal of making target administration and controlling release of medicine.

The invention discloses an insecticide microcapsule suspension type liquid medicine fertilizer and a preparation method and application thereof.The insecticide microcapsule suspension type liquid medicine fertilizer is prepared from insecticide, an organic solvent, a cyst wall material, a pH adjusting agent I for preparing microcapsules, a nitrogen fertilizer, a phosphate fertilizer, a potash fertilizer, a micronutrient fertilizer, an emulsifying agent, a filler, a dispersing agent, a defoaming agent, a thickening agent, an antifreezing agent and water, wherein the pH adjusting agent I is acid.The raw materials further include a pH adjusting agent II for adjusting the pH value of the liquid medicine fertilizer, wherein the pH adjusting agent II is alkali.The average control effect of the insecticide microcapsule suspension type liquid medicine fertilizer on wheat aphid is 80.0% or above, meanwhile, the yield of eggplants can be increased, and the N, P and K unit nutrient partial productivity is improved.The insecticide microcapsule suspension type liquid medicine fertilizer is simple and reasonable in technology, reduces the material grinding size as much as possible, is low in energy consumption, suitable for industrial production and suitable for being adopted in a small area, and saves material resources, financial resources and labor force.

The present invention relates to water suspended nano Ivermectin capsule preparation prepared via emulsion polymerization process. It has capsule shell of styrene, isocyanate, acrylate and methacrylate copolymer, and core comprising biologically originated pesticide and animal remedy Ivermectin as effective component; contains Ivermectin 0.2-2 wt%, capsule shell 5-30 wt%, additive 10-35 wt% and water in proper proportion. The nano capsule is disersive spherical particle of size smaller than 100 nm. Compared with traditional pesticide preparation forms, the present invention has the features of water based solvent, nano level dispersive effective component, high stability, etc. and may be used in killing animalí»s parasite and various pests of fruit tree, vegetable, flower, cotton, tobacco, etc.

The invention relates to a process for preparing avermectin and derivant dimethylamino avermectin, ivermectin, and doramectin slow release nanometer micro-balloon preparation. The technical procedures comprise suspending the suspending solution of 1%-40% unequal avermectin-type medicine, 0%-4% divinylbenzene (cross linking agent), (metyl group) methyl acrylate of 1% BPO (initiating agent) or solvent of methacrylic acid glycidyl ester in an aqueous phase of 40 DEG C with 1% sodium dodecyl benzene sulfonate and 0.5% gelatine or 0.5% PVA (the size ratio of an oil phase and the aqueous phase is 1:3) in a three-mouth bottle with an agitator, a reflux condensing tube and a thermometer, adding numerous ml of 0.5% methylene blue, regulating ultrasonic homogenization power, heating-up to 61 DEG C at 5 DEG C/10mins after the grain size is even, aggregating for two hours, heating-up to 85 DEG C with the same speed, aggregating for 8 hours and preparing 50nm-100nm avermectin-type medicinal nanometer micro-balloon preparation with different medicine-loading amount, and the packaging and loading rate reaches more than 91%. The invention solves the problem of long-acting controlled release of biological medicament, reduces the toxic and side effect simultaneously, improves the biological availability, reduces the cost and is friendly to the environment.

The invention discloses a lipid microsphere injection containing sodium demethyl cantharidate-phosphatide complex and preparation method thereof. The injection comprises the sodium demethyl cantharidate-phosphatide complex, fat-soluble medium, surfactant and other ingredients. In the sodium demethyl cantharidate-phosphatide complex, the molar ratio of sodium demethyl cantharidate to phosphatide is 1-1:10. The prepared sodium demethyl cantharidate-phosphatide complex improves the distribution of sodium demethyl cantharidate in oil-water 2-phase interfacial film and oil phase greatly, increasesthe entrapment efficiency of the medicine in preparation, realizes the interfacial film loading medicine, reduces the toxicity, and can carry out targeting drug release in vivo. The prepared lipid microsphere injection reduces the vascular stimulation of sodium demethyl cantharidate, improves the curative effect, and reduces toxic and side effect.

The invention relates to the field of pesticide preparations, and in particular relates to a prochloraz microcapsule suspending agent and a compound preparation thereof. The prochloraz microcapsule suspending agent is prepared from prochloraz, a solvent, an emulsifier, a wet dispersing agent, a capsule wall material, an initiator and water. According to the prochloraz microcapsule suspending agent, the technical problem that prochloraz is not suitable for being made into a suspending agent is solved; meanwhile, the microcapsule suspending-suspending seed coating agent provided by the invention can be used for effectively preventing and treating pests and diseases such as rice bakanae disease, rice black-streaked dwarf disease, thrips and rice fulgorid, and has an extremely good slow release effect.

