Ivermectin water suspension nano capsule prepn and its preparing method

Abstract

The present invention relates to water suspended nano Ivermectin capsule preparation prepared via emulsion polymerization process. It has capsule shell of styrene, isocyanate, acrylate and methacrylate copolymer, and core comprising biologically originated pesticide and animal remedy Ivermectin as effective component; contains Ivermectin 0.2-2 wt%, capsule shell 5-30 wt%, additive 10-35 wt% and water in proper proportion. The nano capsule is disersive spherical particle of size smaller than 100 nm. Compared with traditional pesticide preparation forms, the present invention has the features of water based solvent, nano level dispersive effective component, high stability, etc. and may be used in killing animalí»s parasite and various pests of fruit tree, vegetable, flower, cotton, tobacco, etc.

Description

technical field [0001] The invention relates to a water-suspended nanocapsule of ivermectin, which belongs to the formulation technology of biological source pesticides and veterinary drugs. Background technique [0002] Ivermectin is the reduction product of avermectin after chemical hydrogenation. It is an antibiotic drug with repellent activity against nematodes, insects and mites, and is used for the treatment of gastrointestinal nematodes, cowhide maggots, skin maggots, sheep nose maggots, sheep itch mite and pig mange mite in livestock sick. It has high efficiency, broad spectrum, safety, long duration of drug effect, stable drug effect, does not kill natural enemies, and is conducive to maintaining ecological balance. It is widely used in cotton, field crops, fruit trees, tea, vegetables, medicinal plants and garden flowers and plants, etc. . It has lower residue than Abamectin and is safer to use. The main dosage form of ivermectin disclosed in the prior art is e...

AI Technical Summary

Problems solved by technology

[0003] 1. Contains a large amount of organic solvents, such as toluene, xylene, etc., causing thousands of tons of organic solvents to be discharged into nature every year, wasting resources and seriously polluting the environment

[0004] 2. When used, it needs to be diluted with water to form an emulsion. The active ingredients are micron-scale dispersed. The dispersibility of the active ingredients is poor and the effective utilization rate is low, resulting in a large amount of pesticides, resulting in increased agricultural costs and a large number of pesticide residues, which seriously affects the quality of agricultural products.

[0005] 3. The active ingredients have poor permeability, and the active ingredients remaining on the leaves are decomposed and wasted due to environmental factors such as light and air.

[0006] 4. The colonization of biological pesticides in the soil is poor, and the special ecological environment of the soil often inhibits the efficacy of biological pesticides, which limits the large-scale promotion of biological pesticides

[0007] Compared with EC, the microemulsion of ivermectin can better solve the problem of water-based and high dispersion, but it is not a long-acting dosage form, and the release cannot be controlled. More importantly, the cost is high and the effect is not ideal