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Drug targeting slow-release carrier material and preparing process thereof

A slow-release carrier and drug technology, which can be used in pharmaceutical formulations, inactive medical preparations, inorganic inactive ingredients, etc., can solve the problems of toxic and side effects affecting human health, poor biocompatibility, poor stability, etc. The effect of purification and enrichment, stable performance and cost saving

Inactive Publication Date: 2004-09-15
甘肃省中心实验室
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor biocompatibility and stability of organic materials, they can be biodegraded, the decomposition products are in various forms, the process is complicated, and the toxic and side effects will affect human health, which limits its application to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031](1) Nano-superparamagnetic Fe 3 o 4 The synthesis of: under normal temperature conditions, the concentration is 1.0Mol of 100mLFeCl 3 solution and 100mL FeCl 2 Add the solution into a mixing bucket with a stirring speed of 300-500 rpm at a ratio of 1:1, 3 Add polyacrylic acid 4mL, add protective agent polyacrylic acid, stir for 10 minutes to make it fully mixed, drop (1+1) ammonia water into the mixed solution at a rate of 2.0mL / min, until the pH value of the mixed solution reaches 10 , stop adding ammonia water, continue to stir evenly for 10 minutes, and then put the synthesized magnetic liquid into an ultrasonic cleaning machine with a temperature of 50 ° C for 30 minutes to ultrasonically disperse, that is, to obtain a brown-black particle with a particle size of 5-50 nm and an average particle size of 20 nm. nano-superparamagnetic Fe 3 o 4 Suspension 11.6g;

[0032] (2) Purification of attapulgite ore: crush attapulgite raw ore, coarsely grind to -60 mesh, 3 ...

Embodiment 2

[0036] (1) Nano-superparamagnetic Fe 3 o 4 The synthesis of: under normal temperature conditions, the concentration is 1.0Mol of 100mLFeCl 3 solution and 120mL FeCl 2 Add the solution into a mixing bucket with a stirring speed of 300-500 rpm at a ratio of 1:1, 3 Add polyacrylic acid 4mL, add protective agent polyacrylic acid, stir for 10 minutes to make it fully mixed, drop (1+1) ammonia water into the mixed solution at a rate of 2.0mL / min, until the pH value of the mixed solution reaches 10 , stop adding ammonia water, continue to stir evenly for 10 minutes, and then put the synthesized magnetic liquid into an ultrasonic cleaning machine with a temperature of 50 ° C for 30 minutes to ultrasonically disperse, that is, to obtain a brown-black particle with a particle size of 5-50 nm and an average particle size of 20 nm. nano-superparamagnetic Fe 3 o 4 Suspension of 12.7g;

[0037] (2) Purification of attapulgite ore: crush attapulgite raw ore, coarsely grind to -60 mesh,...

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PUM

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Abstract

The present invention discloses a new type medicine target slowly-releasing carrier material and its preparation process. Said medicine target slowly-releasing carrier material is made up by utilizing attapulgite and Fe3O4. Its principle lies in that it utilizes the large specific surface area and adsorbability of ultrafine high-purity attapulgite and uses it as carrier material of medicine to prolong action time of medicine in interior of human body, raise concentration of local medicine, raise therapeutic effect of medicine and reduce toxic side effect of the medicine, and utilizes magnetization treatment so as to attain the goal of making target administration and controlling release of medicine.

Description

technical field [0001] The invention relates to a novel drug targeting sustained release carrier material and a preparation process thereof. Background technique [0002] With the development of medical science and clinical technology, especially the breakthrough and clinical application of targeted therapy technology, the requirements for the performance of drug carrier materials are also getting higher and higher. Drug carrier materials have developed from single excipients or fillers to complex and multifunctional directions. The preparation technology of drug carrier materials with targeting functions and controlled release capabilities is an important development direction. In addition, it has potential application prospects in research fields such as cell separation, immobilized enzymes, and targeted drug delivery, and has attracted much attention. Especially in the past 10 years, magnetic carriers have attracted extensive attention from scholars at home and abroad as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K47/46
Inventor 汤庆国
Owner 甘肃省中心实验室
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