The present invention discloses a piperazine (piperidine) cyclohexyl derivative and applications of the piperazine (piperidine) cyclohexyl derivative in treatment of neuropsychiatric diseases. According to the present invention, the pharmacological experiment results show that the piperazine (piperidine) cyclohexyl derivative provides high affinity with a dopamine D2 receptor, a dopamine D3 receptor, a serotonin 5-HT1A receptor and a serotonin 5-HT2A receptor, provides good D3/D2 receptor selectivity and good 5-HT1A/5-HT2A receptor selectivity, and provides low affinity with alpha receptor; the in vivo test results show that the preferred compound has characteristics of good anti-schizophrenia effect, good pharmacokinetic property, low side effect, low acute toxicity and high safety, and has the development value of being adopted as the novel efficient and low-toxic anti-neuropsychiatric disease; and the piperazine (piperidine) cyclohexyl derivative is a compound represented by the structural general formula (I), or a geometric isomer, an optical isomer, a salt, a hydrate or a solvate thereof. The formula (I) is defined in the specification.

The invention relates to a sterilization compound containing benzothiostrobin and difenoconazole. The sterilization compound comprises active ingredients and pesticide preparation auxiliary components, wherein the active ingredients comprise benzothiostrobin and difenoconazole. The benzothiostrobin and the difenoconazole in the sterilization compound provided by the invention belong to two bactericides with different mechanisms, and can be compounded within a certain proportion range to generate a remarkable synergistic role. The sterilization compound is remarkable in prevention and control effect, is safe to crops without damage risk, is reduced in acute toxicity to mammals, and is improved in safety.

The invention relates to niclosamide ethanolamine salt nano suspending agent for killing oncomelania and its preparation method, belongs to oncomelania-killing drug and insoluble drug nano preparation technology field. The method comprises steps of adding dimethyl sulphoxide to stablizer 1%-10% in mass content and niclosamide ethanolamine salt 5%-25% in mass content and mixing ,confecting solution, obtaining niclosamide ethanolamine salt nano suspending agent stock solution, adding it to aqueous solution when stirring niclosamide ethanolamine salt content being 0.01%-1%, niclosamide ethanolamine salt grain size being 50nm-1 mum, obtaining niclosamide ethanolamine salt nano suspending agent. The inventive method can make water-insoluble niclosamide ethanolamine salt disperse well in waterbody. The solution can be used while being prepared. The inventive niclosamide ethanolamine salt nano suspending agent is simply prepared, and promote bioavailability while meet the need of killing snail and reduce the toxicity to fish.

The invention discloses a composition for pest control and its preparation method. The composition can solve the problems that pests cannot be rapidly killed by the prior art and main quarantine pestscan generally resist hydrogen phosphide and is poor in pest killing effect. The composition is prepared from, by volume, 10-60 parts of gaseous ethyl formate and 40-90 parts of inert gas. The invention further provides an application of the composition in preparing pesticide for pest control. The composition can rapidly kill pest and is environment-friendly. The preparation method is simple and convenient to operate, and suitable for popularization and application.

The invention relates to a melamino-formaldehyde resin encapsulated acetamiprid microcapsule, and a preparation method thereof. The microcapsule is technically characterized by comprising the following components: melamine, a formaldehyde solution, acetamiprid, chloroform, an emulsifying agent, a dispersing agent, water, an acid catalyst and a base catalyst. The preparation method comprises the following steps of: putting melamine and the formaldehyde solution in a three-neck flask, adding the base catalyst and regulating, and heating to obtain a melamino-formaldehyde prepolymer; putting the acetamiprid, chloroform, the emulsifying agent, and water in a reaction flask, and stirring to obtain a pre-emulsification solution; mixing the pre-emulsification solution and the prepolymer, adding acid and catalyzing, and adding an appropriate amount of dispersing agent, raising temperature to 60 DEG C, reacting for three hours and stopping reaction; and washing a product by using water for multiple times, and suction-filtering and drying to obtain a microcapsule product. The encapsulation rate of the microcapsule is relatively high, sustained release time is long, pollution to environment is reduced, the preparation method is simple, wall materials are low in cost and the microcapsule is suitable for large-scale production and application.

The invention discloses a surface active agent containing selenous anions and a preparation method and application thereof, and belongs to the technical field of the daily chemical industry. The surface active agent is benzyl selenium-alkyl sulphate, the structural formula is C6H5CH2Se(CH2)nSe(CH2)nSO4-M+, wherein n in the formula is an integer from 2 to 4, and M+ is one of a sodion or a potassiumion or an ammonium ion. The surface active agent containing selenous anions is mild in synthesis condition, no special equipment requirement is needed, the energy consumption is low, and raw materials are easy to obtain; the liquid interface activity of the surface active agent containing selenous anions is better than the gas-liquid surface activity, the excellent dynamic foaming performance isachieved, the surface active agent containing selenous anions has the better oxidation resistance and free radical removal capability compared with a surface active agent containing single selenium atoms, and the cytotoxicity, the aquatic organism acute toxicity and the skin irritation are low.

The invention relates to a layer feed containing NANO-Se. The selenium-rich layer feed is prepared by breaking and smashing 60 parts of corn and 23 parts of soybean meal into 40-mesh particles, adding 4.6 parts of wheat bran, 12 parts of mixtures and 0.4 parts of NANO-Se, and mixing in a mixer for 20min. The NANO-Se (red elemental selenium) is high in bioavailability and very low in acute toxicity. As the use amount of NANO-Se (red elemental selenium) is small and no toxicity is caused to hens, the egg yield is not affected, the nutritional level of amino acid in the hens is raised, and the egg production is facilitated.